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Assisted Reproductive Technologies Disrupt Genomic Imprinting In Human And Mitochondria In Mouse Embryos, Carlee R. White
Assisted Reproductive Technologies Disrupt Genomic Imprinting In Human And Mitochondria In Mouse Embryos, Carlee R. White
Electronic Thesis and Dissertation Repository
Infertile couples worldwide use assisted reproductive technologies (ARTs) to help conceive their own biological child. Due to the rising use of ARTs, there is continual emergence of new techniques implemented in human fertility clinics. When treatment is successful, there is an increased risk even within singletons for perinatal complications including preterm birth, intrauterine growth restriction, low and high birth weight and genomic imprinting disorders Beckwith Wiedemann Syndrome, Angelman Syndrome, and Silver-Russel Syndrome. Consequently, there is a need to investigate the effects of these treatments on the manipulated oocyte and preimplantation embryo. To address this, I first analyzed the combined effects …
Temperature-Dependent Alterations Of Brown Adipose Tissue Metabolism During Hibernation In The Thirteen-Lined Ground Squirrel, Ictidomys Tridecemlineatus., Sarah V. Mcfarlane
Temperature-Dependent Alterations Of Brown Adipose Tissue Metabolism During Hibernation In The Thirteen-Lined Ground Squirrel, Ictidomys Tridecemlineatus., Sarah V. Mcfarlane
Electronic Thesis and Dissertation Repository
Brown adipose tissue (BAT) is the major thermogenic tissue in small eutherian mammals. In hibernators, seasonal modifications of BAT are well documented but little is known about its functional regulation during hibernation. BAT metabolism is activated by sympathetic stimulation, so I hypothesized that further regulation at the mitochondrial level, as seen in other hibernator tissues, would be of little advantage. Contrary to my predictions, respiration rates of BAT mitochondria isolated from torpid thirteen-lined ground squirrels were suppressed by up to 62% compared with rates from individuals that aroused to interbout euthermia (IBE), when measured at 37°C. At 10°C, however, these …