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Microbiology

2009

Articles 1 - 4 of 4

Full-Text Articles in Life Sciences

Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee Jun 2009

Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.

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Discovery Of Dual Function Acridones As A New Antimalarial Chemotype, Jane X. Kelly, Martin J. Smilkstein, Reto Brun, Sergio Wittlin, Roland A. Cooper, Kristin D. Lane, Aaron Janowsky, Robert A. Johnson, Rozalia A. Dodean, Rolf Winter, David J. Hinrichs, Michael K. Riscoe May 2009

Discovery Of Dual Function Acridones As A New Antimalarial Chemotype, Jane X. Kelly, Martin J. Smilkstein, Reto Brun, Sergio Wittlin, Roland A. Cooper, Kristin D. Lane, Aaron Janowsky, Robert A. Johnson, Rozalia A. Dodean, Rolf Winter, David J. Hinrichs, Michael K. Riscoe

Roland A. Cooper

Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both are undesirable in effective long-term strategies against multi-drug-resistant malaria. Haem remains an immutable and vulnerable target, because it is not parasite-encoded and its detoxification during haemoglobin degradation, critical to parasite survival, can be subverted by drug-haem interaction as in the case of quinolines and many other drugs. Here we describe a new antimalarial chemotype that combines the haem-targeting character of acridones, together with a chemosensitizing component that counteracts resistance to quinoline antimalarial …

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Interregional Comparison Of Karst Disturbance: West-Central Florida And Southeast Italy, Leslie North Mar 2009

Interregional Comparison Of Karst Disturbance: West-Central Florida And Southeast Italy, Leslie North

Leslie North

The karst disturbance index (KDI) consists of 31 environmental indicators contained within the five broad categories: geomorphology, hydrology, atmosphere, biota, and cultural. The purpose of this research is to apply the KDI to two distinct karst areas, west Florida, USA, and Apulia, Italy. Through its application, the utility of the index can be validated and other important comparisons can be made, such as differences in the karst legislations implemented in each region and the effect of time exposure to human occupation to each karst terrain. Humans have intensively impacted the karst of southeast Italy for thousands of years compared to …

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Skeletal Advance And Arrest In Giant Non-Metamorphosing African Clawed Frog Tadpoles (Xenopus Laevis: Daudin), Ryan Kerney, Richard Wassersug, Brian Hall Dec 2008

Skeletal Advance And Arrest In Giant Non-Metamorphosing African Clawed Frog Tadpoles (Xenopus Laevis: Daudin), Ryan Kerney, Richard Wassersug, Brian Hall

Ryan Kerney

This study examines the skeletons of giant non-metamorphosing (GNM) Xenopus laevis tadpoles, which arrest their development indefinitely before metamorphosis, and grow to excessively large sizes in the absence of detectable thyroid glands. Cartilage growth is isometric; however, chondrocyte size is smaller in GNM tadpoles than in controls. Most cartilages stain weakly with alcian blue, and several cartilages are calcified (unlike con- trols). However, cartilages subjacent to periosteum-derived bone retain strong affinities for alcian blue, indicat- ing a role for periosteum-derived bone in the retention of glycosaminoglycans during protracted larval growth. Bone formation in the head, limb, and axial skeletons is …

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