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Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang
Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang
Victor R. Ambros
Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits lin-41 expression in older neurons through the lin-41 3' untranslated region, lin-41 inhibits let-7 expression in younger neurons through Argonaute ALG-1. This reciprocal inhibition ensures that axon regeneration is inhibited only in older neurons. These findings show that a let-7-lin-41 regulatory circuit, which was previously …
A Forebrain Visual Projection In The Frog (Rana Pipiens), Edward Gruberg, Victor Ambros
A Forebrain Visual Projection In The Frog (Rana Pipiens), Edward Gruberg, Victor Ambros
Victor R. Ambros
In the frog (Rana pipiens) using a modification of the Fink-Heimer degeneration stain, a projection was traced from the lateral anterior thalamus via the lateral forebrain bundle to the ipsilateral striatum in the ventrolateral area of the forebrain. Striatal degeneration extended from the anterior commissure to the olfactory bulb. Single-unit microelectrode recording revealed that this area contained visual units that responded to the on and off of light.