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A Comparative Study On Morphochemical Properties And Osteogenic Cell Differentiation Within Bone Graft And Coral Graft Culture Systems., Puvaneswary S, Balaji Raghavendran Hr, Ibrahim Ns, Murali Mr, Merican Am, Kamarul T
A Comparative Study On Morphochemical Properties And Osteogenic Cell Differentiation Within Bone Graft And Coral Graft Culture Systems., Puvaneswary S, Balaji Raghavendran Hr, Ibrahim Ns, Murali Mr, Merican Am, Kamarul T
Murali Malliga Raman
The objective of this study was to compare the morphological and chemical composition of bone graft (BG) and coral graft (CG) as well as their osteogenic differentiation potential using rabbit mesenchymal stem cells (rMSCs) in vitro. SEM analysis of BG and CG revealed that the pores in these grafts were interconnected, and their micro-CT confirmed pore sizes in the range of 107-315 µm and 103-514 µm with a total porosity of 92% and 94%, respectively. EDS analysis indicated that the level of calcium in CG was relatively higher than that in BG. FTIR of BG and CG confirmed the presence …
Pva-Chitosan Composite Hydrogel Versus Alginate Beads As A Potential Mesenchymal Stem Cell Carrier For The Treatment Of Focal Cartilage Defects: An In Vivo Study Using Rabbits, Dashtdar H, Murali Mr, Abbas Aa, Suhaeb Am, Selvaratnam L, Tay Lx, Kamarul T
Pva-Chitosan Composite Hydrogel Versus Alginate Beads As A Potential Mesenchymal Stem Cell Carrier For The Treatment Of Focal Cartilage Defects: An In Vivo Study Using Rabbits, Dashtdar H, Murali Mr, Abbas Aa, Suhaeb Am, Selvaratnam L, Tay Lx, Kamarul T
Murali Malliga Raman
PURPOSE: To investigate whether mesenchymal stem cells (MSCs) seeded in novel polyvinyl alcohol (PVA)-chitosan composite hydrogel can provide comparable or even further improve cartilage repair outcomes as compared to previously established alginate-transplanted models. METHODS: Medial femoral condyle defect was created in both knees of twenty-four mature New Zealand white rabbits, and the animals were divided into four groups containing six animals each. After 3 weeks, the right knees were transplanted with PVA-chitosan-MSC, PVA-chitosan scaffold alone, alginate-MSC construct or alginate alone. The left knee was kept as untreated control. Animals were killed at the end of 6 months after transplantation, and …