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Articles 1 - 30 of 43
Full-Text Articles in Life Sciences
Proteomic Analysis Of The Acidocalcisome, An Organelle Conserved From Bacteria To Human Cells, Guozhong Huang, Paul N. Ulrich, Melissa Storey, Darryl Johnson, Julie Tischer, Javier A. Tovar, Silvia N. J. Moreno, Ron Orlando, Robert Docampo
Proteomic Analysis Of The Acidocalcisome, An Organelle Conserved From Bacteria To Human Cells, Guozhong Huang, Paul N. Ulrich, Melissa Storey, Darryl Johnson, Julie Tischer, Javier A. Tovar, Silvia N. J. Moreno, Ron Orlando, Robert Docampo
Biology Faculty Publications
Acidocalcisomes are acidic organelles present in a diverse range of organisms from bacteria to human cells. In this study acidocalcisomes were purified from the model organism Trypanosoma brucei, and their protein composition was determined by mass spectrometry. The results, along with those that we previously reported, show that acidocalcisomes are rich in pumps and transporters, involved in phosphate and cation homeostasis, and calcium signaling. We validated the acidocalcisome localization of seven new, putative, acidocalcisome proteins (phosphate transporter, vacuolar H+-ATPase subunits a and d, vacuolar iron transporter, zinc transporter, polyamine transporter, and acid phosphatase), confirmed the presence of six previously characterized …
Recombinant Influenza Virus Carrying The Conserved Domain Of Respiratory Syncytial Virus (Rsv) G Protein Confers Protection Against Rsv Without Inflammatory Disease, Yu-Na Lee, Hye Suk Hwang, Min-Chul Kim, Young-Tae Lee, Min-Kyoung Cho, Young-Man Kwon, Jong Seok Lee, Richard K. Plemper, Sang-Moo Kang
Recombinant Influenza Virus Carrying The Conserved Domain Of Respiratory Syncytial Virus (Rsv) G Protein Confers Protection Against Rsv Without Inflammatory Disease, Yu-Na Lee, Hye Suk Hwang, Min-Chul Kim, Young-Tae Lee, Min-Kyoung Cho, Young-Man Kwon, Jong Seok Lee, Richard K. Plemper, Sang-Moo Kang
Biology Faculty Publications
Respiratory syncytial virus (RSV) is one of the most important causes for viral lower respiratory tract disease in humans. There is no licensed RSV vaccine. Here, we generated recombinant influenza viruses (PR8/RSV. HA-G) carrying the chimeric constructs of hemagglutinin (HA) and central conserved-domains of the RSV G protein. PR8/RSV.HA-G virus showed lower pathogenicity without compromising immunogenicity in mice. Single intranasal inoculation of mice with PR8/RSV.HA-G induced IgG2a isotype dominant antibodies and RSV neutralizing activity. Mice with single intranasal inoculation of PR8/RSV.HA-G were protected against RSV infection as evidenced by significant reduction of lung viral loads to a detection limit upon …
Hes-Mediated Repression Of Pten In Caenorhabditis Elegans, Han Ting Chou, Raymarie Gomez Vazquez, Kun Wang, Richard Campbell, Gaolin Zheng Milledge, Walter W. Walthall, Casonya Matese Johnson
Hes-Mediated Repression Of Pten In Caenorhabditis Elegans, Han Ting Chou, Raymarie Gomez Vazquez, Kun Wang, Richard Campbell, Gaolin Zheng Milledge, Walter W. Walthall, Casonya Matese Johnson
Biology Faculty Publications
The Hairy/Enhancer-of-Split (HES) group of transcription factors controls embryonic development, often by acting downstream of the Notch signaling pathway; however, little is known about postembryonic roles of these proteins. In Caenorhabditis elegans, the six proteins that make up the REF-1 family are considered to be HES orthologs that act in both Notch dependent and Notch-independent pathways to regulate embryonic events. To further our understanding of how the REF-1 family works to coordinate post-embryonic cellular events, we performed a functional characterization of the REF-1 family member, HLH-25. We show that, after embryogenesis, hlh-25 expression persists throughout every developmental stage, including dauer, …
