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Selective Induction Of Mononuclear Phagocytes To Produce Neopterin By Interferons, Gabriele Bitterlich, Gyongyi Szabo, Ernst Werner, C. Larcher, Dietmar Fuchs, Arno Hausen, Gilbert Reibnegger, T.F. Schulz, J. Troppmair, Helmut Wachter
Selective Induction Of Mononuclear Phagocytes To Produce Neopterin By Interferons, Gabriele Bitterlich, Gyongyi Szabo, Ernst Werner, C. Larcher, Dietmar Fuchs, Arno Hausen, Gilbert Reibnegger, T.F. Schulz, J. Troppmair, Helmut Wachter
Gyongyi Szabo
Interferon-gamma (IFN-gamma) has been shown to be a potent inducer of neopterin secretion by human peripheral blood monocytes/macrophages (1). In this paper, it is shown that other known stimuli of monocytes (e.g., to secrete proteases or to migrate) such as zymosan-activated human serum, lipopolysaccharide, human C3/iC3 and zymosan coated with complement were unable to trigger monocytes/macrophages to release neopterin. Monocytes/macrophages could be stimulated solely by IFN-gamma (25 U/ml) and IFN-alpha at very high concentrations (10,000 U/ml). In the case of human peripheral blood mononuclear cells (PBMNC), basically the same pattern was observed. If however, in the buffer controls PBMNC showed …