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Full-Text Articles in Life Sciences
Regulation Of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors And Neurotransmitters, Susana Cohen-Cory
Regulation Of Cerebellar Purkinje Cell Development: Interactions Between Trophic Factors And Neurotransmitters, Susana Cohen-Cory
Student Theses and Dissertations
Previous study indicates that in the cerebellum. Nerve Growth Factor (NGF) and NGF receptors are highly expressed during late embryonic and early postnatal development, suggesting that NGF may play an important role in cerebellar ontogeny. However, while receptor had been localized to some cerebellar populations, delineation of receptor subtypes, and potential physiologic function remained to the defined. The objective of this thesis was to define the role that NGF plays in cerebellar ontogeny. Initial studies were devoted to the localization of NGF binding sites to cell types in the developing cerebellum, and to the definition of receptor subtypes. 125I-.NGF binding …
A Mutational Analysis Of The Period Locus Of Drosophila Melanogaster, Mary K. Baylies
A Mutational Analysis Of The Period Locus Of Drosophila Melanogaster, Mary K. Baylies
Student Theses and Dissertations
The period (per) gene of Drosophila melanogaster is fundamentally involved in the generation of biological rhythms. Three classes of per mutations which alter circadian periodicity have been identified: pers mutants have circadian behavioral rhythms of 19h instead of 24h; per mutants have long period rhythms of 28h; and per0 mutants have no detectable circadian rhythms. Steps have been taken to gather more information about per's role in the construction or maintenance of biological clocks. By analyzing transformed Drosophila lines, the amount of per product was found to be integral to the pace of the clock. Absence of. the …
Structure Of The Chicken Neuron-Glia Cell Adhesion Molecule, Ng-Cam: Origin Of The Polypeptides And Relation To The Ig Superfamily, Mark P. Burgoon
Structure Of The Chicken Neuron-Glia Cell Adhesion Molecule, Ng-Cam: Origin Of The Polypeptides And Relation To The Ig Superfamily, Mark P. Burgoon
Student Theses and Dissertations
The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of -200 kD, 135 kD, and 80 kD, which are detected at particular sites during development. Ng-CAM mediates a variety of functions that are known to be important in specific cell-cell interactions and the histogenesis of the nervous system, including neuron-neuron adhesion, neuron-glia adhesion, neurite fasciculation, and neuronal migration on glial cells. This thesis describes the characterization of cDNA that encode the entire Ng-CAM protein and the determination of the …
Structure And Function Analysis Of A Plant Transcription Activator, Fumiaki Katagiri
Structure And Function Analysis Of A Plant Transcription Activator, Fumiaki Katagiri
Student Theses and Dissertations
The cauliflower mosaic virus 35S promoter is composed of several cis-elements, each of which confers a different expression pattern in transgenic tobacco. One such cis-element, activation sequence (as)-1 (-83 to -63) mediates preferential expression in root. The element contains a tandem repeat of the motif TGACG, that is crucial for as-1 function and binding of a tobacco nuclear factor, activation sequence factor (ASF)-1. Two other TGACG-containing cis-elements from plant promoters were identified by a computer assisted search of a gene bank. These cis-elements, hex-1 from the wheat histone H3 promoter and nos-1 from the nopaline synthase promoter of T-DNA, also …