Cyclodextrin Complexes Of Reduced Bromonoscapine In Guar Gum Microspheres Enhance Colonic Drug Delivery, Jitender Madan, Sushma R. Gundala, Bharat Baruah, Mulpuri Nagaraju, Clayton Yates, Timothy Turner, Vijay Rangari, Donald Hamelberg, Michelle D. Reid, Ritu Aneja
Cyclodextrin Complexes Of Reduced Bromonoscapine In Guar Gum Microspheres Enhance Colonic Drug Delivery, Jitender Madan, Sushma R. Gundala, Bharat Baruah, Mulpuri Nagaraju, Clayton Yates, Timothy Turner, Vijay Rangari, Donald Hamelberg, Michelle D. Reid, Ritu Aneja
Biology Faculty Publications
Here, we report improved solubility and enhanced colonic delivery of reduced bromonoscapine (Red-Br-Nos), a cyclic ether brominated analogue of noscapine, upon encapsulation of its cyclodextrin (CD) complexes in bioresponsive guar gum microspheres (GGM). Phase−solubility analysis suggested that Red-Br-Nos complexed with β-CD and methyl-β-CD in a 1:1 stoichiometry, with a stability constant (Kc) of 2.29 × 103 M−1 and 4.27 × 103 M−1. Fourier transforms infrared spectroscopy indicated entrance of an O−CH2 or OCH3−C6H4−OCH3 moiety of Red-Br-Nos in the β-CD or methyl-β- CD cavity. Furthermore, the cage complex of Red-Br-Nos with β-CD and methyl-β-CD was validated by several spectral techniques. Rotating …
Cell-Type Specific Transcriptomic Profiling To Dissect Mechanisms Of Differential Dendritogenesis, Surajit Bhattacharya, Eswar Prasad R. Iyer, Srividya Chandramouli Iyer, Daniel N. Cox
Cell-Type Specific Transcriptomic Profiling To Dissect Mechanisms Of Differential Dendritogenesis, Surajit Bhattacharya, Eswar Prasad R. Iyer, Srividya Chandramouli Iyer, Daniel N. Cox
Neuroscience Institute Faculty Publications
The establishment, maintenance and modulation of cell-type specific neural architectures are critically important to the formation of functional neural networks. At the neuroanatomical level, differential patterns of dendritic arborization directly impact neural function and connectivity, however the molecular mechanisms underlying the specification of distinct dendrite morphologies remain incompletely understood. To address this question, we analyzed global gene expression from purified populations of wild-type class I and class IV Drosophila melanogaster dendritic arborization (da) sensory neurons compared to wild-type whole larval RNA using oligo DNA microarray expression profiling. Herein we present detailed experimental methods and bioinformatic anal- yses to correspond with …
Tlr5-Mediated Sensing Of Gut Microbiota Is Necessary For Antibody Responses To Seasonal Influenza Vaccination, Jason Z. Oh, Rajesh Ravidran, Benoit Chassaing, Frederic A. Carvalho, Mohan S. Madur, Maureen Bower, Paul Hakimpour, Kiran P. Gill, Helder I. Nakaya, Felix Yarovinsky, R. Balfour Sartor, Andrew T. Gewirtz, Bali Pulendran
Tlr5-Mediated Sensing Of Gut Microbiota Is Necessary For Antibody Responses To Seasonal Influenza Vaccination, Jason Z. Oh, Rajesh Ravidran, Benoit Chassaing, Frederic A. Carvalho, Mohan S. Madur, Maureen Bower, Paul Hakimpour, Kiran P. Gill, Helder I. Nakaya, Felix Yarovinsky, R. Balfour Sartor, Andrew T. Gewirtz, Bali Pulendran
Biology Faculty Publications
No abstract provided.
