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Articles 1 - 30 of 58
Full-Text Articles in Life Sciences
345 - The Effects Of Alcohol And Ketogenic Diet On Working Memory In Mice, Kaitlyn Dufresne, Sophia Azurin, Allison Bechard
345 - The Effects Of Alcohol And Ketogenic Diet On Working Memory In Mice, Kaitlyn Dufresne, Sophia Azurin, Allison Bechard
GREAT Day Posters
The ketogenic diet (KD) is a high fat, low carb diet which is growing in popularity as a possible method to improve working memory and prevent alcohol use disorder (AUD). We used a mouse model where half of the mice were fed a standard diet (SD) while the other half were fed the KD. All mice experienced a 7 week drinking period where they were introduced to alcohol for 2 hours, 3 days a week. We then tested the mice in a working memory task. We modeled working memory using the Barnes maze. Mice escaped to a target hole in …
352 - Quantifying Variation Of The Ostrich Wing (Aves: Paleognathae), Isabel Marzec
352 - Quantifying Variation Of The Ostrich Wing (Aves: Paleognathae), Isabel Marzec
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The common Ostrich (Struthio camelus) is a member of a large clade of flightless birds known as the ratites. The ratites are morphologically classified by their absence of a keeled sternum that, in flighted birds, provides a large surface area for flight muscle attachment. Although morphology in flighted birds is relatively constrained, the lack of selective pressures in ratites has led to increased variability in the wing. The skeleton of S. camelus exhibits numerous adaptations related to cursoriality, such as a double patella, shortened wing skeleton, and a lightweight pelvic girdle. Though their wings may not be capable …
245 - P27kip1 Is Upregulated In Umscv-4 Cells Corresponding To Entering A State Of Quiescence When Treated With Clobetasol., Gianna Minnuto, Luke North, Mack Ogden, Kia Haering
245 - P27kip1 Is Upregulated In Umscv-4 Cells Corresponding To Entering A State Of Quiescence When Treated With Clobetasol., Gianna Minnuto, Luke North, Mack Ogden, Kia Haering
GREAT Day Posters
Quiescence, the temporary exit from the cell cycle, presents therapeutic challenges to cancer management since it allows evasion of chemotherapy and radiotherapy treatment. Essential to the study of quiescence in carcinogenesis is an established model system. Our studies have found that clobetasol treatment of the vulvar cancer cell line, UMSCV-4 causes these cells to enter a state of dormancy. Subsequent removal of the cells from clobetasol show a return to normal cell proliferation, even after dormancy for 3 months. p27Kip1 protein is elevated in quiescent cells and has been used as a marker for entry into quiescence. Using both …
122 - Using Crispr/Cas9 Genome Editing To Knockout Mhc Class I In Xenopus Laevis, Keely Glasheen, David Marx, Jacques Robert
122 - Using Crispr/Cas9 Genome Editing To Knockout Mhc Class I In Xenopus Laevis, Keely Glasheen, David Marx, Jacques Robert
GREAT Day Posters
The immune system of the frog Xenopus laevis is similar to humans. MHC Class I is a vital molecule for the immune system of Xenopus laevis. It presents peptides to CD8 T-cells and the presentation of self peptide fragments is crucial for immune self recognition. When MHC Class I presents non-self peptide fragments, it triggers an immune response, causing CD8 T-cells to kill the infected cells. All cells express some level of MHC Class I because all cells can be infected. The role this molecule plays in immune function and self recognition is of particular interest in Xenopus laevis since …
193 - Biological Trends In Schistosomiasis Reinfections And Co-Infections, David Marx, Tyler Dzuba, Wai Cheung Tung
193 - Biological Trends In Schistosomiasis Reinfections And Co-Infections, David Marx, Tyler Dzuba, Wai Cheung Tung
GREAT Day Posters
