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The Effects Of Carboxyl-Group Specific Modification And Triiodo-L-Thyronine On Cardiac Sodium Channels, Samuel C. Dudley
The Effects Of Carboxyl-Group Specific Modification And Triiodo-L-Thyronine On Cardiac Sodium Channels, Samuel C. Dudley
Theses and Dissertations
The patch clamp method was used to evaluate the effects of 3,5,3'-triiodo-L-thyronine (T3) and carboxyl modification on adult rabbit ventricular Na+ channels. In contrast to TTX-sensitive Na+ channels, Ca2+ block of cardiac Na+ channels was not prevented by selective carboxyl modification by trimethyloxonium (TMO) or water soluble carbodiimide (WSC). In 2 mM Ca2+, TMO-treated patches exhibited 3 discrete conductance (γNa) levels. An abbreviation of mean open time (MOT) accompanied each decrease in γNa. The effects on channel gating of elevating external Ca2+ differed from those of TMO …
Effects Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) On The In Vitro Antibody Response: Differential Effects On The B Lymphocyte Depending On The State Of In Vivo Activation And The Modulation By Serum-Derived Growth Factors, Dale L. Morris
Theses and Dissertations
Previous reports have indicated a dichotomy in the actions of TCDD on humoral immunity, both in vitro and in vitro, in which enhancements and suppression have been identified. The latter effect has been correlated with induction of liver P4501A1 enzyme activity, a response which is regulated by the Ah-gene locus. Additionally, the primary alteration in suppression of antibody responses is in the differentiation of the B cell. Therefore, the current investigation was undertaken to determine the relationship between these dual actions of TCDD on humoral immunity as related to its direct actions on B lymphocyte function. Specific emphasis was placed …