Modulation Of Cytochrome P450 Metabolism And Transport Across Intestinal Epithelial Barrier By Ginger Biophenolics, Rao Mukkavilli, Sushma R. Gundala, Chunhua Yang, Shashikiran Donthamsetty, Guilherme Cantuaria, Gajanan R. Jadhav, Subrahmanyam Vangala, Michelle D. Reid, Ritu Aneja
Modulation Of Cytochrome P450 Metabolism And Transport Across Intestinal Epithelial Barrier By Ginger Biophenolics, Rao Mukkavilli, Sushma R. Gundala, Chunhua Yang, Shashikiran Donthamsetty, Guilherme Cantuaria, Gajanan R. Jadhav, Subrahmanyam Vangala, Michelle D. Reid, Ritu Aneja
Biology Faculty Publications
Natural and complementary therapies in conjunction with mainstream cancer care are steadily gaining popularity. Ginger extract (GE) confers significant health-promoting benefits owing to complex additive and/or synergistic interactions between its bioactive constituents. Recently, we showed that preservation of natural ‘‘milieu’’ confers superior anticancer activity on GE over its constituent phytochemicals, 6-gingerol (6G), 8-gingerol (8G), 10-gingerol (10G) and 6-shogaol (6S), through enterohepatic recirculation. Here we further evaluate and compare the effects of GE and its major bioactive constituents on cytochrome P450 (CYP) enzyme activity in human liver microsomes by monitoring metabolites of CYPspecific substrates using LC/MS/MS detection methods. Our data demonstrate …
Deep Learning For Neuroimaging: A Validation Study, Sergey M. Plis, Devon R. Hjelm, Ruslan Salakhutdinov, Elena A. Allen, Henry J. Bockholt, Jeffrey D. Long, Hans J. Johnson, Jane S. Paulsen, Jessica A. Turner, Vince D. Calhoun
Deep Learning For Neuroimaging: A Validation Study, Sergey M. Plis, Devon R. Hjelm, Ruslan Salakhutdinov, Elena A. Allen, Henry J. Bockholt, Jeffrey D. Long, Hans J. Johnson, Jane S. Paulsen, Jessica A. Turner, Vince D. Calhoun
Neuroscience Institute Faculty Publications
Deep learning methods have recently made notable advances in the tasks of classification and representation learning. These tasks are important for brain imaging and neuroscience discovery, making the methods attractive for porting to a neuroimager’s toolbox. Success of these methods is, in part, explained by the flexibility of deep learning models. However, this flexibility makes the process of porting to new areas a difficult parameter optimization problem. In this work we demonstrate our results (and feasible parameter ranges) in application of deep learning methods to structural and functional brain imaging data. These methods include deep belief networks and their building …
Each Of The Eight Simian Hemorrhagic Fever Virus Minor Structural Proteins Is Functionally Important, Heather A. Vatter, Han Di, Eric F. Donaldson, Ralph S. Baric, Margo A. Brinton
Each Of The Eight Simian Hemorrhagic Fever Virus Minor Structural Proteins Is Functionally Important, Heather A. Vatter, Han Di, Eric F. Donaldson, Ralph S. Baric, Margo A. Brinton
Biology Faculty Publications
The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication characteristics similar to those of the parental virus. A subgenomic mRNA was identified for the SHFV ORF previously identified as 2b. As an initial means of analyzing the functional relevance of each of the SHFV minor structural proteins, a set of mutant infectious clones was generated, each with the start codon of one …
Interdisciplinary Perspectives On The Development, Integration, And Application Of Cognitive Ontologies, Janna Hastings, Gwen A. Frishkoff, Barry Smith, Mark Jensen, Russell A. Poldrack, Jane Lomax, Anita Bandrowski, Fahim Imam, Jessica Turner, Maryann E. Martone
Interdisciplinary Perspectives On The Development, Integration, And Application Of Cognitive Ontologies, Janna Hastings, Gwen A. Frishkoff, Barry Smith, Mark Jensen, Russell A. Poldrack, Jane Lomax, Anita Bandrowski, Fahim Imam, Jessica Turner, Maryann E. Martone
Neuroscience Institute Faculty Publications
We discuss recent progress in the development of cognitive ontologies and summarize three challenges in the coordinated development and application of these resources. Challenge 1 is to adopt a standardized definition for cognitive processes. We describe three possibilities and recommend one that is consistent with the standard view in cognitive and biomedical sciences. Challenge 2 is harmonization. Gaps and conflicts in representation must be resolved so that these resources can be combined for mark-up and interpretation of multi-modal data. Finally, Challenge 3 is to test the utility of these resources for large- scale annotation of data, search and query, and …