Schistosomiasis is a parasitic infection that affected nearly 252 million people worldwide in 2021, Africa, Asia, and South America are the most affected regions. Schistosomiasis can cause many symptoms, many of which are seen through urinalysis. Due to the nature of Schistosoma mansoni and S. haematobium reinfection is quite common. Coinfection also between these two species occurs frequently due to the overlap in areas they affect. Both reinfection and coinfection are possible causes for differences in severity of infection. The severity of infection can be determined both in terms of the symptoms of the afflicted individual as well as looking …
204 - How Does Change In Land Use Impact The Water Chemistry Parameters In The Streams Of Oswego County, Ny, Madison Steates, Thomas Back
204 - How Does Change In Land Use Impact The Water Chemistry Parameters In The Streams Of Oswego County, Ny, Madison Steates, Thomas Back
GREAT Day Posters
Land use within a watershed is closely tied to stream water chemistry. Anthropogenic chemical inputs eventually make their way into streams, affecting fluvial ecosystems. Sources of these anthropogenic inputs change over time, especially when rural landscapes become increasingly urbanized. We studied the relationship between land use and stream water chemistry for Oswego County, New York, because riparian zones in this county have shifted to residential from agricultural and forested land uses. We extracted data from the New York State Department of Conservation (DEC) Department of Water (DOW) Monitoring Portal. Preliminary results show that Total Nitrogen (Kjeldahl) in mg/L fluctuates yearly …
237 - Seasonal And Historical Trends Of Cyanobacteria Dominance In Conesus Lake, Emma Belica, Isabella Imbo
237 - Seasonal And Historical Trends Of Cyanobacteria Dominance In Conesus Lake, Emma Belica, Isabella Imbo
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The purpose of this research was three-fold. First, an analysis of long-term data was conducted to determine how the abundance of the cyanobacteria of the genus Dolichospermum changed historically since 1985 in Conesus Lake. Secondly, to look at the seasonality of the Dolichospermum blooms in the Summer of 2022. Third, to determine Dolichospermum's Nitrogen-fixing activity based on analysis of the frequency of Nitrogen-fixing cells in the population (heterocysts). Long-term data shows Dolichospermum has increased in representation in recent years and in 2022 reached a peak biomass that represented 75% of all the cyanobacteria biomass and 56% of all the phytoplankton …
116 - The Effects Of Tetrahydrocannabinol On Circadian Rhythmicity And The Response To Nicotine In Long-Evans Rats, Lauren Mac Taggart, Anna Hendricks, Joey Morgan, Vincent Markowski
116 - The Effects Of Tetrahydrocannabinol On Circadian Rhythmicity And The Response To Nicotine In Long-Evans Rats, Lauren Mac Taggart, Anna Hendricks, Joey Morgan, Vincent Markowski
GREAT Day Posters
The marijuana legalization trend promotes the notion that cannabinoids such as tetrahydrocannabinol (THC) can be safe and effective medications for conditions such as insomnia. Unfortunately, exposure to THC during development has been shown to impair cognition and motor behavior in humans and laboratory animals. The current study used VitalView software and cage-top infrared activity monitors to quantify the effects of a range of THC doses on activity and circadian rhythms in adult rats that were exposed to THC throughout adolescence. Rats were further administered acute nicotine drug challenges to determine if THC altered the development of the acetylcholine neurotransmitter system. …
146 - Localization Of Sonic Hedgehog (Shh) Protein In Zebrafish, Muwafuq Ibrahim, Jacqueline Maloney, Christopher Jung, Zee Ralph, Isabell Mathew
146 - Localization Of Sonic Hedgehog (Shh) Protein In Zebrafish, Muwafuq Ibrahim, Jacqueline Maloney, Christopher Jung, Zee Ralph, Isabell Mathew
GREAT Day Posters
