Life Sciences Commons^™

Expression Of Wnt-Signaling Pathway Genes And Their Associations With Mirnas In Colorectal Cancer, Martha L. Slattery, Lila E. Mullany, Lori C. Sakoda, Wade S. Samowitz, Roger K. Wolff, John R. Stevens, Jennifer S. Herrick

Mathematics and Statistics Faculty Publications

The Wnt-signaling pathway functions in regulating cell growth and thus is involved in the carcinogenic process of several cancers, including colorectal cancer. We tested the hypothesis that multiple genes in this signaling pathway are dysregulated and that miRNAs are associated with these dysregulated genes. We used data from 217 colorectal cancer (CRC) cases to evaluate differences in Wnt-signaling pathway gene expression between paired CRC and normal mucosa and identify miRNAs that are associated with these genes. Gene expression data from RNA-Seq and miRNA expression data from Agilent Human miRNA Microarray V19.0 were analyzed. We focused on genes most strongly associated …

Investigation Of Conical Spinneret In Generating More Dense And Compact Electrospun Nanofibers, Aya Hamed, Nader Shehata, Mohammad Elosairy

Biology Faculty Publications

Electrospinning is an important, widely used process to generate nanofibers. However, there is still an open window for different designs of both spinneret and collector electrodes to be investigated. This paper introduces the impact of new design of conical spinneret electrode on the generated electrospun nanofibers. In this work, the conical feeder is used to generate electrospun Poly(vinyl alcohol) (PVA) nanofibers, and being compared to the traditional needle feeder at the same processing conditions. The jet’s mechanism is simulated using discrete bead model along with estimated calculations of both deposition area and fiber radius. The electric field distribution that is …

Large Birds Of Prey, Policies That Alter Food Availability And Air Traffic: A Risky Mix For Human Safety, Rubén Moreno-Opo, Antoni Margalida

Human–Wildlife Interactions

Raptors are considered to pose one of the greatest aviation bird strike risk. We investigated raptor bird strikes reported at the largest Spanish airport (Adolfo Suárez Madrid Barajas; AS-MB) from 2009 to 2016 to determine the factors contributing to the increased incidences and develop recommendations to mitigate the risks. We hypothesized that increased raptor bird strikes resulted from changes in foraging and dispersal patterns of Iberian Peninsula vultures (Aegypius spp. and Gyps spp.) after 2004-2005. We used information on raptor bird strikes obtained from official databases and published studies, reported incidences of raptor bird strikes and their characteristics (i.e., …

Learning To Live With Wolves: Community-Based Conservation In The Blackfoot Valley Of Montana, Seth M. Wilson, Elizabeth H. Bradley, Gregory A. Neudecker

Human–Wildlife Interactions

We built on the existing capacity of a nongovernmental organization called the Blackfoot Challenge to proactively address wolf (Canis lupus)-livestock conflicts in the Blackfoot Valley of Montana. Beginning in 2007, wolves started rapidly recolonizing the valley, raising concerns among livestock producers. We built on an existing program to mitigate conflicts associated with an expanding grizzly bear population and worked within the community to build a similar program to reduce wolf conflicts using an integrative, multi-method approach. Efforts to engage the community included one-on-one meetings, workshops, field tours, and regular group meetings as well as opportunities to participate in …

Is Community-Based Conservation The Future Of Wildlife Management?, Terry A. Messmer

Human–Wildlife Interactions

This is the editors commentary

Small-Animal Models Of Zika Virus, Justin G. Julander, Venkatraman Siddharthan

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection can result in serious consequences, including severe congenital manifestations, persistent infection in the testes and neurologic sequelae. After a pandemic emergence, the virus has spread to much of the new world and has been introduced to many countries outside of endemic areas as infected travelers return to their home countries. Rodent models have been important in gaining a better understanding of the wide range of disease etiologies associated with ZIKV infection and for the initial phase of developing countermeasures to prevent or treat viral infections. We discuss herein the advantages and disadvantages of small animal models …

Seasonal Resource Selection And Habitat Treatment Use By A Fringe Population Of Greater Sage-Grouse, Rhett Boswell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Movement and habitat selection by Greater Sage-grouse (Centrocercus uropasianus) is of great interest to wildlife managers tasked with applying conservation measures for this iconic western species. Current technology has created small and lightweight GPS (Global Positioning Systems) transmitters that can be attached to sage-grouse. Using GIS software and statistical programs such as Program R, land managers can analyze GPS location data to assess how sage-grouse are geospatially interacting with their habitats. Within the Panguitch Sage-Grouse Management Area (SGMA) thousands of acres of land have been restored or manipulated to enhance sage-grouse habitat; this usually involves removal of pinyon pine …

Road Dust Correlated With Decreased Reproduction Of The Endangered Utah Shrub Hesperidanthus Suffrutescens, Matthew B. Lewis, Eugene W. Schupp, Thomas A. Monaco

