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The Effects Of 17alpha-Hydroxyprogesterone Caproate On The Development Of The Mesocortical Dopamine Pathway And Cognitive Behavior, Melanie Lolier
The Effects Of 17alpha-Hydroxyprogesterone Caproate On The Development Of The Mesocortical Dopamine Pathway And Cognitive Behavior, Melanie Lolier
Legacy Theses & Dissertations (2009 - 2024)
This dissertation examined the complex developmental impact of the clinically relevant synthetic progestin 17α-hydroxyprogesterone caproate (17-OHPC) on medial prefrontal cortex (mPFC) development. In rodents, the effects of 17-OHPC are subtle, but significant. In the Chapter II, we observed that 17-OHPC abolishes sex differences in dopaminergic fiber innervation and alters microglia phenotype in the prelimbic and infralimbic areas by the end of the first postnatal week. In the third chapter, the overall effect of 17-OHPC on the ontogeny of dopaminergic fiber innervation and synaptic bouton density were used to characterize the timing and duration of treatment effects in the mPFC. In …
The Role Of Progesterone Receptor In The Postnatal Development Of The Dentate Gyrus And Episodic-Like Memory, Andrew James Newell
The Role Of Progesterone Receptor In The Postnatal Development Of The Dentate Gyrus And Episodic-Like Memory, Andrew James Newell
Legacy Theses & Dissertations (2009 - 2024)
The hippocampus is a critical structure for the encoding and retrieval of declarative memories in humans, including episodic-memories. In rodents the steroid hormone receptor progesterone receptor (PR) is expressed in the dentate gyrus (DG) of the hippocampus during the postnatal period, a key stage in development of DG cytoarchitecture and connectivity. During the first postnatal week, the main cortical input to the hippocampal circuit, the perforant path, innervates the molecular layer (MOL) of the DG and forms temporary initial synaptic connections with pioneer neurons. By the third postnatal week, long-term synapses have been established with granule cells, the principle neurons …
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
Legacy Theses & Dissertations (2009 - 2024)
Numerous neurodevelopmental and neuropsychiatric diseases have a distinct sex bias in
The Role Of Progesterone Receptor In The Development Of The Mesocortical Serotonergic Pathway, Allyssa Phillips
The Role Of Progesterone Receptor In The Development Of The Mesocortical Serotonergic Pathway, Allyssa Phillips
Legacy Theses & Dissertations (2009 - 2024)
The mesocortical serotonergic pathway, consisting of serotonergic fibers projecting from the dorsal raphe nucleus (DRN) to the prefrontal cortex (PFC), regulates higher order executive functions and complex cognitive behaviors. Disruptions in this pathway lead to dysfunction in behavior and have been linked to several clinical disorders, including anxiety and ADHD. While this pathway continues to change throughout the lifespan, it is during early development that this pathway undergoes a rapid period of maturation, with the greatest rate of fiber innervation and synaptogenesis occurring in the mesocortical serotonergic pathway at this time. The development of a properly functioning circuit is directed …
The Role Of Progesterone Receptor In The Development Of The Mesocortical Dopaminergic Pathway, Jari Willing
The Role Of Progesterone Receptor In The Development Of The Mesocortical Dopaminergic Pathway, Jari Willing
Legacy Theses & Dissertations (2009 - 2024)
The mesocortical dopaminergic pathway, comprised of projections from the ventral tegmental area (VTA) to the prefrontal cortex (PFC), mediates many of the most complex forms of cognitive behaviors and has been associated with clinical disorders such as ADHD and schizophrenia. While this circuit continues to develop throughout much of the lifespan, there is a rapid period of maturation, early in development, in which this circuit is highly sensitive to disruption. Steroid hormone receptors are powerful transcription factors, capable of affecting a variety of neurodevelopmental processes and are expressed in many regions throughout the developing brain. Specifically, the nuclear progesterone receptor …