Hidden Synaptic Differences In A Neural Circuit Underlie Differential Behavioral Susceptibility To A Neural Injury, Akira Sakurai, Arianna Tamvacakis, Paul Katz
Hidden Synaptic Differences In A Neural Circuit Underlie Differential Behavioral Susceptibility To A Neural Injury, Akira Sakurai, Arianna Tamvacakis, Paul Katz
Neuroscience Institute Faculty Publications
Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animals within the neural circuit underlying swimming behavior had no behavioral relevance under normal conditions but caused differential vulnerability of the behavior to a particular brain lesion. The extent of motor impairment correlated with the site of spike initiation in a specific neuron in the neural circuit, which was determined by the strength of an …
Hidden Synaptic Differences In A Neural Circuit Underlie Differential Behavioral Susceptibility To A Neural Injury, Akira Sakurai, Arianna Tamvacakis, Paul S. Katz
Hidden Synaptic Differences In A Neural Circuit Underlie Differential Behavioral Susceptibility To A Neural Injury, Akira Sakurai, Arianna Tamvacakis, Paul S. Katz
Neuroscience Institute Faculty Publications
Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animals within the neural circuit underlying swimming behavior had no behavioral relevance under normal conditions but caused differential vulnerability of the behavior to a particular brain lesion. The extent of motor impairment correlated with the site of spike initiation in a specific neuron in the neural circuit, which was determined by the strength of an …
Kifci, A Novel Putative Prognostic Biomarker For Ovarian Adenocarcinomas: Delineating Protein Interaction Networks And Signaling Circuitries, Shrikant Pawar, Shashikiran Donthamsetty, Vaishali Pannu, Padmashree Rida, Angela Ogden, Nathan Bowen, Remus Osan, Guilherme Cantuaria, Ritu Aneja
Kifci, A Novel Putative Prognostic Biomarker For Ovarian Adenocarcinomas: Delineating Protein Interaction Networks And Signaling Circuitries, Shrikant Pawar, Shashikiran Donthamsetty, Vaishali Pannu, Padmashree Rida, Angela Ogden, Nathan Bowen, Remus Osan, Guilherme Cantuaria, Ritu Aneja
Biology Faculty Publications
Background: Amplified centrosomes in cancers are recently garnering a lot of attention as an emerging hub of diagnostic, prognostic and therapeutic targets. Ovarian adenocarcinomas commonly harbor supernumerary centrosomes that drive chromosomal instability. A centrosome clustering molecule, KIFC1, is indispensable for the viability of extra centrosome-bearing cancer cells, and may underlie progression of ovarian cancers.
Methods: Centrosome amplification in low- and high- grade serous ovarian adenocarcinomas was quantitated employing confocal imaging. KIFC1 expression was analyzed in ovarian tumors using publically-available databases. Associated grade, stage and clinical information from these databases were plotted for KIFC1 gene expression values. Furthermore, interactions and functional …
Cephalopod Ink: Production, Chemistry, Functions And Applications, Charles D. Derby
Cephalopod Ink: Production, Chemistry, Functions And Applications, Charles D. Derby
Biology Faculty Publications
One of the most distinctive and defining features of coleoid cephalopods—squid, cuttlefish and octopus—is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalopod ink. Topics include: (1) the production of ink, including the functional organization of the ink sac and funnel organ that produce it; (2) the chemical components of ink, with a focus on the best known of these—melanin and the biochemical pathways involved in its production; (3) the neuroecology of the use of ink …
Sharing Privacy-Sensitive Access To Neuroimaging And Genetics Data: A Review And Preliminary Validation, Anand D. Sarwate, Sergey M. Plis, Jessica A. Turner, Mohammad R. Arbabshirani, Vince D. Calhoun
