Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Gtpase-Activating Protein-Binding Protein 1 Plays An Antiviral Role In Porcine Epidemic Diarrhea Virus (Pedv) Replication, Kabita Pandey
Gtpase-Activating Protein-Binding Protein 1 Plays An Antiviral Role In Porcine Epidemic Diarrhea Virus (Pedv) Replication, Kabita Pandey
Electronic Theses and Dissertations
Porcine Epidemic Diarrhea Virus (PEDV) is a non-segmented virus which uses one-stranded, positive-sense RNA as genetic material. PEDV falls under Coronaviridae family and extensive diarrhea and dehydration in nursing piglets are the major clinical signs. This emerging disease leads to huge economic loss in the pig farming. Very less studies are done towards the role of innate immunity in PEDV infection. The formation of Stress granules (SGs) are seen when cells are introduced to different stressful conditions, which also includes viral infections. SGs are formed when one of the four kinases: doublestranded RNA (dsRNA)-dependent protein kinase (PKR), PKR-like endoplasmic reticulum …
Development And Characterization Of A Recombinant Orf Virus Vector Expressing The Spike Protein Of Porcine Epidemic Diarrhea Virus, Kyle Hain
Electronic Theses and Dissertations
Orf virus (ORFV), the type member of the genus Parapoxvirus of the family Poxviridae, causes orf or cutaneous pustular dermatitis in sheep and goats. ORFV is a ubiquitous virus capable of re-infecting its hosts multiple times over time. ORFV causes a non-systemic, self-limiting disease which is usually restricted to the skin surrounding the virus entry sites. ORFV has evolved several immunomodulatory proteins (IMPs) that evade and/or modulate host immune responses to infection and contribute to virus virulence and disease pathogenesis. Given biological properties and unique immunomodula tor y properties, ORFV has gained significant attention in recent years for its …