Zebrafish possess a unique ability to regenerate their retina when damaged; our objective is to gain a better understanding regarding retinal regeneration in zebrafish in hopes of eventually utilizing this information to promote retinal regeneration in humans. It has been shown that a protein, Sonic Hedgehog signaling protein (shh), plays a role in the differentiation of progenitor cells during eye development in zebrafish. Researchers have concluded that shh moves across the retina in a wave-like fashion during vertebrate development and regeneration. Studies have been conducted to see how the shh protein moves, but none have investigated the exact location that …
129 - Analysis Of Corpus Callosum And Ventricles In Brain Tissue Of Mk801/Cdppb Treated C57bl6/J Mice, Ryan Pelkey, Noah Massey, Evan Eshenaur, Zander Purcell, Vincent Markowski
129 - Analysis Of Corpus Callosum And Ventricles In Brain Tissue Of Mk801/Cdppb Treated C57bl6/J Mice, Ryan Pelkey, Noah Massey, Evan Eshenaur, Zander Purcell, Vincent Markowski
GREAT Day Posters
The neurodevelopmental hypothesis depicts schizophrenia as a long-term consequence of aberrant development of the glutamate and dopamine neurotransmitter systems during the perinatal period. The drug MK-801 is a glutamate N-methyl-D-aspartate (NMDA) receptor antagonist that produces schizophrenia-like symptoms in laboratory rodents when administered early in development. Our laboratory has been investigating whether CDPPB, a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), would reverse the effects of MK-801. To test this, mice were first administered 0.25 mg/kg MK-801 as neonates, and later given 10.0 mg/kg CDBBD or saline during their juvenile period. Previously, our lab found that MK-801 produced …
126 - The Effects Of Perinatal Or Peripubertal Exposure To Tetrahydrocannabinol On Developmental Milestones, Motor Behavior, And Somatosensation In Rats, Anna Hendricks, Lindsey Toole, Allyson Surowick, Danielle Roemer, Vincent Markowski
126 - The Effects Of Perinatal Or Peripubertal Exposure To Tetrahydrocannabinol On Developmental Milestones, Motor Behavior, And Somatosensation In Rats, Anna Hendricks, Lindsey Toole, Allyson Surowick, Danielle Roemer, Vincent Markowski
GREAT Day Posters
Tetrahydrocannabinol (THC) is the primary psychoactive agent in marijuana, one of the most popular recreational drugs in the world. As the legalization trend in the U.S. expands, more women are consuming THC during pregnancy and more teens are experimenting with the drug. Unfortunately, the effects of THC on fetal and adolescent brain development are poorly understood. The current study was designed to identify the developmental and somatomotor effects of THC exposure. Long-Evans rats were assigned to one of two cohorts: prenatal exposure where pregnant rats were administered THC from gestational day 1 to postnatal day 21 or juvenile exposure where …
178 - Ketogenic Diet And Social Behavior In A Mouse Model Of Autism Spectrum Disorder, Macy Kuebler, Abigail Grzeskowiak, Emily Trabulsi, Abigail Schwartzman, Gabrielle Skiba
178 - Ketogenic Diet And Social Behavior In A Mouse Model Of Autism Spectrum Disorder, Macy Kuebler, Abigail Grzeskowiak, Emily Trabulsi, Abigail Schwartzman, Gabrielle Skiba
GREAT Day Posters
Impaired social interaction is one of three key diagnostic criteria for Autism Spectrum Disorder (ASD). Other criteria for ASD include repetitive behavior and impaired communication skills. This developmental condition is increasing within the United States, yet no cure is currently available. Ketogenic diet (KD) is a high fat, low carb diet proven to help many neurological issues in humans and reduce repetitive behavior in the mouse model. This study uses a FVB mouse model predisposed to developing stereotypical behaviors, specifically, repetitive circling to investigate the effects of KD on social and repetitive behavior. Subjects were old and young mice fed …
162 - The Importance Of Chaf-1b And P53 In Zebrafish Apoptosis, Noé Stephens, Dhavan Brahmbhatt, Isabel Reitano-Stayer, Hannah Haws
162 - The Importance Of Chaf-1b And P53 In Zebrafish Apoptosis, Noé Stephens, Dhavan Brahmbhatt, Isabel Reitano-Stayer, Hannah Haws
GREAT Day Posters
