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Rapid Decline In Acetylcholine Release And Content Of Rat Extensor Digitorum Longus Muscle After Denervation, Diana Linden, Michael Newton, Alan Grinnell, Donald Jenden
Rapid Decline In Acetylcholine Release And Content Of Rat Extensor Digitorum Longus Muscle After Denervation, Diana Linden, Michael Newton, Alan Grinnell, Donald Jenden
Diana Linden
The amount of acetylcholine (ACh) and choline (Ch) in normal and denervated rat extensor digitorum longus (EDL) muscles, as well as that released spontaneously from these muscles, was determined by an extremely sensitive gas chromatographicmass spectrometric assay method. We found decreases in ACh content and spontaneous, resting ACh release as early as 8 h after denervation. The ACh content decreased to a plateau of 30% of control by 11 h; ACh release attained a plateau of 50% of control several hours later. These results showed that in denervated EDL muscles ACh content and spontaneous release (measured biochemically) decreased before nerve-evoked …