Sharing Privacy-Sensitive Access To Neuroimaging And Genetics Data: A Review And Preliminary Validation, Anand D. Sarwate, Sergey M. Plis, Jessica A. Turner, Mohammad R. Arbabshirani, Vince D. Calhoun
Neuroscience Institute Faculty Publications
The growth of data sharing initiatives for neuroimaging and genomics represents an exciting opportunity to confront the “small N” problem that plagues contemporary neuroimaging studies while further understanding the role genetic markers play in the function of the brain. When it is possible, open data sharing provides the most benefits. However, some data cannot be shared at all due to privacy concerns and/or risk of re-identification. Sharing other data sets is hampered by the proliferation of complex data use agreements (DUAs) which preclude truly automated data mining. These DUAs arise because of concerns about the privacy and confidentiality for subjects; …
Sharing Privacy-Sensitive Access To Neuroimaging And Genetics Data: A Review And Preliminary Validation, Anand D. Sarwate, Sergey M. Plis, Jessica Turner, Mohammad R. Arbabshirani, Vince D. Calhoun
Sharing Privacy-Sensitive Access To Neuroimaging And Genetics Data: A Review And Preliminary Validation, Anand D. Sarwate, Sergey M. Plis, Jessica Turner, Mohammad R. Arbabshirani, Vince D. Calhoun
Neuroscience Institute Faculty Publications
The growth of data sharing initiatives for neuroimaging and genomics represents an exciting opportunity to confront the “small N” problem that plagues contemporary neuroimaging studies while further understanding the role genetic markers play in the function of the brain. When it is possible, open data sharing provides the most benefits. However, some data cannot be shared at all due to privacy concerns and/or risk of re-identification. Sharing other data sets is hampered by the proliferation of complex data use agreements (DUAs) which preclude truly automated data mining. These DUAs arise because of concerns about the privacy and confidentiality for subjects; …
Key Bifurcations Of Bursting Polyrhythms In 3-Cell Central Pattern Generators, Jeremy Wojcik, Justus Schwabedal, Robert Clewley, Andrey L. Shilnikov
Key Bifurcations Of Bursting Polyrhythms In 3-Cell Central Pattern Generators, Jeremy Wojcik, Justus Schwabedal, Robert Clewley, Andrey L. Shilnikov
Neuroscience Institute Faculty Publications
We identify and describe the key qualitative rhythmic states in various 3-cell network motifs of a multifunctional central pattern generator (CPG). Such CPGs are neural microcircuits of cells whose synergetic interactions produce multiple states with distinct phase-locked patterns of bursting activity. To study biologically plausible CPG models, we develop a suite of computational tools that reduce the problem of stability and existence of rhythmic patterns in networks to the bifurcation analysis of fixed points and invariant curves of a Poincare´ return maps for phase lags between cells. We explore different functional possibilities for motifs involving symmetry breaking and heterogeneity. This …
Pro-Inflammatory Mediation Of Myoblast Proliferation, Jeffrey Scott Otis, Sarah Niccoli, Nicole Hawdon, Jessica L. Sarvas, Melinda A. Frye, Adam J. Chicco, Simon J. Lees
Pro-Inflammatory Mediation Of Myoblast Proliferation, Jeffrey Scott Otis, Sarah Niccoli, Nicole Hawdon, Jessica L. Sarvas, Melinda A. Frye, Adam J. Chicco, Simon J. Lees
Kinesiology Faculty Publications
Skeletal muscle satellite cell function is largely dictated by the surrounding environment following injury. Immune cell infiltration dominates the extracellular space in the injured area, resulting in increased cytokine concentrations. While increased pro-inflammatory cytokine expression has been previously established in the first 3 days following injury, less is known about the time course of cytokine expression and the specific mechanisms of cytokine induced myoblast function. Therefore, the expression of IL-1b and IL-6 at several time points following injury, and their effects on myoblast proliferation, were examined. In order to do this, skeletal muscle was injured using barium chloride in mice …
The Drrab System Of Streptomyces Peucetius Is A Multi-Drug Transporter Of Broad Substrate Specificity, Wen Li, Madhu Sharma, Parjit Kaur
