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Full-Text Articles in Life Sciences
Investigation Of Exoribonuclease-1 Function In Regulation Of Stem Cells During Planarian Regeneration, Steven Gobinsing Sayson
Investigation Of Exoribonuclease-1 Function In Regulation Of Stem Cells During Planarian Regeneration, Steven Gobinsing Sayson
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Precise regulation of gene expression is crucial for the maintenance of pluripotency and proper differentiation of stem cells. Due to their exceptional capacity for stem cell-driven regeneration, planarians are ideal models to dissect mechanisms regulating gene expression that secure stem cell function in vivo. While mechanisms of transcriptional regulation of gene expression in stem cells have been extensively investigated, less is known about regulation at the post-transcriptional level. Exoribonuclease-1 (XRN-1) is a conserved enzyme in eukaryotes that catalyzes 5' to 3' exonucleolytic degradation of RNA. XRN-1 is known to be required for proper regeneration of Dugesia japonica. Here, I …
Characterization Of Sterility And Germline Defects Caused By Smed-Boule Rna-Interference, Jessica Kathryne Steiner
Characterization Of Sterility And Germline Defects Caused By Smed-Boule Rna-Interference, Jessica Kathryne Steiner
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Evolutionarily conserved molecular processes involved in construction of the germline and embryonic development are essential for the procreation of many species. Infertility affects 15% of couples in the world and can be caused by dysfunctions during egg and sperm development, anatomic defects, as well as faulty embryonic development. Although there are some infertility disorders that are genetically defined, such as Turner and Klinefelter syndromes, many clinical infertility cases are diagnosed as idiopathic due to the lack of understanding of basic fertility mechanisms. Schmidtea mediterranea is a freshwater planarian species that has the ability to regenerate complete organisms, including germ cells …