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Mutational And Expression Analysis Of Fbxw7 Gene In Colorectal Cancer Patients Among North Indian Population, Laraib Uroog
Mutational And Expression Analysis Of Fbxw7 Gene In Colorectal Cancer Patients Among North Indian Population, Laraib Uroog
Research Symposium
Background: Colorectal cancer is the third most common cancer worldwide with the incidence rate of 1.8 million (10.2%) (GOBOCON-2018). CRC is endemic to Kashmir Valley due to both, kangri use and non-veg food habit. The current study was designed to explore the possible correlation between that FBXW7 and colorectal cancer progression.
Methods: FBXW7 gene mutations and expression was analyzed in 173 colorectal carcinoma tissues along with the adjacent non-cancerous matched tissues using polymerase chain reaction-single stranded confirmation polymorphism assay. Gene expression analysis was conducted using qRT-PCR, western blot and IHC.
Results: In total, six mutations were found …