Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Landscape Limnology: Nutrient Fluxes & Biotic Stability In Complex Mountain Watersheds, Wayne A. Wurtsbaugh, Michelle Kang, Dave M. Epstein
Landscape Limnology: Nutrient Fluxes & Biotic Stability In Complex Mountain Watersheds, Wayne A. Wurtsbaugh, Michelle Kang, Dave M. Epstein
Watershed Sciences Faculty Publications
No abstract provided.
Synthesis Of Kurasoin B Analogs, J. R. Nielson, Michael A. Christiansen, M. B. Andrus
Synthesis Of Kurasoin B Analogs, J. R. Nielson, Michael A. Christiansen, M. B. Andrus
Chemistry and Biochemistry Faculty Presentations
Kurasoin B (1), isolated in 1996 by Uchida et al, selectively inhibits Farnesyltransferase (FTase), an enzyme responsible for activating human RAS proteins (ref. 1). When RAS proteins are mutated and then activated, they contribute 20 to 30 percent of all human tumors, including those of the pancreas, colon, small intestine, lung, prostate, liver, skin, and thyroid, as well as multiple myeloma and a number of leukemias (ref. 2). Kurasoin B, therefore, has great potential as a cancer drug lead.
Phase-Transfer Catalyzed Synthesis Of The Soy Isoflavanoid S-Equol, A. W. Butler, A. L. Calvert, Michael A. Christiansen, M. B. Andrus
Phase-Transfer Catalyzed Synthesis Of The Soy Isoflavanoid S-Equol, A. W. Butler, A. L. Calvert, Michael A. Christiansen, M. B. Andrus
Chemistry and Biochemistry Faculty Presentations
S-Equol is an isoflavanoid metabolized from the isoflavone daidzein by intestinal bacteria. Only 30-50 percent of all individuals possess bacteria that produce S-Equol. Recent data supports the compound’s pharmaceutical potential for treating prostate cancer and post-menopausal estrogen deficiency (ref. 1). Because the compound is only minutely available from natural sources, an affordable asymmetric total synthesis would be necessary to generate sufficient quantities for expanded research. Only one asymmetric total synthesis of S-Equol has been reported to date, using a chiral auxiliary to give product in a 10 percent yield over 6 steps (ref. 2). It is our goal to develop …
Synthesis Of 12-Hete Using Asymmetric Phase-Transfer Catalysis, Michael A. Christiansen, M. B. Andrus
Synthesis Of 12-Hete Using Asymmetric Phase-Transfer Catalysis, Michael A. Christiansen, M. B. Andrus
Chemistry and Biochemistry Faculty Presentations
A new method of asymmetric phase-transfer-catalyzed alkylation is described. The synthetic utility of this method is demonstrated with the total syntheses of kurasoin A, kurasoin B, and S-naproxenTM, with current work toward S-equol. This methodology is currently being applied to an improved asymmetric total synthesis of the natural compound 12-S-HETE.
Phase-Transfer Catalyzed Asymmetric Synthesis Of S-Naproxen, M. A. Binkley, Michael A. Christiansen, K. H. Harper, M. B. Andrus
Phase-Transfer Catalyzed Asymmetric Synthesis Of S-Naproxen, M. A. Binkley, Michael A. Christiansen, K. H. Harper, M. B. Andrus
Chemistry and Biochemistry Faculty Presentations
This presentation explores a modified approach to Kurasoin B.
Extreme Eutrophication And Cyanotoxin Levels In Farmington Bay, A Polluted Embayment Of The Great Salt Lake, Utah, Wayne A. Wurtsbaugh, Amy M. Marcarelli, Gregory Boyer
Extreme Eutrophication And Cyanotoxin Levels In Farmington Bay, A Polluted Embayment Of The Great Salt Lake, Utah, Wayne A. Wurtsbaugh, Amy M. Marcarelli, Gregory Boyer
Watershed Sciences Faculty Publications
The Great Salt Lake of Utah is surrounded on its eastern and southern shores by 1.4 million people, with projections of 5 million by 2050. Agricultural, industrial and particularly secondary-treated domestic wastes from this population flow primarily into Farmington Bay, a 280 km2 shallow "estuary" with a mean depth near 0.5 m. Fish are rare but bird use is extensive and massive mortalities of waterfowl and shorebirds have occurred in the bay. Phosphorus loading rates of >2 g m-2yr-1 cause hypereutrophic conditions: Secchi depths are usually 0.6 mg/L, mean Chl. a is 179 ug/L and the combined trophic state index …