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Full-Text Articles in Life Sciences
Characterizing Persistent Developmental Dyscalculia: A Cognitive Neuroscience Approach, Stephanie D. Bugden
Characterizing Persistent Developmental Dyscalculia: A Cognitive Neuroscience Approach, Stephanie D. Bugden
Electronic Thesis and Dissertation Repository
Developmental dyscalculia (DD) is a specific learning disorder of calculation abilities. In the present thesis I report a series behavioural and functional neuroimaging studies to further elucidate the core numerical deficits underlying DD. I recruited a sample of children with DD who demonstrated persistent impairments in arithmetic. In Chapter 2, to validate the selection criteria, I compared the performance of children with and without persistent DD on a test of numerical magnitude processing. The data showed that only children with persistent DD presented with deficits in numerical magnitude processing, while those with inconsistent DD perform at the level of age-matched …
Alcohol Use Disorders And An Fmri Stress Task: A Connectivity Analysis, Natasha E. Wright
Alcohol Use Disorders And An Fmri Stress Task: A Connectivity Analysis, Natasha E. Wright
Theses and Dissertations
Little research has been conducted on neuronal stress processing in individuals
with alcohol dependence (AD). The present study examined neural stress response in AD individuals compared to controls using an fMRI stress task, assessing amygdala
activation and its connectivity to the medial prefrontal cortex (mPFC). Further, the study
analyzed the impact of hormone levels and subjective stress on frontal-limbic
connectivity patterns.
Ten abstinent AD individuals and 11 controls were recruited. Subjects
participated in an fMRI stress task. A region of interest (amygdala) analysis was
conducted using area-under-the-curve. This activation was then examined in a whole brain functional connectivity analysis. Follow-up …
Pre-Stimulus Neural Activity Predicts Successful Encoding Of Inter-Item Associations, Richard J. Addante, Marianne De Chastelaine, Michael D. Rugg
Pre-Stimulus Neural Activity Predicts Successful Encoding Of Inter-Item Associations, Richard J. Addante, Marianne De Chastelaine, Michael D. Rugg
Psychology Faculty Publications
fMRI was employed to investigate the relationship between pre-stimulus neural activity and associative encoding of words and pictures in humans. While undergoing scanning, subjects studied randomly interleaved word or picture pairs. A pre-stimulus cue preceded the presentation of each study pair and signaled whether it would comprise words or pictures. Memory for the study pairs was later tested with an associative recognition test, which comprised word or picture pairs presented either in the same (intact) or a different (rearranged) pairing as at study, along with pairs of new items. The critical fMRI contrast was between study activity associated with pairs …
Mental Representations, Social Exclusion, And Neurobiological Processes In Borderline Personality Disorder: A Multi-Level Study, Jeffrey K. Erbe
Mental Representations, Social Exclusion, And Neurobiological Processes In Borderline Personality Disorder: A Multi-Level Study, Jeffrey K. Erbe
Dissertations, Theses, and Capstone Projects
Borderline Personality Disorder (BPD) is an ongoing public health crisis. Poor developmental quality of differentiation-relatedness of object representations and attachment insecurity have been clinically and empirically demonstrated as core patterns of intrapsychic and interpersonal dysfunction in this particular form of personality pathology. Differentiation-relatedness (D-R), which involves a complementary relationship between intrapsychic autonomy and interpersonal relatedness, has been shown to be a significant aspect of internal psychic experience that relates directly to external relationship patterns, including characteristic response to interpersonal interactions and has been a specific target for treatment of BPD. Specifically, individuals with BPD have shown lower developmental quality of …
Advances In Image Acquisition And Filtering For Mri Neuroimaging At 7 Tesla, Andrew T. Curtis
Advances In Image Acquisition And Filtering For Mri Neuroimaging At 7 Tesla, Andrew T. Curtis
Electronic Thesis and Dissertation Repository
Performing magnetic resonance imaging at high magnetic field strength promises many improvements over low fields that are of direct benefit in functional neuroimaging. This includes the possibility of improved signal-to-noise levels, and increased BOLD functional contrast and spatial specificity. However, human MRI at 7T and above suffers from unique engineering challenges that limit the achievable gains. In this thesis, three technological developments are introduced, all of which address separate issues associated with functional magnetic resonance neuroimaging at very high magnetic field strengths.
