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Full-Text Articles in Life Sciences
Computational Modelling Of Human Transcriptional Regulation By An Information Theory-Based Approach, Ruipeng Lu
Computational Modelling Of Human Transcriptional Regulation By An Information Theory-Based Approach, Ruipeng Lu
Electronic Thesis and Dissertation Repository
ChIP-seq experiments can identify the genome-wide binding site motifs of a transcription factor (TF) and determine its sequence specificity. Multiple algorithms were developed to derive TF binding site (TFBS) motifs from ChIP-seq data, including the entropy minimization-based Bipad that can derive both contiguous and bipartite motifs. Prior studies applying these algorithms to ChIP-seq data only analyzed a small number of top peaks with the highest signal strengths, biasing their resultant position weight matrices (PWMs) towards consensus-like, strong binding sites; nor did they derive bipartite motifs, disabling the accurate modelling of binding behavior of dimeric TFs.
This thesis presents a novel …
Tinnitus And Dysfunctional Interactions Between Distributed Resting State Networks, Sivayini Kandeepan
Tinnitus And Dysfunctional Interactions Between Distributed Resting State Networks, Sivayini Kandeepan
Western Research Forum
It is known that peripheral lesions in the cochlea or the auditory nerve produce dysfunctional input to central auditory structures and induce changes in the auditory system causing tinnitus. Recently, it has been proposed that the unified percept of tinnitus could be considered as an emergent property of multiple overlapping dynamic brain networks, each encoding a specific tinnitus characteristic.
The aim of our study was to investigate the neuronal activation patterns associated with specific clinical tinnitus characteristics using fMRI. We hypothesize that tinnitus clinical characteristics could be associated with specific resting-state activity and connectivity patterns and that this could be …