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Effect Of Administration Of Somatostatin Analogue On Blood Pressure In Chronic Intermittent Hypoxic Rats, Kajal Kamra
Effect Of Administration Of Somatostatin Analogue On Blood Pressure In Chronic Intermittent Hypoxic Rats, Kajal Kamra
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The cardiorespiratory system in our bodies does not adapt to Chronic Intermittent Hypoxia (CIH) and consequently syndromes such as sleep apnea lead to pathophysiological conditions like Hypertension. It has been demonstrated that the peripheral chemoreceptors underpin the development of these conditions and at present, there are no selective drug therapies for this form of hypertension. However, evidence suggests that peripheral chemoreflex sensitivity to CO2 & hypoxia is reduced by Somatostatin (SST) in humans. Our preliminary in-vitro studies have demonstrated that SST will blunt the response of the carotid body to hypoxia and decrease the baseline activity of the carotid body. …