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Full-Text Articles in Life Sciences
External Validity: We Need To Do More, Russell Glasgow, Lawrence Green, Lisa Klesges, David Abrams, Edwin Fisher, Michael Goldstein, Laura Hayman, Judith Ockene, C. Orleans
External Validity: We Need To Do More, Russell Glasgow, Lawrence Green, Lisa Klesges, David Abrams, Edwin Fisher, Michael Goldstein, Laura Hayman, Judith Ockene, C. Orleans
Laura L. Hayman
The article discusses the implications of two health research trends for improving the design, review and reporting of research and evaluation studies in the U.S. The first trend is the gap between research findings and application in practice. The other trend is the increased emphasis on the methodological quality of health research reports.
Increased Toll-Like Receptor (Tlr) Mrna Expression In Monocytes Is A Feature Of Metabolic Syndrome In Adolescents, Olga Hardy, Albert Kim, Carol Ciccarelli, Laura Hayman, Jean Wiecha
Increased Toll-Like Receptor (Tlr) Mrna Expression In Monocytes Is A Feature Of Metabolic Syndrome In Adolescents, Olga Hardy, Albert Kim, Carol Ciccarelli, Laura Hayman, Jean Wiecha
Laura L. Hayman
BACKGROUND: Metabolic syndrome (MetSyn) is diagnosed frequently in some but not all overweight adolescents. Chronic inflammation, as seen in obesity, is strongly associated with MetSyn. OBJECTIVES: The aim of this pilot study was to assess the correlation between activation of the innate immune system and MetSyn, independent of body mass index (BMI), in a young population. METHODS: We quantitatively measured both systemic pro-inflammatory cytokines and gene expression of Toll-like receptors (TLRs) and downstream cytokines in circulating monocytes obtained from nine adolescents with metabolic syndrome (Overwt-MetSyn) and eight BMI-matched controls (Overwt-Healthy). RESULTS: The Overwt-MetSyn group demonstrated a significant elevation in expression …