The Drrab System Of Streptomyces Peucetius Is A Multi-Drug Transporter Of Broad Substrate Specificity, Wen Li, Madhu Sharma, Parjit Kaur
Biology Faculty Publications
The soil bacterium Streptomyces peucetius produces two widely used anticancer antibiotics doxorubicin and daunorubicin. Present within the biosynthesis gene cluster in S. peucetius is the drrAB operon which codes for a dedicated ABC-type transporter for the export of these two closely related antibiotics. Because of its dedicated nature, the DrrAB system is believed to belong to the category of single-drug transporters. However, whether it also contains specificity for other known substrates of multidrug transporters has never been tested. In this study, we demonstrate under both in vivo and in vitro conditions that the DrrAB system can transport not only doxorubicin …
Intestinal Cgi-58 Deficiency Reduces Postprandial Lipid Absorption, Ping Xie, Feng Guo, Yinyan Ma, Hongling Xhu, Freddy Wang, Bingzhong Xue, Hang Shi, Jian Yang, Liqing Yu
Intestinal Cgi-58 Deficiency Reduces Postprandial Lipid Absorption, Ping Xie, Feng Guo, Yinyan Ma, Hongling Xhu, Freddy Wang, Bingzhong Xue, Hang Shi, Jian Yang, Liqing Yu
Biology Faculty Publications
Comparative Gene Identification-58 (CGI-58), a lipid droplet (LD)-associated protein, promotes intracellular triglyceride (TG) hydrolysis in vitro. Mutations in human CGI-58 cause TG accumulation in numerous tissues including intestine. Enterocytes are thought not to store TG-rich LDs, but a fatty meal does induce temporary cytosolic accumulation of LDs. Accumulated LDs are eventually cleared out, implying existence of TG hydrolytic machinery in enterocytes. However, identities of proteins responsible for LD-TG hydrolysis remain unknown. Here we report that intestine-specific inactivation of CGI-58 in mice significantly reduces postprandial plasma TG concentrations and intestinal TG hydrolase activity, which is associated with a 4-fold increase in …
Sexually Dimorphic Role For Vasopressin In The Development Of Social Play, Matthew J. Paul, Joseph I. Terranova, Clemens K. Probst, Elaine K. Murray, Nafissa I. Ismail, Geert De Vries
Sexually Dimorphic Role For Vasopressin In The Development Of Social Play, Matthew J. Paul, Joseph I. Terranova, Clemens K. Probst, Elaine K. Murray, Nafissa I. Ismail, Geert De Vries
Neuroscience Institute Faculty Publications
Despite the well-established role of arginine vasopressin (AVP) in adult social behavior, its role in social development is relatively unexplored. In this paper, we focus on the most prominent social behavior of juvenile rats, social play. Previous pharmacological experiments in our laboratory suggested that AVP regulates play in a sex- and brain region-specific manner in juvenile rats. Here we investigate the role of specific AVP systems in the emergence of social play. We first characterize the development of play in male and female Wistar rats and then ask whether the development of AVP mRNA expression correlates with the emergence of …
Colonic Mirna Expression/Secretion, Regulated By Intestinal Epithelial Pept1, Plays An Important Role In Cell-To-Cell Communication During Colitis, Saravanan Ayyadurai, Moiz A. Charania, Bo Xiao, Emilie Viennois, Yuchen Zhang, Didieer Merlin
Colonic Mirna Expression/Secretion, Regulated By Intestinal Epithelial Pept1, Plays An Important Role In Cell-To-Cell Communication During Colitis, Saravanan Ayyadurai, Moiz A. Charania, Bo Xiao, Emilie Viennois, Yuchen Zhang, Didieer Merlin
Biology Faculty Publications
PepT1 is a member of the proton-oligopeptide cotransporter family SLC15, which mediates the transport of di/tripeptides from intestinal lumen into epithelial cells. MicroRNAs (miRNAs), a small noncoding RNAs (21–23 nucleotides), posttranscriptionally regulate gene expression by binding to the 39-untranslated regions (UTRs) of their target mRNAs. Although the role of most miRNAs remains elusive, they have been implicated in vital cellular functions such as intestinal epithelial cells differentiation, proliferation, and apoptosis. In the present study, we investigated the effect of intestinal epithelial PepT1 expression on microRNA (miRNA) expression/secretion in the colons of control mice and in mice with experimentally induced colonic …
