Open Access. Powered by Scholars. Published by Universities.®
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Generalized Benjamini-Hochberg Procedures Using Spacings, Debashis Ghosh
Generalized Benjamini-Hochberg Procedures Using Spacings, Debashis Ghosh
Debashis Ghosh
For the problem of multiple testing, the Benjamini-Hochberg (B-H) procedure has become a very popular method in applications. We show how the B-H procedure can be interpreted as a test based on the spacings corresponding to the p-value distributions. Using this equivalence, we develop a class of generalized B-H procedures that maintain control of the false discovery rate in finite-samples. We also consider the effect of correlation on the procedure; simulation studies are used to illustrate the methodology.
Class Discovery And Prediction Of Tumor With Microarray Data, Bo Liu
Class Discovery And Prediction Of Tumor With Microarray Data, Bo Liu
All Graduate Theses, Dissertations, and Other Capstone Projects
Current microarray technology is able take a single tissue sample to construct an Affymetrix oglionucleotide array containing (estimated) expression levels of thousands of different genes for that tissue. The objective is to develop a more systematic approach to cancer classification based on Affymetrix oglionucleotide microarrays. For this purpose, I studied published colon cancer microarray data. Colon cancer, with 655,000 deaths worldwide per year, has become the fourth most common form of cancer in the United States and the third leading cause of cancer - related death in the Western world. This research has been focuses in two areas: class discovery, …