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In Vivo And In Silico Anti-Arthritic Studies Of Chlorogenic Acid From The Rhizome Of Lasia Spinosa (L.) Thwaites (Araceae), M. Arya Lakshmi, D. S.N.B.K Prasanth, K. Gana Manjusha, B. Ganga Rao
In Vivo And In Silico Anti-Arthritic Studies Of Chlorogenic Acid From The Rhizome Of Lasia Spinosa (L.) Thwaites (Araceae), M. Arya Lakshmi, D. S.N.B.K Prasanth, K. Gana Manjusha, B. Ganga Rao
The Thai Journal of Pharmaceutical Sciences
Aim: The aim of the study was to examine the anti-arthritic function of methanol extract of Lasia spinosa (MELS) and chlorogenic acid (CA) in the rats of Freund’s complete adjuvant (FCA) mediated arthritis by in vivo and In silico studies. Materials and Methods: The MELS was subjected to acute oral toxicity in rats and tested against FCA induced arthritis in rats. Large-scale isolation and chromatographical analysis with spectral review verified that CA is responsible for the pharmacological effects reported. The efficacy of MELS and CA against CFA-induced arthritis was subsequently tested for hematological, biochemical, and in vivo anti-oxidant parameters in …
Inhibitory Effects Of Manosa Alliacea In Freund’S Adjuvant Arthritis On Inflammatory Markers And Its Confirmation By In-Silico Strategy, D. S.N.B.K. Prasanth, Sk. Aminabee, A. Lakshmana Rao, Chakravarthi Guntupalli, Alavala Rajasekhar Reddy, Umasankar Kulandaivelu, S. N. Koteswara, P. Rajeshwari
Inhibitory Effects Of Manosa Alliacea In Freund’S Adjuvant Arthritis On Inflammatory Markers And Its Confirmation By In-Silico Strategy, D. S.N.B.K. Prasanth, Sk. Aminabee, A. Lakshmana Rao, Chakravarthi Guntupalli, Alavala Rajasekhar Reddy, Umasankar Kulandaivelu, S. N. Koteswara, P. Rajeshwari
The Thai Journal of Pharmaceutical Sciences
For the assessment of the curative effect of Manosa alliacea on Freud’s adjuvant (FA) arthritis on Swiss albino rats. Methanol extract from M. alliacea (MEMA) was administered orally at 200 mg/kg and 400 mg/kg, 28 days after FA immunization. For control and treatment groups, paw volume, body weight, hematological parameters, X-ray, and histological tests were measured. In addition, reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the levels of various inflammatory markers. In vitro, DPPH and H2O2 tests were used to evaluate the antioxidant capability. MEMA decreased paw volume and paw thickness, bodyweight considerably (P < 0.05, 0.01, 0.001), compared to hematological anomalies of arthritis control. X- rays tests and histological tests did not reveal significant structural changes in the rat ankle joints administered with MEMA. The levels of expression tumor necrosis factor - α, NF-Kβ, IL-1β, and COX-2 were significantly suppressed in the treatment groups. The in-silico study has shown that a number of chemical components in the plants under study can effectively bind to various inflammatory targets. That is why we say M. alliacea is a good source for treating rheumatoid arthritis.