Life Sciences Commons^™

Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton

UNLV Theses, Dissertations, Professional Papers, and Capstones

Schizophrenia is a debilitating mental disorder that affects up to 3% of the world population. The behavioral symptoms are categorized into positive and negative symptoms, which appear during late adolescence/early adulthood. Unfortunately, the underlying cellular and molecular mechanisms of the disease are poorly understood. Several hypotheses exist to explain mechanisms contributing to these behavioral alterations. One model proposes that a reduced function of the NMDA glutamate receptor on specific GABAergic interneurons may be responsible for deficits in schizophrenia. Post-mortem investigations provide evidence of reductions in both glutamate and GABA-related proteins in patients with schizophrenia. Further, GABAergic interneurons that are activated …

Nutritional And Economic Analysis Of Small-Scale Agriculture In Imbabura, Ecuador, Jake Erickson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Intervention projects in the developing world normally aim to satisfy either the nutritional needs of a group, or advancing the economic stability, but not both. One of the many issues that may arise by narrowly focusing and creating an aid program is that although a group may be fed, they are not equipped to mitigate risks that will arise after project completion and thus continue or revert back to a malnourished state. A bridge is required to join the economic and nutritional programs to create aid interventions that are sustainable past the point of donor separation.

This paper proposes the …

Developmental Adaptation Hypothesis : Aerobic Capacity, Submaximal Arterial Saturation And Pulmonary Volumes In Peruvian Quechua Natives, Melisa Kiyamu Tsuchiya

Legacy Theses & Dissertations (2009 - 2024)

The Quechua populations have inhabited the Andes for hundreds of generations. The ability to thrive in this hostile environment, leading an active and healthy life has generated research questions about the special phenotype of Andean highlanders compared to their sea-level counterparts, such as their higher pulmonary volumes and their outstanding work capacity in spite of the challenge of oxygen transport and delivery in hypoxia. In high altitude natives, there have been two main explanations for the origins of the aforementioned traits: genetic adaptation through natural selection and developmental adaptation through the exposure to hypoxia during growth.