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Full-Text Articles in Life Sciences
Project Manager: Antibody Discovery At Distributed Bio, Pedro I. Justiniano
Project Manager: Antibody Discovery At Distributed Bio, Pedro I. Justiniano
Creative Activity and Research Day - CARD
Antibody discovery platforms have opened a new frontier in therapeutic development. Distributed Bio has built antibody libraries that produce computationally optimized antibodies pre-engineered with therapeutically desirable traits such as humanness, high CDRH3 diversity, thermostability, and other molecular scaffolding proven to pass clinical trial requirements. One of their most popular libraries is the Super Human 2.0 library. This library analyzes billions of antibodies to find the most suited antibody to bind to a specific antigen target. / As a Project Manager intern at Distributed Bio, I have been helping to manage projects of different companies to provide them with a product …
Urban Biogeography Of Fungal Endophytes In Metrosideros Excelsa Across San Francisco, Emma Gibson
Urban Biogeography Of Fungal Endophytes In Metrosideros Excelsa Across San Francisco, Emma Gibson
Creative Activity and Research Day - CARD
Trees in cities confer health and psychological benefits to the city's inhabitants, so the urban forest is a major component of human health in urban settings. Previous studies have shown that environmental factors can impact endophytic (within-plant) microbial communities of forest trees, but the effects that urban environmental factors may have on these communities are not well understood. Here, we characterized asymptomatic fungal communities in 30 individual Metrosideros excelsa trees from 6 distinct sites using culturing and molecular methods. We found high community diversity both within and among sites, and several patterns within these communities. For example, we found similarities …
Improving Habitat Restoration For Native Pollinators In San Francisco, Tyrha Delger
Improving Habitat Restoration For Native Pollinators In San Francisco, Tyrha Delger
Creative Activity and Research Day - CARD
By looking at how these three species are conserved inside and outside of San Francisco, how an urban environment might affect habitat conservation, and lessons learned from other cities’ restoration projects, we can improve urban habitat conservation projects.
Plant Biodiversity In The Face Of Climate Change: What Will Become Of Coastal Endemic Species?, Nila Le
Plant Biodiversity In The Face Of Climate Change: What Will Become Of Coastal Endemic Species?, Nila Le
Creative Activity and Research Day - CARD
How will longitudinally constrained coastal flora fare in the face of rapid anthropogenic climate change and disturbance? Coastal communities pose a unique problem for climate change and its associated risks. Species that are concentrated along the coast are naturally vulnerable to the influence of harsh abiotic ecology, such as coastal erosion and high salt concentrations. In addition, analogous to montane species-habitat interactions, coastal communities may be “pushed” off the coast edge as a result of tracking preferred climate in the face of climate variability and sea level rise. This can be problematic for species that cannot disperse quickly enough to …
The Us27 Protein Of Human Cytomegalovirus Enhances Signaling By Human Chemokine Receptor Cxcr4, Kathleen Arnolds, Juliet V. Spencer
The Us27 Protein Of Human Cytomegalovirus Enhances Signaling By Human Chemokine Receptor Cxcr4, Kathleen Arnolds, Juliet V. Spencer
Creative Activity and Research Day - CARD
Human cytomegalovirus (HCMV) is a prevalent pathogen that causes little disease except in immune-compromised hosts. HCMV establishes life-long latency by manipulating host immune responses. We have found that the US27 protein profoundly alters the activity of host chemokine receptor CXCR4. Cells expressing US27 and CXCR4 exhibited greater migration and calcium signaling than cells expressing CXCR4 alone. The mechanism for this enhanced signaling appears to be increased expression of CXCR4, and we are continuing to investigate how US27 causes up-regulation of CXCR4. This work is expected to clarify the role of US27 in immune evasion and provide insights into treatment strategies.