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Articles 1 - 16 of 16
Full-Text Articles in Life Sciences
Novel Ubiquitin Neuropathology In Frontotemporal Dementia With Valosin-Containing Protein Gene Mutations, Mark Forman, Ian Mackenzie, Nigel Cairns, Eric Swanson, Philip Boyer, David Drachman, Bharati Jhaveri, Jason Karlawish, Alan Pestronk, Thomas Smith, Pang-Hsien Tu, Giles Watts, William Markesbery, Charles Smith, Virginia Kimonis
Novel Ubiquitin Neuropathology In Frontotemporal Dementia With Valosin-Containing Protein Gene Mutations, Mark Forman, Ian Mackenzie, Nigel Cairns, Eric Swanson, Philip Boyer, David Drachman, Bharati Jhaveri, Jason Karlawish, Alan Pestronk, Thomas Smith, Pang-Hsien Tu, Giles Watts, William Markesbery, Charles Smith, Virginia Kimonis
Jason Karlawish
Frontotemporal dementia (FTD) with inclusion body myopathy and Paget disease of bone (IBMPFD) is a rare, autosomal-dominant disorder caused by mutations in the valosin-containing protein (VCP) gene, a member of the AAA-ATPase gene superfamily. The neuropathology associated with sporadic FTD is heterogeneous and includes tauopathies and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). However, there is limited information on the neuropathology in IBMPFD. We performed a detailed, systematic analysis of the neuropathologic changes in 8 patients with VCP mutations. A novel pattern of ubiquitin pathology was identified in IBMPFD that was distinct from sporadic and familial FTLD-U without VCP gene …
Repetition Failure Is Not Required For Maximal Strength Adaptation, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor
Repetition Failure Is Not Required For Maximal Strength Adaptation, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor
Darryl J McAndrew
No abstract provided.
Inline Control Period: An Important Methodological Design Consideration For Assessing Adaptation To A Resistance Training Intervention, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton
Inline Control Period: An Important Methodological Design Consideration For Assessing Adaptation To A Resistance Training Intervention, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton
Darryl J McAndrew
No abstract provided.
Endurance Training History Influences Individual Responsiveness To Resistance Training, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor
Endurance Training History Influences Individual Responsiveness To Resistance Training, John Sampson, Herbert Groeller, Darryl Mcandrew, Alison Britton, Nigel Taylor
Darryl J McAndrew
No abstract provided.
Mechanomyographic Measures Of Muscle Contractile Properties Are Influenced By The Duration Of The Stimulatory Pulse, Darryl Mcandrew, John Brown, Nicholas Rosser
Mechanomyographic Measures Of Muscle Contractile Properties Are Influenced By The Duration Of The Stimulatory Pulse, Darryl Mcandrew, John Brown, Nicholas Rosser
Darryl J McAndrew
No abstract provided.
Mechanomyography; Lasers For Non-Invasive Quantification Of Muscle Recovery From Exercise Induced Fatigue, Nicholas Rosser, Darryl Mcandrew, Donald Iverson
Mechanomyography; Lasers For Non-Invasive Quantification Of Muscle Recovery From Exercise Induced Fatigue, Nicholas Rosser, Darryl Mcandrew, Donald Iverson
Darryl J McAndrew
Muscle fatigue is a common clinical sign and possible precursor to musculoskeletal injury. Existing methods of detecting muscle fatigue qualify changes within muscle or across joints, but are expensive, invasive or difficult to use. A technique of mechanomyography utilising maximal percutaneous stimulation (known as the Muscle Displacement Laser {MDL}) is an easy non-invasive assessment tool, which may have considerable application in measuring muscle fatigue and determining recovery. Specifically, this study attempted to validate the MDL as a tool to measure muscle fatigue and determine the time-course of recovery from Delayed Onset of Muscle Soreness in human biceps brachii muscle. Methods: …
Muscles Within Muscles: Coordination Of 19 Muscle Segments Within Three Shoulder Muscles During Isometric Motor Tasks, Darryl Mcandrew, Xu-Feng Huang, James Wickham, Mark Brown
Muscles Within Muscles: Coordination Of 19 Muscle Segments Within Three Shoulder Muscles During Isometric Motor Tasks, Darryl Mcandrew, Xu-Feng Huang, James Wickham, Mark Brown
Darryl J McAndrew
No abstract provided.
