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Differentiation Of Complex Lipid Isomers By Radical-Directed Dissociation Mass Spectrometry, Huong Pham, Tony Ly, Adam Trevitt, Todd Mitchell, Stephen Blanksby
Differentiation Of Complex Lipid Isomers By Radical-Directed Dissociation Mass Spectrometry, Huong Pham, Tony Ly, Adam Trevitt, Todd Mitchell, Stephen Blanksby
Adam Trevitt
Contemporary lipidomics protocols are dependent on conventional tandem mass spectrometry for lipid identification. This approach is extremely powerful for determining lipid class and identifying the number of carbons and the degree of unsaturation of any acyl-chain substituents. Such analyses are however, blind to isomeric variants arising from different carbon−carbon bonding motifs within these chains including double bond position, chain branching, and cyclic structures. This limitation arises from the fact that conventional, low energy collision-induced dissociation of even-electron lipid ions does not give rise to product ions from intrachain fragmentation of the fatty acyl moieties. To overcome this limitation, we have …
Cyclic Versus Linear Isomers Produced By Reaction Of The Methylidyne Radical (Ch) With Small Unsaturated Hydrocarbons, Adam Trevitt, Talitha Selby, Luc Vereecken, Fabien Goulay, Giovanni Meloni, David Osborn, Craig Taatjes, Stephen Leone
Cyclic Versus Linear Isomers Produced By Reaction Of The Methylidyne Radical (Ch) With Small Unsaturated Hydrocarbons, Adam Trevitt, Talitha Selby, Luc Vereecken, Fabien Goulay, Giovanni Meloni, David Osborn, Craig Taatjes, Stephen Leone
Adam Trevitt
No abstract provided.