Wildland Resources Faculty Publications

Roads associated with energy development have fragmented much of the Uinta Basin, the Colorado Plateau in general, and other areas of western North America. Beyond reducing available habitat, spreading exotic species, and creating barriers to dispersal, unpaved roads also increase dust loads on plants and pollinators, which may reduce plant growth and reproduction. We studied the effects of an unpaved road on reproduction of an endangered Utah endemic shrub. We measured the size and reproductive output of 156 plants and the dust deposition in plots at increasing distances from the road. We also hand outcrossed 240 flowers from 80 plants …

Fates Of Rare Species Under Siege From Invasion: Persistence Of Coccinella Novemnotata Herbst In Western North America Alongside An Invasive Congener, Edward W. Evans

Biology Faculty Publications

Species invading new geographic regions may threaten continued existence of similar, indigenous relatives, particularly those species whose rarity may reflect an already tenuous existence. The spectacular colonization of North America in recent decades by Coccinella septempunctata L. has generated widespread concern over potentially adverse effects on population viability of native species of ladybird beetles (Coccinellidae). Coccinella novemnotata Herbst in particular has been hypothesized to be at great risk, as this species apparently dwindled in numbers across much of North America during the twentieth century. Here results of sampling diverse habitats over three decades are examined to address the fate of …

Effect Of Sonication On The Viscosity Of Reconstituted Skim Milk Powder And Milk Protein Concentrate As Influenced By Solids Concentration, Temperature And Sonication, Vidita K. Desphande, M. K. Walsh

Nutrition, Dietetics, and Food Sciences Faculty Publications

Skim milk powder (SMP) and milk protein concentrates (MPCs) are manufactured by evaporation followed by spray drying and are widely used as functional and nutritional ingredients. This study investigated the effects of temperature (40–60 °C) and total solids content (TS) on the viscosity of reconstituted MPC (rMPC) (≥30% TS) and SMP (rSMP) (≥46% TS) in laboratory conditions. Additionally, the influence of sonication in batch (70% amplitude) and flow through systems (90% amplitude) was studied in a laboratory setting. The viscosity increased for all treatments with an increase in TS and decreased with an increase in temperature. Overall, sonication in both …

Sagestep News, Fall 2017, No. 31, Sagestep

Newsletters

Seasonal newsletter of SageSTEP.

Heritable Sperm Chromatin Epigenetics: A Break To Remember, Ralph G. Meyer, Chelsea C. Ketchum, Mirella L. Meyer-Ficca

UAES Publications

Sperm chromatin not only has a unique structure to condense and protect the paternal DNA in transit, but also provides epigenetic information that supports embryonic development. Most of the unique sperm nuclear architecture is formed during the sweeping postmeiotic chromatin remodeling events in spermiogenesis, where the majority of nucleosomes are removed and replaced by protamines. The remaining histones and other chromatin proteins are located in structurally and transcriptionally relevant positions in the genome and carry diverse post-translational modifications relevant to the control of embryonic gene expression. How such postmeiotic chromatin-based programming of sperm epigenetic information proceeds, and how susceptible the …

Efficacy Of Two Hortiled Fixtures, Jakob Johnson, Paul Kusuma, Bruce Bugbee

Controlled Environments

We tested the efficacy of the Full Spectrum and Red-Blue HORTILED TOP LED fixtures manufactured by PL Light. Both fixtures had an 80° light distribution.

The efficacy of the fixtures was measured using flat plane integration as described by Nelson and Bugbee (2014)¹ (see adjacent photo). The fixtures were suspended at 0.65 m above the floor in a 3 × 3 m room with flat black walls. The photosynthetic photon flux density (PPFD, μmol · m^-2 · s^-1) was measured with a recently calibrated quantum sensor (LI-COR model 190R). Measurements were made 2.5 cm apart near …

Integrating Social And Ecological Methods To Assess And Inform Park Monitoring And Management, Kelly A. Goonan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Managing outdoor recreation requires that managers do the following: (1) consider the user experience, environmental and cultural resources, and type and intensity of management actions; (2) specify desired conditions to be maintained, monitor conditions, and take appropriate action if unacceptable impacts occur; (3) adapt to new conditions and information; and (4) exercise good judgment based on their professional experience and the best information available to them. Social science studies of visitors and studies of significant recreation resources like campsites are important sources of information for managers and are commonly used in parks and protected areas to support planning and decision-making. …

Development Of An Animal Model For Enterovirus For Evaluation D68 For Screening Of Antiviral Therapies, W. Joseph Evans

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Enterovirus D68 (EV-D68) virus has become more prevalent over the last 15 to 20 years. EV-D68 attacks the respiratory system and can cause severe disease in individuals who have underlying respiratory problems. There have also been reports of individuals with EV-D68 showing signs of neurological system problems and acute flaccid paralysis. Because of the increase in patients with EV-D68 and also the potential for neurological disease, an animal model is needed to study the disease and to evaluate experimental therapies for EV-D68 infection.