First, the image homogeneity problem is addressed by investigating methods of RF shimming — modifying the excitation portion …
Deep Learning For Neuroimaging: A Validation Study, Sergey M. Plis, Devon R. Hjelm, Ruslan Salakhutdinov, Elena A. Allen, Henry J. Bockholt, Jeffrey D. Long, Hans J. Johnson, Jane S. Paulsen, Jessica A. Turner, Vince D. Calhoun
Deep Learning For Neuroimaging: A Validation Study, Sergey M. Plis, Devon R. Hjelm, Ruslan Salakhutdinov, Elena A. Allen, Henry J. Bockholt, Jeffrey D. Long, Hans J. Johnson, Jane S. Paulsen, Jessica A. Turner, Vince D. Calhoun
Neuroscience Institute Faculty Publications
Deep learning methods have recently made notable advances in the tasks of classification and representation learning. These tasks are important for brain imaging and neuroscience discovery, making the methods attractive for porting to a neuroimager’s toolbox. Success of these methods is, in part, explained by the flexibility of deep learning models. However, this flexibility makes the process of porting to new areas a difficult parameter optimization problem. In this work we demonstrate our results (and feasible parameter ranges) in application of deep learning methods to structural and functional brain imaging data. These methods include deep belief networks and their building …
Functional Correlates Of Optic Flow Motion Processing In Parkinson's Disease, Deepti Putcha, Robert S. Ross, Maya L. Rosen, Daniel J. Norton, Alice Cronin-Golomb, David C. Somers, Chantal E. Stern
Functional Correlates Of Optic Flow Motion Processing In Parkinson's Disease, Deepti Putcha, Robert S. Ross, Maya L. Rosen, Daniel J. Norton, Alice Cronin-Golomb, David C. Somers, Chantal E. Stern
Neuroscience: Faculty Publications
The visual input created by the relative motion between an individual and the environment, also called optic flow, influences the sense of self-motion, postural orientation, veering of gait, and visuospatial cognition. An optic flow network comprising visual motion areas V6, V3A, and MT+, as well as visuo-vestibular areas including posterior insula vestibular cortex (PIVC) and cingulate sulcus visual area (CSv), has been described as uniquely selective for parsing egomotion depth cues in humans. Individuals with Parkinson's disease (PD) have known behavioral deficits in optic flow perception and visuospatial cognition compared to age- and education-matched control adults (MC). The present study …
Functional Mri Mapping Of Visual Function And Selective Attention For Performance Assessment And Presurgical Planning Using Conjunctive Visual Search, Jason G. Parker, Eric J. Zalusky, Cemil Kirbas
Functional Mri Mapping Of Visual Function And Selective Attention For Performance Assessment And Presurgical Planning Using Conjunctive Visual Search, Jason G. Parker, Eric J. Zalusky, Cemil Kirbas
Wright State Research Institute Publications
Background
Accurate mapping of visual function and selective attention using fMRI is important in the study of human performance as well as in presurgical treatment planning of lesions in or near visual centers of the brain. Conjunctive visual search (CVS) is a useful tool for mapping visual function during fMRI because of its greater activation extent compared with high-capacity parallel search processes.
Aims
The purpose of this work was to develop and evaluate a CVS that was capable of generating consistent activation in the basic and higher level visual areas of the brain by using a high number of distractors …
The Effect Of Age On Neural Processing Of Pleasant Soft Touch Stimuli, April C. May, Jennifer L. Stewart, Susan F. Tapert, Martin P. Paulus
The Effect Of Age On Neural Processing Of Pleasant Soft Touch Stimuli, April C. May, Jennifer L. Stewart, Susan F. Tapert, Martin P. Paulus
Publications and Research
Tactile interactions with our environment stimulate afferent fibers within the skin, which deliver information about sensations of pain, texture, itch and other feelings to the brain as a comprehensive sense of self. These tactile interactions can stimulate brain regions involved in interoception and reward processing. This study examined subjective, behavioral, and neural processing as a function of age during stimulation of A-beta (Aβ) and C tactile (CT) afferents using a soft brush stroke task. 16 adolescents (ages 15–17), 22 young adults (ages 20–28), and 20 mature adults (ages 29–55) underwent a simple continuous performance task while periodically anticipating and experiencing …
Winning And Losing: Differences In Reward And Punishment Sensitivity Between Smokers And Nonsmokers, Laura E. Martin, Lisa S. Cox, William M. Brooks, Cary R. Savage
Winning And Losing: Differences In Reward And Punishment Sensitivity Between Smokers And Nonsmokers, Laura E. Martin, Lisa S. Cox, William M. Brooks, Cary R. Savage
Center for Brain, Biology, and Behavior: Faculty and Staff Publications
Background: Smokers show increased brain activation in reward processing regions in response to smoking-related cues, yet few studies have examined secondary rewards not associated with smoking (i.e., money). Inconsistencies exist in the studies that do examine secondary rewards with some studies showing increased brain activation in reward processing brain regions, while others show decreased activation or no difference in activation between smokers and nonsmokers. Aims: The goal of the current study is to see if smokers process the evaluation and delivery of equally salient real world rewards similarly or differently than nonsmokers. Methods: The current study employed functional magnetic resonance …
The Neural Substrates Of Natural Reading: A Comparison Of Normal And Nonword Text Using Eyetracking And Fmri, W. Choi, Rutvik Desai, J. M. Henderson
The Neural Substrates Of Natural Reading: A Comparison Of Normal And Nonword Text Using Eyetracking And Fmri, W. Choi, Rutvik Desai, J. M. Henderson
Faculty Publications
Most previous studies investigating the neural correlates of reading have presented text using serial visual presentation (SVP), which may not fully reflect the underlying processes of natural reading. In the present study, eye movements and BOLD data were collected while subjects either read normal paragraphs naturally or moved their eyes through “paragraphs” of pseudo-text (pronounceable pseudowords or consonant letter strings) in two pseudo-reading conditions. Eye movement data established that subjects were reading and scanning the stimuli normally. A conjunction fMRI analysis across natural- and pseudo-reading showed that a common eye-movement network including frontal eye fields (FEF), supplementary eye fields (SEF), …