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The Effect Of Chromosomal Position On Dosage Compensation And Ontogenic Expression Of The V+ Gene In D. Melanogaster, Jack E. Tobler

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Two manifestations of gene regulation-- dosage compensation and ontogenic regulation--were examined in normally positioned and relocated v⁺ genotypes in Drosophila melanogaster to determine the role of gene position in these control functions. Enzyme assays, used as criteria of gene activity, were performed on various genotypes containing different doses of v⁺ in normal and relocated positions in male and female flies. The results indicate that although differently positioned v⁺ genes may specify different tryptophan pyrrolase activities, they still show dosage compensation. In each case, the enzyme activity associated with each gene, either on the X, Y, or third …