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Full-Text Articles in Life Sciences
Rampant Centrosome Amplification Underlies More Aggressive Disease Course Of Triple Negative Breast Cancers, Vaishali Pannu, Karuna Mittal, Guilherme Cantuaria, Michelle D. Reid, Xiaoxian Li, Shashikiran Donthamsetty, Michelle Mcbride, Sergey Klimov, Remus Osan, Meenakshi V. Gupta, Padmashree C.G. Rida, Ritu Aneja
Rampant Centrosome Amplification Underlies More Aggressive Disease Course Of Triple Negative Breast Cancers, Vaishali Pannu, Karuna Mittal, Guilherme Cantuaria, Michelle D. Reid, Xiaoxian Li, Shashikiran Donthamsetty, Michelle Mcbride, Sergey Klimov, Remus Osan, Meenakshi V. Gupta, Padmashree C.G. Rida, Ritu Aneja
Biology Faculty Publications
Centrosome amplification (CA), a cell-biological trait, characterizes pre-neoplastic and pre-invasive lesions and is associated with tumor aggressiveness. Recent studies suggest that CA leads to malignant transformation and promotes invasion in mammary epithelial cells. Triple negative breast cancer (TNBC), a histologically-aggressive subtype shows high recurrence, metastases, and mortality rates. Since TNBC and non- TNBC follow variable kinetics of metastatic progression, they constitute a novel test bed to explore if severity and nature of CA can distinguish them apart. We quantitatively assessed structural and numerical centrosomal aberrations for each patient sample in a large-cohort of grade-matched TNBC (n = 30) and non-TNBC …
Human Cytomegalovirus Interleukin-10 Promotes Proliferation And Migration Of Mcf-7 Breast Cancer Cells, Robin K. Bishop, Cendy A. Valle Oseguera, Juliet Spencer
Human Cytomegalovirus Interleukin-10 Promotes Proliferation And Migration Of Mcf-7 Breast Cancer Cells, Robin K. Bishop, Cendy A. Valle Oseguera, Juliet Spencer
Biology Faculty Publications
Breast cancer is the most common malignancy affecting women worldwide. While a small fraction of breast cancers have a hereditary component, environmental and behavioral factors also impact the development of cancer. Human cytomegalovirus (HCMV) is a member of the Herpesviridae family that is widespread in the general population and has been linked to several forms of cancer. While HCMV DNA has been found in some breast cancer tissue specimens, we wanted to investigate whether a secreted viral cytokine might have an effect on cancerous or even pre-cancerous cells. HCMV encodes an ortholog of the human cellular cytokine interleukin-10 (IL-10). The …