Life Sciences Commons^™

Endurance Exercise Training Effects On Body Fatness, Vo2max Hdl-C Subfractions, And Glucose Tolerance Are Influenced By A Plin Haplotype In Older Caucasians, Nathan T. Jenkins, Jennifer A. Mckenzie, Coleen M. Damcott, Sarah Witkowski, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

Perilipins are lipid droplet-coating proteins that regulate intracellular lipolysis in adipocytes. A haplotype of two perilipin gene (PLIN) single nucleotide polymorphisms, 13041A>G and 14995A>>T, has been previously associated with obesity risk. Furthermore, the available data indicate that this association may be modified by sex. We hypothesized that this haplotype would associate with body fatness, aerobic fitness, and a number of cardiovascular (CV) risk factor phenotypes before and after a 6-mo endurance exercise training program in sedentary older Caucasians. The major haplotype group (13041A/14995A; n = 57) had significantly lower body mass index (BMI) and body fatness compared with …