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Iread: A Tool For Intron Retention Detection From Rna-Seq Data., Hong-Dong Li, Cory C Funk, Nathan D Price

Articles, Abstracts, and Reports

BACKGROUND: Intron retention (IR) has been traditionally overlooked as 'noise' and received negligible attention in the field of gene expression analysis. In recent years, IR has become an emerging field for interrogating transcriptomes because it has been recognized to carry out important biological functions such as gene expression regulation and it has been found to be associated with complex diseases such as cancers. However, methods for detecting IR today are limited. Thus, there is a need to develop novel methods to improve IR detection.

RESULTS: Here we present iREAD (intron REtention Analysis and Detector), a tool to detect IR events …