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Full-Text Articles in Life Sciences
Histone Deacetylase 1 (Hdac1) Negatively Regulates Thermogenic Program In Brown Adipocytes Via Coordinated Regulation Of H3k27 Deacetylation And Methylation, Fenfen Li, Rui Wu, Xin Cui, Lin Zha, Liqing Yu, Hang Shi, Bingzhong Xue
Histone Deacetylase 1 (Hdac1) Negatively Regulates Thermogenic Program In Brown Adipocytes Via Coordinated Regulation Of H3k27 Deacetylation And Methylation, Fenfen Li, Rui Wu, Xin Cui, Lin Zha, Liqing Yu, Hang Shi, Bingzhong Xue
Biology Faculty Publications
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces adiposity and improves insulin sensitivity in obese mice. However, the precise mechanism is poorly understood. Here, we demonstrate that HDAC1 is a negative regulator of brown adipocyte thermogenic program. HDAC1 level is lower in mouse brown fat (BAT) than white fat, is suppressed in mouse BAT during cold exposure or β3-adrenergic stimulation, and is down-regulated during brown adipocyte differentiation. Remarkably, overexpressing HDAC1 profoundly blocks, whereas deleting HDAC1 significantly enhances β-adrenergic activation-induced BAT-specific gene expression in brown adipocytes. β-adrenergic activation in brown adipocytes results in a dissociation of HDAC1 from promoters …