To develop the animal model, 4-week old AG129 mice that lack alpha and beta interferon receptors, making …

The Biogeography And Nesting Biology Of Anthophora, With A Revision And Phylogeny Of The Anthophora (Micranthophora), Michael C. Orr

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Bees are necessary pollinators for a vast array of different plants, including many which we rely on for food. In order to grow sufficient crops to feed the world’s growing population, we need to make sure our crops are visited by the most effective possible pollinators. However, this is complicated by the fact that there are over 4,000 bee species in North America, many of which vary in their pollination effectiveness and are difficult to identify. My dissertation’s first two data chapters focus on classifying the species of the xeric solitary bee group Anthophora subgenus Micranthophora, including seven newly …

Non-Methane Hydrocarbon Source Apportionment And Btex Risk Assessment Of Winter 2015 In Roosevelt, Utah, Jerimiah Lamb

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Non-Methane Hydrocarbons (NMHC) monitored in Roosevelt Utah including Benzene, Toluene, Ethylbenzene and Xylene (collectively known as BTEX) are associated with deleterious effects including cancer. This study was designed to assess the origin and effect of the toxicants and addressed two points: 1) Source identification using the USEPA’s Positive Matrix Factorization (PMF) and NOAA’s Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model and 2) A human health risk assessment based on ambient concentrations of BTEX collected at the Roosevelt site. Model fit indicated that the primary contributor to total NMHCs was local oil and gas operations and was supported by previous …

Lactational Performance And Energy Partitioning Of Dairy Cows Supplemented With N-Acetyl-L-Methionine During Mid To Late Lactation, Tyson George Grisenti

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The N-acetyl-L-methionine (NALM) molecule is a methionine (Met) derivative produced via acetylation of the L-Met α-amino group with an N-acetyl group. This molecule has been shown to be bioavailable and capable of fulfilling the dietary requirement for Met in animals and humans. The current experiment was conducted to test a hypothesis that lactating dairy cows fed with NALM would increase milk production by increasing N and energy utilization efficiencies in a dose dependent manner. Eight multiparous Holstein cows that were mid lactation (124 ± 13 days-in-milk) with similar milk production were used in a 4 x …

Urban Bobcat (Lynx Rufus) Ecology In The Dallas-Fort Worth, Texas Metroplex, Julie M. Golla

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Urban landscapes are quickly replacing native habitat around the world. As wildlife and people increasingly overlap in their shared space and resources, so does the potential for human-wildlife conflict, especially with predators. Bobcats (Lynx rufus) are a top predator in several urban areas across the United States and a potential contributor to human-carnivore conflicts. This study evaluated the movements and habitat use of bobcats in the Dallas-Fort Worth (DFW), Texas metroplex. Spatial data were collected from 10 bobcats via Global Positioning Satellite (GPS) for approximately one year. Average home range size was 4.60 km² (n=9, SE=0.99 km …

Direct Effects Of Warming Increase Woody Plant Abundance In A Subarctic Wetland, Lindsay G. Carlson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Climate change is expected to continue to cause large increases in temperature in Arctic and sub-Arctic ecosystems which has already resulted in changes to plant communities; for example, increased shrub biomass and range. It is important to understand how warmer temperatures could affect the plant community in a wetland system because this region provides crucial high-quality forage for migratory herbivores during the breeding season. One mechanism by which warming could cause change is directly, where warming influences the vital rates of a species; these effects may be either positive or negative. Warmer temperatures may also affect a species indirectly, by …

Genetic Differentiation Of Two Species Of Buckwheat (Eriogonum), Jenessa Blotter Lemon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Limestone mining in the San Franicso Mountain Range of west central Utah threatens the survival of a rare endemic species of buckwheat (Eriogonum soredium). This species is an edaphic endemic, only found growing on the outcrops of the Ordovician limestone mines in the area. Eriogonum soredium is a candidate for governmental protection under the Endangered Species Act (ESA). However, a common, widespread buckwheat (Eriogonum shockleyi) appears to be closely related to the narrow endemic. The genetic relatedness of the rare and and common species will greatly influence the decision of United States Fish and Wildlife Service …

Nitrogen Availability And Use Efficiency In Corn Treated With Contrasting Nitrogen Sources, Avneet Kakkar

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The plant-soil nitrogen cycle plays a significant role in allocation of available N to plants, and improved understanding of N cycling helps sustainably increase fertilizer use efficiency. There are various processes (nitrogen mineralization and nitrification) involved in the availability and mobility of nitrogen in the soil. The primary objective of this study was to determine the NUE under contrasting nitrogen treatments over a period of five years. Additionally, we examined the effect of different N treatments on N mineralization and nitrification in conventional and organic farming systems.

