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The Effects Of Retinoic Acids On The Angiogenic Growth Factors Produced By Solid Tumors, Lynn C. Burgess
The Effects Of Retinoic Acids On The Angiogenic Growth Factors Produced By Solid Tumors, Lynn C. Burgess
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
These studies investigated the effects of retinoic acid (RA) on angiogenesis. Three human, neoplastic cell lines were used to examine angiogenic promotion and/or inhibition. The cell lines, U-373MG glioblastoma, DU-145 prostate carcinoma, and TCCSUP bladder transitional cell carcinoma, were treated with the following: all-trans, 9-cis, or 13-cis RA, at doses from 0.0001 to 100 μM. Hypoxia was used to assist the expression of the angiogenic phenotype. Conditioned media (CM) were prepared by growing the tumor cells in the presence of RA and hypoxia for 24 hours, and then the CM was transferred to bovine, capillary endothelial …