Chromatin assembly factor-1b (Caf-1b), one of the subunits of Chromatin assembly factor-1, is integral for retina differentiation in both humans and zebrafish. Fisher et. al found that apoptosis was stimulated in cells that lack Caf-1b at the S-phase check point by the tumor suppressor p53 as cells that lacked Caf-1b had a much higher expression of p53 then cells that contained Caf-1b. Fisher et. al proposed the model that Caf-1b is an inhibitor of p53 which stimulates apoptosis in the absence of Caf-1b (2007). However, it is not known what occurs when both Caf-1b and p53 are both removed. If …
256 - Development Of Molecular Markers From The Transcriptome Of An Ant-Mimicking Spider For Population Genetic Analyses, Anna Schell
GREAT Day Posters
The ant-mimicking spider, Myrmarachne formicaria, is a species of jumping spider that is native to Eurasia but has been sighted in North America starting in 2001. This spider is distinctive because of the way it imitates ants by moving its front two legs around like an ant’s antennae. As it is not native to North America, it must have been introduced to the country, but there is not currently enough information to determine whether there was only one introduction event or several different events. We can distinguish between these scenarios and learn more about this spider's dispersal history by analyzing …
242 - Validating Zebrafish Chaf1b Antibody, Brianna Donlon, Stephen Welsch, Emma Hatch
242 - Validating Zebrafish Chaf1b Antibody, Brianna Donlon, Stephen Welsch, Emma Hatch
GREAT Day Posters
Zebrafish embryos that are homozygous for gef mutant alleles experience a small-eye phenotype, due to a coding change in the chaf1b gene that results in a prematurely truncated protein. It's thought that the Chaf1b protein is required for all dividing cells to survive the DNA replication phase of the cell cycle. Contradicting these findings, the proliferating cells of the gef mutant embryos do not start to prematurely die until they are two days old. One question of delayed death in zebrafish is whether the normal protein can be provided by the heterozygous mother. If so, this would account for how …
055— Ketogenic Diet And Dendritic Morphology In A Mouse Model Of Repetitive Behavior, Samantha Seeger, Yume Iriyama, Allison R. Bechard
055— Ketogenic Diet And Dendritic Morphology In A Mouse Model Of Repetitive Behavior, Samantha Seeger, Yume Iriyama, Allison R. Bechard
GREAT Day Posters
Repetitive motor behaviors are invariant movements with no apparent function. They are associated with several disorders, including autism spectrum disorders (ASD). However, little is known about the causes of these restricted behavior patterns, and effective treatments are lacking. ASD has recently been treated with a ketogenic diet (KD). Now a popular fad, KD is a high-fat, low-carb diet that has treated intractable epilepsy for decades. However, the mechanisms mediating KD’s beneficial effects are still unclear. We first show KD can attenuate repetitive circling behavior. We then assessed dendritic spine density in the left and right dorsolateral striatum as a potential …
355— Topographical Individualized Neuromarkers In The Analysis Of The Brain Functioning Of Social-Emotional Development, Maya Pellitteri, Daniella Leone, Emma Piwko, Michael Schulz, Sarina Singh, Bradley Taber-Thomas
355— Topographical Individualized Neuromarkers In The Analysis Of The Brain Functioning Of Social-Emotional Development, Maya Pellitteri, Daniella Leone, Emma Piwko, Michael Schulz, Sarina Singh, Bradley Taber-Thomas
GREAT Day Posters
Topographical Individualized Neuromarkers (TIN) are spatially arranged patterns of brain function used to develop novel brain markers of social-emotional functioning and development. The current study focuses on developing markers of risk for psychological problems in children. We are expanding on previous research that indicates the brains of shy children differ from the brains of non-shy children, where shy children present with a topographical pattern of brain function that may be considered an internally hypervigilant neuromarker (Taber-Thomas et al., 2016). Using the online software, Neurosynth, we will extend our research into neuromarkers for other disorders using publicly available data. This program …
