Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Effect Of Sub-Inhibitory Wastewater Stressors On Mutation Frequency In Clinically Relevant Aeromonas Species, Brandon Michael Schultz
Effect Of Sub-Inhibitory Wastewater Stressors On Mutation Frequency In Clinically Relevant Aeromonas Species, Brandon Michael Schultz
Theses and Dissertations
Antimicrobial resistance among pathogens is steadily increasing resulting in untreatable infections and elevated mortality rates, with an estimation of claiming 10 million lives worldwide by 2050. A common factor accelerating resistance is the presence of sub-inhibitory microbial stressors (e.g. antimicrobials, heavy metals, and disinfectants), which can drive horizontal gene transfer and mutagenesis in various environments. Improper disposal of pharmaceuticals, excretion of antimicrobial byproducts from humans and livestock, and excess storm runoff are common sources of these pollutants. An environmental reservoir rich in stressors and bacterial populations, including the emerging pathogen Aeromonas, is wastewater. Our objective in this study was to …
Transcriptomics And Toxcast Data Identify Bioeffects In Zebrafish Embryos Exposed To Chemical Mixtures In An Effluent-Dominated Stream, Emma Meade
Theses and Dissertations
Wastewater treatment plant (WWTP) effluent-dominated streams provide critical habitat for aquatic organisms but also continually expose them to complex mixtures of pharmaceuticals and other contaminants of emerging concern (CECs) that can potentially impair growth, behavior, and reproduction. Limited toxicity data on the adverse biological impacts of in vivo exposure to these mixtures make it difficult to assess risk for aquatic organisms, particularly with respect to pharmaceuticals whose designed bioactivity often extends beyond conventionally monitored biological pathways. To address this knowledge gap, the goal of this thesis was to identify biomarkers of exposure to complex CEC mixtures relevant to specific chemicals …