This project was funded by Agriculture and Food Research Initiative Competitive Grants Program …

Toxicity And Mitochondrial Delivery Of Flavonol-Based Carbon Monoxide-Releasing Molecules, Hector Jose Esquer Heredia

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Despite the reputation of carbon monoxide (CO) as a silent killer, new evidence suggests that this gaseous molecule has anti-inflammatory, anti-cancer and vasoprotective properties. Unfortunately, little is known about the role of CO in the body. However, proteins present in mitochondria are believed to be important targets. We previously synthesized a class of novel and structurally modifiable flavonol-based CO-releasing molecules (CORMs). Flavonols are commonly found in fruits and vegetables. The base structure, Flav-1, is fluorescent, exhibits low toxicity, and releases CO after exposure to visible light. Previous reports indicate that addition of a triphenylphosphonium (TPP) tail allows chemical structures to …

Ecology Of Greater Sage-Grouse Inhabiting The Southern Portion Of The Rich-Morgan-Summit Sage-Grouse Management Area, M. Brandon Flack

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Greater sage-grouse (Centrocercus urophasianus; sage-grouse) are sagebrush obligates and are therefore considered to be key indicators of sagebrush ecosystem health. Sage-grouse populations have declined range-wide over the last century due to loss and fragmentation of sagebrush (Artemisia spp.) habitats. Sage-grouse populations found in large intact sagebrush landscapes are considered to be more resilient, however, some small isolated populations persist and thrive in fragmented landscapes. Because of Utah’s unique topography and geography, sage-grouse habitat is discontinuous and populations are naturally dispersed throughout the state in suitable intact blocks or in disconnected islands of sagebrush habitat. Thus, Utah populations …

Assessment Of Restoration Seedings On Utah Watershed Restoration Initiative Project Sites, Lacey E. Wilder

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Overabundance of shrubs poses a major threat to semiarid ecosystems due to degraded understory vegetation. Previous efforts suggest a need for greater understanding of which management practices work best to improve these ecosystems. I sought to develop a better understanding of how the relative performance of commonly seeded species is influenced by three sagebrush removal techniques.

I calculated effect sizes for cover and frequency to estimate relative changes in abundance of 15 common plant species seeded at 63 restoration sites throughout Utah. Shrubs were reduced by fire or mechanical treatment. Effect sizes were assessed using meta-analysis techniques for two post-treatment …

Seasonal Distribution Of Sage-Grouse In Hamlin Valley, Utah And The Effect Of Fences On Grouse And Avian Predators, Heather Hedden Mcpherron

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Greater sage-grouse (Centrocercus urophasianus; hereafter sage-grouse) numbers have declined throughout the western US and are considered a species of concern in most of the eleven states that are within their range. Sage-grouse habitats have been reduced by approximately 44% since European settlement of the Western United States began (Miller et al. 2011). Loss of habitat has contributed to an average decline of sage-grouse populations by 33% across the range (Connelly and Braun 1997). To expand our knowledge of this species, I monitored 16 radio-collared sage-grouse captured from four leks in Hamlin Valley, Utah, USA in 2011 and 2012 …

Northern Utah Turfgrass Management Calendar, Kelly Kopp, Michael Caron, Helen Muntz, Jaydee Gunnell

All Current Publications

This is a calendar for turfgrass management for northern Utah and includes guidelines for seeding, overseeding, sodding, fertilization, mowing, aeration, weed control, and irrigation.

Oystershell Scale Impacts And Mitigation Options On The Kaibab And Coconino Nf’S, Amanda M. Grady

Aspen Bibliography

This report documents a site visit to evaluate aspen stands experiencing oystershell scale damage on the Kaibab and Coconino National Forest’s. The site visit was requested by Kaibab NF, foresters including; Josh Giles, Jessi Outzs, Michael Sedgeman, Woody Rokala and Coconino Silviculturist, Mark Nabel. On November 19, 2016, Amanda Grady accompanied the individuals listed above, to evaluate stand conditions within three aspen exclosures. Two were located on the Williams Ranger District, Kaibab NF in the vicinity of Spring Valley. The third exclosure was located on the Flagstaff RD, Coconino NF and accessed from HWY 89-A via the Pump House Wash …

Preparing Soil For Turfgrass Establishment - Southern Utah, Michael Caron, Candace Schaible, Rick Heflebower, Grant Cardon, Taun Beddes, Kelly Kopp

All Current Publications

This fact sheet provides information for successfully establishing a lawn including planning, soil preparation, appropriate seed or sod choice, and an understanding of turfgrass requirements in southern Utah.

Verrucosis Del Duraznero, Claudia Nischwitz, Brent Black, Michael Pace

All Current Publications

No abstract provided.