041— Fiber Decomposition And Pretreatment Analysis Of Cannabis Sativa L.: Hemp, Dina Bu, Jessica Roggie, Sarah Schmidlin, Barnabas Gikonyo
041— Fiber Decomposition And Pretreatment Analysis Of Cannabis Sativa L.: Hemp, Dina Bu, Jessica Roggie, Sarah Schmidlin, Barnabas Gikonyo
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Hemp is a subspecies of Cannabis sativa L. along with marijuana, yet the two differ in chemical constituent levels of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Hemp contains 0.3% THC, compared to marijuana 17.1%, allowing it to be a safe and compelling biomass for investigation. The refined products of hemp are vast due to its fast-growing properties; therefore various commercial industries have included refined hemp in biofuels, biodegradable plastics, textiles, dietary supplements, paper, clothing, and much more. Construction and manufacturing applications have also been seen to include hemp to strengthen their composite products. The high-yielding, sustainable, and environmentally friendly qualities …
085— Success Of Batesian Mimicry In The Ant-Mimicking Spider Myrmarachne Formicaria, Niaomi Vanalstine, Julia Ophals
085— Success Of Batesian Mimicry In The Ant-Mimicking Spider Myrmarachne Formicaria, Niaomi Vanalstine, Julia Ophals
GREAT Day Posters
Myrmarachne formicaria (Salticidae) is an ant-mimicking spider which arrived in North America fairly recently, first noted in Ohio in 2001. It is important to understand how M. formicaria will impact other species as it spreads throughout North America. The goal of this study was to assess the success of Batesian mimicry used by the ant-mimicking spider in avoiding predation when in a staged encounter with another salticid spider. Myrmarachne formicaria mimic ants in the movement of their forelegs to resemble ant antennae, as well as bob their abdomen. The predator spiders were placed in a small petri dish with either …
042— Pretreatment And Fiber Content Analysis Of Cannabis Sativa L. Part Ii., Jessica Roggie, Dina Bu, Sarah Schmidlin
042— Pretreatment And Fiber Content Analysis Of Cannabis Sativa L. Part Ii., Jessica Roggie, Dina Bu, Sarah Schmidlin
GREAT Day Posters
Cannabis Sativa L., more commonly known as hemp, has become one of the fastest-growing plants whose refined products have immense commercial value. Various products such as: biofuels, biodegradable plastics, textiles, dietary supplements, paper, clothing and more include refined hemp in their composition. Hemp fibers are also used in construction and manufacturing applications as a way to strengthen composite products. The various qualities of hemp make it a high yielding, sustainable, and environmentally friendly crop which has the potential to yield valuable raw materials for a great number of applications. Our research evaluates the pretreatment of hemp as well as the …
216— Loss Of Function Mutation For Tp53 Does Not Rescue The Chaf1bNt2 Small-Eye Phenotype In Danio Rerio, Alex Parks
216— Loss Of Function Mutation For Tp53 Does Not Rescue The Chaf1bNt2 Small-Eye Phenotype In Danio Rerio, Alex Parks
GREAT Day Posters
In Zebrafish, the chromosome assembly factor 1b (chaf1b) gene is in part responsible for the development of the eye. In homozygous chaf1bt24412 mutants retinal cell death is promoted through cell-death promoting activity of the gene, tumor suppressor protein p53 (tp53), resulting in a small-eye phenotype. Another allele chaf1bnt2, was found to also result in the small-eye phenotype when in a homozygous state. We found that knockdown of Tp53 protein via morpholino antisense oligonucleotide injection of 1-2 cell stage embryos failed to rescue retinal cell death of chaf1bnt2 homozygous mutants as detected by TUNEL labeling. Because morpholinos may fail to fully …
208— Describing Genetic Diversity In A Non-Native Ant-Mimicking Spider, Cassidy Mills, Jennifer L. Apple
208— Describing Genetic Diversity In A Non-Native Ant-Mimicking Spider, Cassidy Mills, Jennifer L. Apple
GREAT Day Posters
