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Integrated Structural And Functional Analysis Of The Protective Effects Of Kinetin Against Oxidative Stress In Mammalian Cellular Systems, Muhammad Naseem, Eman M. Othman, Moustafa Fathy, Jibran Iqbal, Fares M. Howari, Fatima A. Alremeithi, Geema Kodandaraman, Helga Stopper, Elena Bencurova, Dimitrios Vlachakis, Thomas Dandekar
Integrated Structural And Functional Analysis Of The Protective Effects Of Kinetin Against Oxidative Stress In Mammalian Cellular Systems, Muhammad Naseem, Eman M. Othman, Moustafa Fathy, Jibran Iqbal, Fares M. Howari, Fatima A. Alremeithi, Geema Kodandaraman, Helga Stopper, Elena Bencurova, Dimitrios Vlachakis, Thomas Dandekar
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© 2020, The Author(s). Metabolism and signaling of cytokinins was first established in plants, followed by cytokinin discoveries in all kingdoms of life. However, understanding of their role in mammalian cells is still scarce. Kinetin is a cytokinin that mitigates the effects of oxidative stress in mammalian cells. The effective concentrations of exogenously applied kinetin in invoking various cellular responses are not well standardized. Likewise, the metabolism of kinetin and its cellular targets within the mammalian cells are still not well studied. Applying vitality tests as well as comet assays under normal and hyper-oxidative states, our analysis suggests that kinetin …