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United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
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Comparison Of Sheep, Goats, And Calves As Infection Models For Mycobacterium Avium Subsp. Paratuberculosis, Judith R. Stabel, J. P. Bannantine, Jesse M. Hostetter
Comparison Of Sheep, Goats, And Calves As Infection Models For Mycobacterium Avium Subsp. Paratuberculosis, Judith R. Stabel, J. P. Bannantine, Jesse M. Hostetter
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
Animal infection models to study Mycobacterium avium subsp. paratuberculosis (MAP) infection are useful for evaluating the efficacy of vaccines and other therapeutics for the prevention or treatment of infection. The goal of the present study was to compare smaller ruminants, sheep and goats, with calves as infection models. Neonatal sheep, goats, and calves (n = 4) received 109 cfu of a cattle isolate of MAP in milk replacer on days 0, 3 and 6 in a 12-month study and sampled monthly thereafter. Results demonstrated a robust antigen-specific IFN-γ response at 90 days post-inoculation for sheep and goats, with lower responses …