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Investigation Of Molecular Mechanisms Underlying Tetracycline Resistance In Thermophilic Campylobacter Spp. Suggests That Previous Reports Of Tet(A)-Mediated Resistance In These Bacteria Are Premature, Caoimhe Lynch, Kayleigh Hawkins, Helen Lynch, John Egan, Declan Bolton, Aidan Coffey, Brigid Lucey
Investigation Of Molecular Mechanisms Underlying Tetracycline Resistance In Thermophilic Campylobacter Spp. Suggests That Previous Reports Of Tet(A)-Mediated Resistance In These Bacteria Are Premature, Caoimhe Lynch, Kayleigh Hawkins, Helen Lynch, John Egan, Declan Bolton, Aidan Coffey, Brigid Lucey
Department of Biological Sciences Publications
The true prevalence of tet(A), which codes for a tetracycline efflux pump, in thermophilic Camplyobacter spp. requires clarification after reports emerged in Iran (2014) and Kenya (2016) of the novel detection of tet(A) in Campylobacter. During our investigation of antibiotic resistance mechanisms in a sample of Irish thermophilic Campylobacter broiler isolates, it was determined that 100% of tetracycline-resistant isolates (n = 119) harboured tet(O). Accessory tetracycline-resistance mechanisms were considered as tetracycline minimum inhibitory concentrations ranged from 4 to ≥ 64 mg/L. Primers previously reported for the detection of tet(A) in Campylobacter failed to produce an amplicon using a positive control …