The ant-mimicking spider Myrmarachne formicaria (Salticidae) is a species native to Eurasia and was first identified in North America in 2001. It has since been found in many locations in the Northeast including western New York, western Pennsylvania, northeastern Ohio, and southern Ontario. Little is known about its introduction to North America and how it has dispersed since. By characterizing the mitochondrial genetic diversity of this species, we can learn about its introduction history and dispersal patterns in North America. Sequencing of a 600-bp mitochondrial DNA gene region spanning the 16s rRNA, leucine tRNA, and part of the ND1 gene …
307— Cooperation Of Selfish Genetic Elements In Stalk-Eyed Flies, Suhani Patel, Ben Mcpherson
307— Cooperation Of Selfish Genetic Elements In Stalk-Eyed Flies, Suhani Patel, Ben Mcpherson
GREAT Day Posters
SGEs are selfish genetic elements that increase the likelihood of their own transmission regardless of the host’s best interest. Transposable elements (TEs) and meiotic drivers are both types of SGEs. SGEs subsequently result in genetic conflict as they disrupt functional elements in the genome. We are working to better understand the cooperation of selfish genetic elements in Stalk-Eyed flies. Transposable elements are counteracted by small non-coding RNA molecules called piRNA. These RNA molecules work by reducing the expression of TEs by degrading TE RNA transcripts. Prior work in stalk-eyed flies has shown that TEs are expressed at a higher rate …
305— Effects Of Anthropogenic Noise On Frog Breeding Populations In Geneseo, Jack Barbosa, Robert Colbath, Lydia Gleason
305— Effects Of Anthropogenic Noise On Frog Breeding Populations In Geneseo, Jack Barbosa, Robert Colbath, Lydia Gleason
GREAT Day Posters
With both amphibians and their wetland habitats in decline, it is critical to understand what ponds in the local landscape are used as breeding sites. Male frogs advertise for mates in the spring and summer by producing species-specific vocalizations at potential breeding sites. We are using acoustic recordings to examine three local sites for their use for breeding by frogs. Acoustic recordings collected during May 2020 will be analyzed to determine species abundance based on the temporal patterns of activity. By analyzing how the soundscapes and holistic metric of the habitats differ between sites can we understand the frogs' habits. …
215— Schistosomiasis Infections In School Aged Children In Ghana, Katerina Pisciotta, Maia Mazzaferro
215— Schistosomiasis Infections In School Aged Children In Ghana, Katerina Pisciotta, Maia Mazzaferro
GREAT Day Posters
Schistosomiasis is a Neglected Tropical Disease caused by a parasitic blood fluke. There are currently over 240 million people affected globally. Humans become infected after coming into contact with water containing the infectious stage of the parasite. Our data consists of egg counts for Schistosoma haematobium and Schistosoma mansoni collected from school-aged children in Tomefa, Ghana, a marginalized informal community, between 2014 and 2019. Our research explores whether or not reinfections and continuous infections were occurring over the six-year period. Although the government conducts periodic mass drug administration, reinfections are likely given the social and environmental conditions in the community. …
281— Insect Soundscapes In Western New York, Sarah Metz, Mackenzie Bancroft, Dana Moukaled
281— Insect Soundscapes In Western New York, Sarah Metz, Mackenzie Bancroft, Dana Moukaled
GREAT Day Posters
Recent assessments of insect populations suggest significant declines in abundance and diversity across the globe. These assessments have not included western New York, so it is important to gain an understanding of the insect diversity and abundance in our local habitats, particularly grasslands. One noninvasive way to sample insect populations is to record the acoustic signals used by these animals. Male insects of several taxa advertise for mates in the late summer by producing species-specific vocalizations at potential breeding sites. We are using acoustic recordings to examine three local sites for their use by singing insects. Acoustic recordings collected during …
