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Evidence Of A Role For G Protein Signaling Modulator 3 In Cell Division, Drew C. Wallace
Evidence Of A Role For G Protein Signaling Modulator 3 In Cell Division, Drew C. Wallace
Electronic Thesis and Dissertation Repository
Components of G protein-mediated signaling are associated with positioning and orienting the mitotic spindle in the process of cell division. However, a functional role for G protein signaling modulator 3 (GPSM3) in cell division has yet to be defined. The purpose of this study was to investigate a potential role for GPSM3 in cell division. Vascular smooth muscle cells (VSMCs) from Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats, that are known to express GPSM3, were used as a model system. Here I report that GPSM3 mRNA and protein levels varied during different stages of the cell cycle in SHR VSMCs. …
Characterization Of Numb As A Regulator Of Anaplastic Lymphoma Kinase, Ran Wei
Characterization Of Numb As A Regulator Of Anaplastic Lymphoma Kinase, Ran Wei
Electronic Thesis and Dissertation Repository
Cellular events rely on protein-protein interactions that are often mediated by modular domains which recognize particular sequence motifs in binding partners. The NUMB protein is the first described cell fate determinant and multifaceted adaptor that is involved in a wide variety of cellular events. NUMB mainly mediates protein interactions via its modular PTB domain. Here we present a systematic investigation of the NUMB-PTB interactome by employing an integrative strategy combining both protein and peptide arrays. We profiled NUMB-PTB binding specificity and interacting proteins genome-wide. The receptor tyrosine kinases (RTKs) are found highly enriched in the interactome, raising the possibility that …