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Full-Text Articles in Life Sciences
Targeting The Tumor Stroma: Integrative Analysis Reveal Gata2 And Toryaip1 As Novel Prognostic Targets In Breast And Ovarian Cancer, Ömer Faruk Erceylan, Ayşe Savaş, Esra Göv
Targeting The Tumor Stroma: Integrative Analysis Reveal Gata2 And Toryaip1 As Novel Prognostic Targets In Breast And Ovarian Cancer, Ömer Faruk Erceylan, Ayşe Savaş, Esra Göv
Turkish Journal of Biology
Tumor stroma interaction is known to take a crucial role in cancer growth and progression. In the present study, it was performed gene expression analysis of stroma samples with ovarian and breast cancer through an integrative analysis framework to identify common critical biomolecules at multiomics levels. Gene expression datasets were statistically analyzed to identify common differentially expressed genes (DEGs) by comparing tumor stroma and normal stroma samples. The integrative analyses of DEGs indicated that there were 59 common core genes, which might be feasible to be potential marks for cancer stroma targeted strategies. Reporter molecules (i.e. receptor, transcription factors and …
Transcriptomic Analysis Of Tomato Lines Reveals Putative Stress-Specific Biomarkers, Monther Taha Sadder, Abdullah Alsadon, Mahmoud Wahb-Allah
Transcriptomic Analysis Of Tomato Lines Reveals Putative Stress-Specific Biomarkers, Monther Taha Sadder, Abdullah Alsadon, Mahmoud Wahb-Allah
Turkish Journal of Agriculture and Forestry
Different abiotic stresses recruit dedicated signaling and regulatory genes in plants. Genome-wide stress-specific biomarkers were investigated in tomatoes. Three major abiotic stresses were compared: drought, heat, and salinity. For each stress type, 2 different tomato lines were included: susceptible and tolerant. Gene expression was examined by hybridizing to an available tomato microarray. Several stress responsive genes were upregulated in tolerant as well as in susceptible lines for each stress. Comparative analysis of gene expression in response to stress (drought, heat, or salinity) resolved a number of common biomarkers, while other groups of putative biomarkers were associated with each abiotic stress. …
Current Paradigms Of Cancer Chemoprevention, Rajendra G. Mehta
Current Paradigms Of Cancer Chemoprevention, Rajendra G. Mehta
Turkish Journal of Biology
Cancer chemoprevention has been continually evolving ever since the term was coined in the 70s. From the original approaches of identifying chemopreventive agents from the dietary constituents based on the epidemiological data to the current status of adapting them from the molecular targets, significant understanding of cancer as a disease and its possible prevention has been achieved. The identification of the chemopreventive agent from a complex mixture of natural product extracts involves numerous steps including bioassay guided fractionation; evaluation of the extracts, fractions and isolated new chemicals selectively using in vitro and in vivo experimental models; and understanding the mechanism …
Progesterone Receptor Modulators In Breast Cancer, Ronald D. Wiehle
Progesterone Receptor Modulators In Breast Cancer, Ronald D. Wiehle
Turkish Journal of Biology
Breast cancer has been treated successfully with selective estrogen receptor antagonists (SERMs) such as tamoxifen, receptor-depleting agents such as fulvestrant, and aromatase inhibitors such as anastrozole. Selective progesterone receptor modulators (SPRMs or PRMs) have not been studied as much and are currently under investigation for inhibition of mammary carcinogenesis in animal models and breast cancer prevention trials in women. They might follow tamoxifen and aromatase inhibitors in the adjuvant treatment of breast cancers with acquired resistance. These uses have not provoked ground-breaking progress or studies and PRMs do not have a high profile. Most in vitro and in vivo studies …
Biomarkers Of Petroleum Contamination In The Digestive Gland Of Perna Viridis (L.), Xivanand Narayan Verlecar, Karmabeer Jena, Somshekher Raghoba Desai, Priya Brata Das, Gagan Bihari Nityananda Chainy
Biomarkers Of Petroleum Contamination In The Digestive Gland Of Perna Viridis (L.), Xivanand Narayan Verlecar, Karmabeer Jena, Somshekher Raghoba Desai, Priya Brata Das, Gagan Bihari Nityananda Chainy
Turkish Journal of Biology
Oxidative stress responses were evaluated in the digestive gland tissue of Perna viridis exposed to water-accommodated fractions (WAFs) of petrol and diesel at 0.5% and 5% concentrations over 5-, 10-, and 15-day periods. Increased lipid peroxidation, protein carbonyl, DNA integrity, and hydrogen peroxide in WAF-exposed specimens are indicative of oxidative damage due to dissolved petroleum extracts. A consistent increase in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, reduced glutathione, and ascorbic acid in WAF-exposed specimens signify the importance of antioxidants in protecting the cell against the oxidative damage arising from petroleum contamination. The responses of field specimens collected from …