352— Investigating The Function Of Mhc Class I In Xenopus Laevis Tadpoles, Stephanie Alvarez Merlos, Annika Mounts
352— Investigating The Function Of Mhc Class I In Xenopus Laevis Tadpoles, Stephanie Alvarez Merlos, Annika Mounts
GREAT Day Posters
Xenopus laevis, is an excellent model organism for transgenesis and immunological research due to their large eggs and the similarities between mammalian and amphibian immune systems. MHC Class I is found on nearly all cells and educates T cells to recognize between self and non-self which is an essential immune system function. However, tadpoles don’t have detectable MHC Class I expression while adult frogs do. Despite this tadpoles are still immunocompetent; thus the role of MHC Class I in tadpoles is unknown. To investigate MHC Class I function we inactivated the corresponding gene in Xenopus laevis using CRISPR/Cas9. The …
006— Pretreatment And Fiber Content Analysis Of Cannabis Sativa, Dina Bu, Jessica Roggie, Sarah Schmidlin, Barnabas Gikonyo
006— Pretreatment And Fiber Content Analysis Of Cannabis Sativa, Dina Bu, Jessica Roggie, Sarah Schmidlin, Barnabas Gikonyo
GREAT Day Posters
Cannabis sativa commonly known as hemp is one of the fastest-growing plants whose refined products have immense commercial value. Various products include refined hemp such as: biofuels, biodegradable plastics, textiles, dietary supplements, paper, clothing, and much more. Hemp fibers are also used in construction and manufacturing applications by strengthening their composite products. Hemp is a high yielding, sustainable, and environmentally friendly crop due to its various qualities, and has the potential to yield valuable raw materials for a great number of applications. Our research evaluates the pretreatment of hemp as well as the comparative analysis of the fiber content thereof. …
381— Virtual Community Outreach For Elementary School Children In R-Kids After-School Program: A Novel Way To Teach Students About Neuroscience, Lucia Verrelli, Natasha Cotrupi, Julia Hoyt, Daniella Quiroz, Terence Bazzett
381— Virtual Community Outreach For Elementary School Children In R-Kids After-School Program: A Novel Way To Teach Students About Neuroscience, Lucia Verrelli, Natasha Cotrupi, Julia Hoyt, Daniella Quiroz, Terence Bazzett
GREAT Day Posters
Applications in Neuroscience (NEUR215) offers an opportunity for community outreach within the Neuroscience major. Students enrolled in NEUR215 create neuroscience-based activities designed to foster an excitement for science and to promote higher education in elementary school students recruited through the R-Kids after-school enrichment program. Four one-hour live sessions were held via Zoom with 2-5 R-Kids participants attending each session. Due to the COVID-19 pandemic, all lessons were transitioned virtually during the fall 2020 semester, and effective teaching strategies in a virtual environment were explored. The results of this investigation showed that online learning can be both fun and effective. Inviting …
022— Examining P27 Expression And Quiescence In Clobetasol-Exposed Umscv-4 Vulvar Cancer Cells, Nina Mustico, Vincent Scalcione, Jani E. Lewis
022— Examining P27 Expression And Quiescence In Clobetasol-Exposed Umscv-4 Vulvar Cancer Cells, Nina Mustico, Vincent Scalcione, Jani E. Lewis
GREAT Day Posters
Vulvar cancer is rare, mostly afflicting women aged 60 and older [1]. The cancer is often preceded by a common vulvar rash, lichen sclerosus, that is usually treated with the ultra-potent corticosteroid, clobetasol propionate. This treatment may, in turn, be associated with vulvar carcinogenesis. Our previous findings suggest that clobetasol is causing UMSCV-4 vulvar carcinoma cells to enter a state of quiescence. Quiescence is temporary removal from the cell cycle and can be thought of as a dormant state in which cells are not actively dividing [2]. There is growing evidence suggesting that quiescence may play a role in allowing …