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Algorithms For Reconstruction Of Gene Regulatory Networks From High -Throughput Gene Expression Data, Wenping Deng
Algorithms For Reconstruction Of Gene Regulatory Networks From High -Throughput Gene Expression Data, Wenping Deng
Dissertations, Master's Theses and Master's Reports
Understanding gene interactions in complex living systems is one of the central tasks in system biology. With the availability of microarray and RNA-Seq technologies, a multitude of gene expression datasets has been generated towards novel biological knowledge discovery through statistical analysis and reconstruction of gene regulatory networks (GRN). Reconstruction of GRNs can reveal the interrelationships among genes and identify the hierarchies of genes and hubs in networks. The new algorithms I developed in this dissertation are specifically focused on the reconstruction of GRNs with increased accuracy from microarray and RNA-Seq high-throughput gene expression data sets.
The first algorithm (Chapter 2) …