A Content Analysis Of The European Sport Management Quarterly And Its Predecessor The European Journal For Sport Management: 1984-2012, Brenda Pitts, Karen Danylchuk, Jerome Quarterman
A Content Analysis Of The European Sport Management Quarterly And Its Predecessor The European Journal For Sport Management: 1984-2012, Brenda Pitts, Karen Danylchuk, Jerome Quarterman
Kinesiology Faculty Publications
A profession must be built upon a sound body of knowledge in order for its professional status to be recognized and considered credible by society (Zeigler, 1987). The body of literature should also reflect and define the field (Fielding, Pitts, & Miller, 1991). To that end, examining the state of a body of literature is essential as the findings can reveal such significant information as content, trends, author collaboration, and topical gaps and disparities. The purpose of this study was to examine the European Sport Management Quarterly and its predecessor the European Journal for Sport Management. A content analysis of …
Exploring The Work–Life Balance Of Intercollegiate Athletic Graduate Assistants: A Preliminary Study Of Work–Extracurricular Conflict, Shaina M. Ervin, Beth Cianfrone
Exploring The Work–Life Balance Of Intercollegiate Athletic Graduate Assistants: A Preliminary Study Of Work–Extracurricular Conflict, Shaina M. Ervin, Beth Cianfrone
Kinesiology Faculty Publications
Intercollegiate athletics are a popular and competitive field, with employees drawn to a dynamic, yet untraditional work environment with varying work hours. The struggle of achieving work-life balance has received considerable study in sport, as employees often find a conflict in balancing their job and other life responsibilities, such as family (work-family conflict). This chapter introduces a new area of potential employee internal conflict, work-extracurricular conflict, which encompasses everything outside of work and family, such spiritual, hobbies, exercise/health, school, and social activities. This conflict may be especially relevant to a segment of the industry which is rarely studied, intercollegiate athletic …
Civic Paternalism In Political Policymaking: The Justification For No-Vote Stadium Subsidies, Timothy Kellison, Michael Mondello
Civic Paternalism In Political Policymaking: The Justification For No-Vote Stadium Subsidies, Timothy Kellison, Michael Mondello
Kinesiology Faculty Publications
Direct democracy practices such as initiatives and referenda are increasingly ignored or circumvented by political leaders who allocate subsidies toward new professional sport stadium developments. In a democracy, such a means of governing may be problematic if the outcome is unreflective of the public will. The existing literature makes several theoretical connections for this line of political decision-making, including urban growth machines and trustee–delegate representation. In this paper, these concepts are integrated with empirical evidence to support the conceptualization of civic paternalism, a term that provides partial description of the political decision-making process. Civic paternalists justify their decisions by arguing …
Dopaminergic Tone Persistently Regulates Voltage-Gated Ion Current Densities Through The D1r-Pka Axis, Rna Polymerase Ii Transcription, Rnai, Mtorc1, And Translation, Wulf-Dieter C. Krenz, Anna R. Parker, Edmund William Rodgers, Deborah J. Baro
Dopaminergic Tone Persistently Regulates Voltage-Gated Ion Current Densities Through The D1r-Pka Axis, Rna Polymerase Ii Transcription, Rnai, Mtorc1, And Translation, Wulf-Dieter C. Krenz, Anna R. Parker, Edmund William Rodgers, Deborah J. Baro
Biology Faculty Publications
Long-term intrinsic and synaptic plasticity must be coordinated to ensure stability and flexibility in neuronal circuits. Coordination might be achieved through shared transduction components. Dopamine (DA) is a well-established participant in many forms of long-term synaptic plasticity. Recent work indicates that DA is also involved in both activity-dependent and -independent forms of long-term intrinsic plasticity. We previously examined DA-enabled long-term intrinsic plasticity in a single identified neuron. The lateral pyloric (LP) neuron is a component of the pyloric network in the crustacean stomatogastric nervous system (STNS). LP expresses type 1 DA receptors (D1Rs). A 1 h bath application of 5 …
