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Regardless Of Genotype, Offspring Of Vip-Deficient Female Mice Exhibit Developmental Delays And Deficits In Social Behavior., Hewlet Mcfarlane
Regardless Of Genotype, Offspring Of Vip-Deficient Female Mice Exhibit Developmental Delays And Deficits In Social Behavior., Hewlet Mcfarlane
Hewlet McFarlane
Pharmacological studies indicate that vasoactive intestinal peptide (VIP) may be necessary for normal embryonic development in the mouse. For example, VIP antagonist treatment before embryonic day 11 resulted in developmental delays, growth restriction, modified adult brain chemistry and reduced social behavior. Here, developmental milestones, growth, and social behaviors of neonates of VIP-deficient mothers (VIP +/-) mated to VIP +/- males were compared with the offspring of wild type mothers (VIP +/+) mated to VIP +/+ and +/- males, to assess the contributions of both maternal and offspring VIP genotype. Regardless of their own genotype, all offsprings of VIP-deficient mothers exhibited …
Reduced Ultrasonic Vocalizations In Vasopressin 1b Knockout Mice., Hewlet Mcfarlane
Reduced Ultrasonic Vocalizations In Vasopressin 1b Knockout Mice., Hewlet Mcfarlane
Hewlet McFarlane
The neuropeptides oxytocin and vasopressin have been implicated in rodent social and affiliative behaviors, including social bonding, parental care, social recognition, social memory, vocalizations, territoriality, and aggression, as well as components of human social behaviors and the etiology of autism. Previous investigations of mice with various manipulations of the oxytocin and vasopressin systems reported unusual levels of ultrasonic vocalizations in social settings. We employed a vasopressin 1b receptor (Avpr1b) knockout mouse to evaluate the role of the vasopressin 1b receptor subtype in the emission of ultrasonic vocalizations in adult and infant mice. Avpr1b null mutant female mice emitted fewer ultrasonic …