The Effect Of Elbow Flexion Speed And Partial Limb Occlusion On Emg Activity, John Sampson, Herbert Groeller, Darryl Mcandrew, R Achttien, J Stege
The Effect Of Elbow Flexion Speed And Partial Limb Occlusion On Emg Activity, John Sampson, Herbert Groeller, Darryl Mcandrew, R Achttien, J Stege
Darryl J McAndrew
This investigation aimed to determine the neuromuscular response of the bicep brachii during heavy (6RM) dynamic resistance exercise performed to volitional exhaustion. Electromyographic (EMG) activity was compared in twelve male subjects performing dominant-limb elbow flexion exercise during four conditions: i) Explosive concentric and eccentric (SSC); ii) Explosive concentric, control eccentric (EC); iii) control (C); and iv) control with limb occlusion (CO) (110mmHg). CO and SSC are reported to increase motor unit activity when compared to control exercise (2 second flexion, 2 second extension). It was hypothesised that EMG activity will be higher in conditions of explosive exercise. Surface EMG activity …
Emg Activity And Total Work Reduction In Occluded And Non-Occluded Resistance Exercise Conditions, John Sampson, Herbert Groeller, Darryl Mcandrew, Heath Kilah
Emg Activity And Total Work Reduction In Occluded And Non-Occluded Resistance Exercise Conditions, John Sampson, Herbert Groeller, Darryl Mcandrew, Heath Kilah
Darryl J McAndrew
No abstract provided.
Muscles Within Muscles: A Mechanomyographic Analysis Of Muscle Segment Contractile Properties Within Human Gluteus Maximus, Darryl Mcandrew, John Brown, Mark Gorelick
Muscles Within Muscles: A Mechanomyographic Analysis Of Muscle Segment Contractile Properties Within Human Gluteus Maximus, Darryl Mcandrew, John Brown, Mark Gorelick
Darryl J McAndrew
No abstract provided.
Mechanomyographic Changes To The Biceps Brachii Following High Intensity Resistance Training, Herbert Groeller, John Sampson, Darryl Mcandrew
Mechanomyographic Changes To The Biceps Brachii Following High Intensity Resistance Training, Herbert Groeller, John Sampson, Darryl Mcandrew
Darryl J McAndrew
No abstract provided.
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Alan Rothman
The traditional in vitro correlate of immunological protection is the induction by a vaccine of neutralizing antibodies against the virus. It was formerly assumed that protection induced by a vaccine was solely due to neutralizing antibodies. Neutralizing antibodies are potent in the prevention of certain diseases, but virus-specific CD4+ T helper cells aid in the proliferation of specific antigen-triggered B cells to make antibodies. CD8+ T cells are responsible for eliminating virus-infected cells during viral illness, and may act as a second line of defence by becoming activated and eliminating any cells that become infected despite the presence of neutralizing …
Tea Polyphenolic Compounds On Herpes Simplex Viruses, Tin-Chun Chu, Sandra Adams, Lee Lee
Tea Polyphenolic Compounds On Herpes Simplex Viruses, Tin-Chun Chu, Sandra Adams, Lee Lee
Tin-Chun Chu, Ph.D.
No abstract provided.
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski
Michael A. Rogawski
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. We found that systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb extension (a unique behavioral characteristic of GluK1 …
Imagining Possibilities For Healthy Appalachian Communities In An Emerging Postindustrial Landscape, Brian Hoey
Imagining Possibilities For Healthy Appalachian Communities In An Emerging Postindustrial Landscape, Brian Hoey
Brian A. Hoey, Ph.D.
This paper explores how community might be re-imagined to promote incipient social and economic agendas born increasingly of broad-minded citizen initiatives within the Appalachian region aimed at what is generally understood as “development,” but of a form distinct from the prevailing models of a more industrial age. I would like to ask whether a city like Huntington, West Virginia can emerge as a progressive example of what we might term postindustrial, urban regeneration and perhaps what we might call community healing—specifically through grassroots movement now finding local governmental support in collective attempts to transform this place from one defined primarily …
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Sharone Green
The traditional in vitro correlate of immunological protection is the induction by a vaccine of neutralizing antibodies against the virus. It was formerly assumed that protection induced by a vaccine was solely due to neutralizing antibodies. Neutralizing antibodies are potent in the prevention of certain diseases, but virus-specific CD4+ T helper cells aid in the proliferation of specific antigen-triggered B cells to make antibodies. CD8+ T cells are responsible for eliminating virus-infected cells during viral illness, and may act as a second line of defence by becoming activated and eliminating any cells that become infected despite the presence of neutralizing …