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Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Sex Steroid Metabolism Polymorphisms And Mammographic Density In Pre- And Early Perimenopausal Women, Carolyn J. Crandall, Mary E. Sehl, Sybil L. Crawford, Ellen B. Gold, Laurel A. Habel, Lesley M. Butler, Mary Fran R. Sowers, Gail A. Greendale, Janet S. Sinsheimer
Sex Steroid Metabolism Polymorphisms And Mammographic Density In Pre- And Early Perimenopausal Women, Carolyn J. Crandall, Mary E. Sehl, Sybil L. Crawford, Ellen B. Gold, Laurel A. Habel, Lesley M. Butler, Mary Fran R. Sowers, Gail A. Greendale, Janet S. Sinsheimer
Sybil L. Crawford
INTRODUCTION : We examined the association between mammographic density and single-nucleotide polymorphisms (SNPs) in genes encoding CYP1A1, CYP1B1, aromatase, 17beta-HSD, ESR1, and ESR2 in pre- and early perimenopausal white, African-American, Chinese, and Japanese women. METHODS : The Study of Women's Health Across the Nation is a longitudinal community-based cohort study. We analyzed data from 451 pre- and early perimenopausal participants of the ancillary SWAN Mammographic Density study for whom we had complete information regarding mammographic density, genotypes, and covariates. With multivariate linear regression, we examined the relation between percentage mammographic breast density (outcome) and each SNP (primary predictor), adjusting for …
Factors Related To Declining Luteal Function In Women During The Menopausal Transition, Nanette Santoro, Sybil L. Crawford, Bill Lasley, J. L. Luborsky, Karen A. Matthews, Daniel Mcconnell, John F. Randolph, Ellen B. Gold, Gail A. Greendale, S. G. Korenman, Lynda H. Powell, Mary Fran R. Sowers, Gerson Weiss
Factors Related To Declining Luteal Function In Women During The Menopausal Transition, Nanette Santoro, Sybil L. Crawford, Bill Lasley, J. L. Luborsky, Karen A. Matthews, Daniel Mcconnell, John F. Randolph, Ellen B. Gold, Gail A. Greendale, S. G. Korenman, Lynda H. Powell, Mary Fran R. Sowers, Gerson Weiss
Sybil L. Crawford
CONTEXT: Reproductive hormones are incompletely characterized during the menopause transition (MT). Hypothesis: Increased anovulation and decreased progesterone accompany progress through the MT. DESIGN: The Daily Hormone Study (DHS) of the Study of Women's Health Across the Nation (SWAN) included 848 women aged 43-53 yr at baseline who collected daily urine for one cycle or up to 50 d annually for 3 yr. MAIN OUTCOME MEASURES: LH, FSH, estrone conjugates, and pregnanediol glucuronide levels were assessed. Cycles were classified by presumed luteal (ovulatory) status and bleeding. Hormones were related to time in study, age, menopausal status, and selected variables. RESULTS: Ovulatory-appearing …
Design And Methods For A Randomized Clinical Trial Treating Comorbid Obesity And Major Depressive Disorder, Kristin L. Schneider, Jamie S. Bodenlos, Yunsheng Ma, Barbara C. Olendzki, Jessica Oleski, Philip A. Merriam, Sybil L. Crawford, Ira S. Ockene, Sherry L. Pagoto
Design And Methods For A Randomized Clinical Trial Treating Comorbid Obesity And Major Depressive Disorder, Kristin L. Schneider, Jamie S. Bodenlos, Yunsheng Ma, Barbara C. Olendzki, Jessica Oleski, Philip A. Merriam, Sybil L. Crawford, Ira S. Ockene, Sherry L. Pagoto
Sybil L. Crawford
BACKGROUND: Obesity is often comorbid with depression and individuals with this comorbidity fare worse in behavioral weight loss treatment. Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial. METHODS AND DESIGN: This randomized clinical trial will examine whether behavior therapy for depression administered prior to standard weight loss treatment produces greater weight loss than standard weight loss treatment alone. Obese women with major depressive disorder (N = 174) will be recruited from primary care clinics and the community and randomly …