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Network-Based Approaches To Identify The Impacted Genes And Active Interactions, Sahar Ansari
Network-Based Approaches To Identify The Impacted Genes And Active Interactions, Sahar Ansari
Wayne State University Dissertations
A very important step in system biology is the identification of the networks that are most impacted in the given phenotype.
Such networks explain where the target genes are affected by some other genes, and therefore describe the mechanisms involved in a biological process.
The identified networks are used to: 1) predict the disease or the responses of the system to a specific impact, 2) find the subset of genes that interact with each other and play an important role in the condition of interest, and 3) understand the mechanisms involved in that condition.
In this thesis, we propose an …