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Full-Text Articles in Life Sciences
Development Of Amino Acid Salt-Based Curcumin@Lysine Acetate Co-Amorphous System Using Liquid-Assisted Grinding For Improved Solubility And Dissolution, Udaykumar Patil, Snehal Rawal, Jidnyasa Pantwalawalkar, Sopan Nangare, Dilip Dagade, Pravin Patil, Namdeo R. Jadhav
Development Of Amino Acid Salt-Based Curcumin@Lysine Acetate Co-Amorphous System Using Liquid-Assisted Grinding For Improved Solubility And Dissolution, Udaykumar Patil, Snehal Rawal, Jidnyasa Pantwalawalkar, Sopan Nangare, Dilip Dagade, Pravin Patil, Namdeo R. Jadhav
The Thai Journal of Pharmaceutical Sciences
Curcumin, multivalued phytoceutical, exhibits appreciable safety. However, its therapeutic utility is significantly compromised due to low aqueous solubility, and thus, poor absorption and low bioavailability become apparent. To surpass this limitation, the present work aims to develop amino acid salt-based curcumin@lysine acetate co-amorphous system for improved solubility and dissolution. Initially, screening of curcumin-amino acid mixtures was performed for saturation solubility assessment. Considering the outcome, lysine acetate was formulated to generate a co-amorphous mixture (COAM) by liquid-assisted grinding and evaluated for saturation solubility and different spectroscopical characterizations. Curcumin-lysine acetate COAM tablet formulation was developed by direct compression method and evaluated for …
Preparation And Characterization Of Curcumin-Loaded Liposomes For Delivery To The Lungs, Safura Binti Mohd Mohari, Kevin M. G. Taylor, Nattika Nimmano
Preparation And Characterization Of Curcumin-Loaded Liposomes For Delivery To The Lungs, Safura Binti Mohd Mohari, Kevin M. G. Taylor, Nattika Nimmano
The Thai Journal of Pharmaceutical Sciences
Curcumin-loaded liposomes comprising dipalmitoylphosphatidylcholine, cholesterol, and dioleoylphosphatidylethanolamine (72:8:20 mole ratio) were prepared by the thin-film hydration method, followed by probe sonication to achieve a mean diameter (FSI) pre-cooled at 2–8°C for at least 90 min at 15 L/min. Curcumin recovered from the impactor and nebulizer was quantified using a validated high-performance liquid chromatography method. Overall, 2.5% w/w curcumin-loaded liposomes was the optimal formulation based on the maximum encapsulation efficiency of approximately 87% and mean hydrodynamic diameter of 97 nm. This chosen curcumin concentration was effectively aerosolized with a fine particle fraction of 53.25%, and a fine particle dose of 53 …
The Study Of Physical Properties And Formulation Of Self-Assembling Nanogel From Grafted Hydrophilic Polymer Backbone As Stabilization System For Curcumin, Penpimon Charoenkanburkang, Tisana Kaewruethai, Pornchai Rojsitthisak, Jittima Amie Luckanagul
The Study Of Physical Properties And Formulation Of Self-Assembling Nanogel From Grafted Hydrophilic Polymer Backbone As Stabilization System For Curcumin, Penpimon Charoenkanburkang, Tisana Kaewruethai, Pornchai Rojsitthisak, Jittima Amie Luckanagul
The Thai Journal of Pharmaceutical Sciences
Introduction: The aim of this work is to formulate and study the thermoresponsive system with hyaluronic acid (HA) as a polysaccharide backbone grafted with poly-(N-isopropylacrylamide) (pNIPAM) for stabilization of highly sensitive molecule. Methods: The nanogel forming polymer was synthesized through EDC/NHS coupling reaction. The HA grafted pNIPAM (HA-g-pNIPAM) can be self-assembled to form gel particle. The synthesized HA-g-pNIPAM polymers were characterized by 1H NMR. Size, influence of media to forming nanogel, thermoresponsive behavior and influence of HA-g-pNIPAM nanogel network on curcumin loading capacity and stability were investigated by dynamic light scattering (DLS) and UV-VIS spectrophotometry. Result and Discussion: The results …
Variation Of Total Curcuminoids And Volatile Oil Content In Turmeric Rhizome In Indonesia, Weravut Pothitirat, Sundari Desi, Phatsawee Jansook, Kingkan Sanpanya, Wandee Gritsanapan
Variation Of Total Curcuminoids And Volatile Oil Content In Turmeric Rhizome In Indonesia, Weravut Pothitirat, Sundari Desi, Phatsawee Jansook, Kingkan Sanpanya, Wandee Gritsanapan
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
In Vitro Inhibitory Effect Of Turmeric Extract From Curcuma Longa On Shrimp Pathogenic Vibrios(ผลของสารสกัดขมิ้นชันต่อการยับยั้งการเจริญของเชื้อวิบร..., Pomchai Rojsitthisak, Yanin Limpanon, Nutchanart Thipmongkolsilp, Bang-On Kongtong, Janenuj Wongtavatchai
In Vitro Inhibitory Effect Of Turmeric Extract From Curcuma Longa On Shrimp Pathogenic Vibrios(ผลของสารสกัดขมิ้นชันต่อการยับยั้งการเจริญของเชื้อวิบร..., Pomchai Rojsitthisak, Yanin Limpanon, Nutchanart Thipmongkolsilp, Bang-On Kongtong, Janenuj Wongtavatchai
The Thai Journal of Pharmaceutical Sciences
The commercially available turmeric extract from Curcuma longa L. was standardized and evaluated for antibacterial activity against shrimp pathogenic vibrios. High-performance liquid chromatographic determination of the extract revealed 99.42% of the tot...
Simultaneous Determination Of Individual Curcuminoids In Turmeric By Tlc-Densitometric Method(การวิเคราะห์หาปริมาณเคอร์คูมินอยด์แต่ละชนิด ในเหง้าขมิ..., Supinya Tewtrakul, Wanchai De-Eknamkul, Nijsiri Ruangrungsi
Simultaneous Determination Of Individual Curcuminoids In Turmeric By Tlc-Densitometric Method(การวิเคราะห์หาปริมาณเคอร์คูมินอยด์แต่ละชนิด ในเหง้าขมิ..., Supinya Tewtrakul, Wanchai De-Eknamkul, Nijsiri Ruangrungsi
The Thai Journal of Pharmaceutical Sciences
A simple, rapid and accurate method of TLC-densitometry was developed to quantitate simultaneously the three curcuminoid components in the dried turmeric rhizome of Curcuma longa L. (Zingiberaceae). Practically, the curcuminoids in powdered turmeric were...