Dopamine Signaling In C. Elegans Is Mediated In Part By Hlh-17-Dependent Regulation Of Extracellular Dopamine Levels, Chaquettea M. Felton, Casonya Matese Johnson
Dopamine Signaling In C. Elegans Is Mediated In Part By Hlh-17-Dependent Regulation Of Extracellular Dopamine Levels, Chaquettea M. Felton, Casonya Matese Johnson
Biology Faculty Publications
In Caenorhabditis elegans, the dopamine transporter DAT-1 regulates synaptic dopamine (DA) signaling by controlling extracellular DA levels. In dat-1(ok157) animals, DA is not taken back up presynaptically but instead reaches extrasynpatic sites, where it activates the dopamine receptor DOP-3 on choligeneric motor neurons and causes animals to become paralyzed in water. This phenotype is called swimming-induced paralysis (SWIP) and is dependent on dat-1 and dop-3. Upstream regulators of dat-1 and dop-3 have yet to be described in C. elegans. In our previous studies, we defined a role for HLH-17 during dopamine response through its regulation of the dopamine receptors. Here …
New Vaccines Against Influenza Virus, Young-Tae Lee, Ki-Hye Kim, Eun-Ju Ko, Yu-Na Lee, Min-Chul Kim, Young-Man Kwon, Yinghua Tang, Min-Kyoung Cho, Youn-Jeong Lee, Sang-Moon Kang
New Vaccines Against Influenza Virus, Young-Tae Lee, Ki-Hye Kim, Eun-Ju Ko, Yu-Na Lee, Min-Chul Kim, Young-Man Kwon, Yinghua Tang, Min-Kyoung Cho, Youn-Jeong Lee, Sang-Moon Kang
Biology Faculty Publications
Vaccination is one of the most effective and cost-benefit interventions that prevent the mortality and reduce morbidity from infectious pathogens. However, the licensed influenza vaccine induces strain-specific immunity and must be updated annually based on predicted strains that will circulate in the upcoming season. Influenza virus still causes significant health problems worldwide due to the low vaccine efficacy from unexpected outbreaks of next epidemic strains or the emergence of pandemic viruses. Current influenza vaccines are based on immunity to the hemagglutinin antigen that is highly variable among different influenza viruses circulating in humans and animals. Several scientific advances have been …
Quantitative Multi-Parametric Evaluation Of Centrosome Declustering Drugs: Centrosome Amplification, Mitotic Phenotype, Cell Cycle And Death, Vaishali Pannu, Ritu Aneja, Angela Ogden, A. Cheng, Pcg Rida, R. Osan, Robert Clewley
Quantitative Multi-Parametric Evaluation Of Centrosome Declustering Drugs: Centrosome Amplification, Mitotic Phenotype, Cell Cycle And Death, Vaishali Pannu, Ritu Aneja, Angela Ogden, A. Cheng, Pcg Rida, R. Osan, Robert Clewley
Biology Faculty Publications
Unlike normal cells, cancer cells contain amplified centrosomes and rely on centrosome clustering mechanisms to form a pseudobipolar spindle that circumvents potentially fatal spindle multipolarity (MP). Centrosome clustering also promotes lowgrade chromosome missegregation, which can drive malignant transformation and tumor progression. Putative ‘centrosome declustering drugs’ represent a cancer cell-specific class of chemotherapeutics that produces a common phenotype of centrosome declustering and spindle MP. However, differences between individual agents in terms of efficacy and phenotypic nuances remain unexplored. Herein, we have developed a conceptual framework for the quantitative evaluation of centrosome declustering drugs by investigating their impact on centrosomes, clustering, spindle …
Macrophage Cgi-58 Deficiency Activates Ros-Inflammasome Pathway To Promote Insulin Resistance In Mice, Hongming Miao, Juanjuan Ou, Yinyan Ma, Feng Guo, Zhenggang Yang, Melvin Wiggins, Chaohong Liu, Wenxia Song, Xianlin Han, Miao Wang, Qiang Cao, Bik-Ho Florence Chung, Dan Yang, Houjie Liang, Bingzhong Xue, Hang Shi, Lixia Gan, Liqing Yu
Macrophage Cgi-58 Deficiency Activates Ros-Inflammasome Pathway To Promote Insulin Resistance In Mice, Hongming Miao, Juanjuan Ou, Yinyan Ma, Feng Guo, Zhenggang Yang, Melvin Wiggins, Chaohong Liu, Wenxia Song, Xianlin Han, Miao Wang, Qiang Cao, Bik-Ho Florence Chung, Dan Yang, Houjie Liang, Bingzhong Xue, Hang Shi, Lixia Gan, Liqing Yu
Biology Faculty Publications
No abstract provided.