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Association Of Vasp Polymorphisms And Infectious Disease Burden In Global Populations And Identification Of Candidate Resistance Haplotypes In Sub-Saharan Africa, Melinda Phun, Blake Rosenn, Danny Glenn, Dhanushi Rupasinghe, James Church, David Zuzga, Shaohua Fan, Sarah Tishkoff
Association Of Vasp Polymorphisms And Infectious Disease Burden In Global Populations And Identification Of Candidate Resistance Haplotypes In Sub-Saharan Africa, Melinda Phun, Blake Rosenn, Danny Glenn, Dhanushi Rupasinghe, James Church, David Zuzga, Shaohua Fan, Sarah Tishkoff
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Enteric pathogens employ numerous strategies to breach the intestinal epithelial barrier. One critical target of these pathogens is the host cell cytoskeleton. Pathogens may induce cytoskeletal remodeling to disrupt tight junctions and increase the permeability of the epithelium to gain access to underlying tissue. Alternatively, the cytoskeletal machinery may be directly co-opted to facilitate the attachment, invasion, or intracellular motility of these pathogens. The vasodilator-stimulated phosphoprotein (VASP) is a processive actin polymerase that induces membrane remodeling through the polymerization of actin cytoskeletal filaments. Interestingly, VASP is regulated by a variety of pathogens to induce cytoskeletal remodeling in host cells. If …