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Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Expression Of G-Protein Inwardly Rectifying Potassium Channels (Girks) In Lung Cancer Cell Lines, Howard Plummer 3rd, Madhu Dhar, Maria Cekanova Ms, Rndr, Phd, Hildegard Schuller
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
BACKGROUND: Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and if a similar link exists in lung cancer. METHODS: GIRK1-4 expression and levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR. GIRK protein levels were determined by western blots and cell proliferation was determined by a 5-bromo-2'-deoxyuridine (BrdU) assay. RESULTS: GIRK1 mRNA was expressed in three of six small …
Volume 3, Number 2 (2005), Ut Institute Of Agriculture
Volume 3, Number 2 (2005), Ut Institute Of Agriculture
Tennessee Land, Life and Science Magazine
Issue Highlights:
- Crops that Boost Health
- Army Service
- UT's Bluegrass Club
- UT Institute of Agriculture's Economic Impact
Volume 3, Number 1 (2005), Ut Institute Of Agriculture
Volume 3, Number 1 (2005), Ut Institute Of Agriculture
Tennessee Land, Life and Science Magazine
Issue Highlights:
- Healing Waters
- Partnerships that Build Community
- Skills for Adult Success
- UT Institute of Agriculture Outreach