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Full-Text Articles in Life Sciences

Alternatives To Laboratory Animals: Definition And Discussion, Andrew N. Rowan Dec 2018

Alternatives To Laboratory Animals: Definition And Discussion, Andrew N. Rowan

Andrew N. Rowan, DPhil

The origins of the concept of "alternatives" to the use of animals in research may be traced back to the 1800's and the furore about using live animals in surgical and other experiments. Some of the animal protection societies in England were prepared to accept animal experimentation provided it was performed under anesthesia. Even Dr. Marshall Hall, who championed the spread of experimental medicine in 19th century England, considered it necessary to control and prevent unwarranted, inept and cruel experimentation (French, 1975). The concept of alternatives has developed in the 20th century to encompass not only the reduction (prevention) of …


Ethical Foundations For The Lethal Management Of Double-Crested Cormorants (Phalocrocorax Auritus) In The Eastern United States: An Argument Analysis, Chelsea Batavia, Michael Paul Nelson Dec 2018

Ethical Foundations For The Lethal Management Of Double-Crested Cormorants (Phalocrocorax Auritus) In The Eastern United States: An Argument Analysis, Chelsea Batavia, Michael Paul Nelson

Chelsea Batavia, PhD

Lethal management of Double-crested Cormorants (Phalocrocorax auritus) has been implemented in many areas of the United States. In this paper, the philosophical method of argument analysis is used to assess ethical premises underlying the proposition that Double-crested Cormorant populations should be culled to reduce pressures on wild fisheries in the Great Lakes region of the eastern USA. This influential argument has been used to justify the destruction of more than half a million Double-crested Cormorants and hundreds of thousands of their nests and eggs. Three versions of the argument are formulated and assessed. It is shown that each of the …


Organizational Culture Change In A Texas Hospital, Alberto Coustasse-Hencke M.D., M.B.A., M.P.H. Nov 2018

Organizational Culture Change In A Texas Hospital, Alberto Coustasse-Hencke M.D., M.B.A., M.P.H.

Alberto Coustasse, DrPH, MD, MBA, MPH

Coustasse-Hencke, Alberto, MD, MBA, MPH, Organizational Culture Change in a Texas Hospital. Doctor of Public Health (Health Behavior), June 2004, 329 pp., 11 tables, 8 illustrations, bibliography, 198 titles. The purpose of this research was to analyze a Balanced Scorecard (BSC) approach in a Texas hospital with a main focus in Patient Satisfaction (PS), and to measure organizational change and its impact on PS. This dissertation also applied a "Shared Vision" of the organization as the central process in bringing forth the knowledge shared by members of the community hospital who were both subjects and research participants. The development of …


Highest And Best Use Determinations In Agricultural Land Assessments, Matthew Elliott, Lisa Elliott, Tong Wang Nov 2018

Highest And Best Use Determinations In Agricultural Land Assessments, Matthew Elliott, Lisa Elliott, Tong Wang

Matthew Elliott

Determining highest and best of use (HBU) is necessary for supportable Ag land assessments. In this study,
we determine HBU and most probable use (MPU) of South Dakota Ag land as either cropland or grassland.
To determine HBU, we simulate net returns for cropland and grassland for every possible combination of
the productivity and legal dimensions using the APEX model and copula approach. To determine MPU,
we use random forest classification given net returns, risk, topography, and soil productivity ratings. We
discuss the impacts of using MPU, HBU, and soil ratings for determining use for Ag land property
assessments.


Are Different Actions Mediated By Distinct Systems Of Knowledge In Infancy?, Peter Vishton Oct 2018

Are Different Actions Mediated By Distinct Systems Of Knowledge In Infancy?, Peter Vishton

Peter Vishton

This chapter considers why studies of infant looking and reaching often suggest different patterns of cognitive and perceptual development. In some cases, convergent results have emerged from studies of infant looking and reaching, but differences are common. The most typical results suggest less adult-like perception and cognition in studies of reaching than in studies of looking. Several reaching studies, however, do not fit this pattern, suggesting that reaching actions may be mediated by distinct systems of knowledge and information processing. Comparisons of research on other behaviors, such as crawling and walking, also suggest that infant knowledge systems vary across actions. …


D_Luftig_Data_Management_Slides.Pdf, David Luftig Oct 2018

D_Luftig_Data_Management_Slides.Pdf, David Luftig

David Luftig

These are the slides used for 10/24/2018 workshop "Campus Conversation: On-Campus Resources for Federal Grant Seekers."


Role Competency Scale On Shared Decision-Making Nurses: Development And Psychometric Properties, Joseph D. Tariman Phd, Pamela Katz, Jessica Bishop-Royse Phd, Lisa Hartle Ms, Cns, Rn, Katharine Szubski Bsn, Rn, Toreend Enecio, Ima Garcia, Nadia Spawn Msn, Katherine Jones Masterton Oct 2018

Role Competency Scale On Shared Decision-Making Nurses: Development And Psychometric Properties, Joseph D. Tariman Phd, Pamela Katz, Jessica Bishop-Royse Phd, Lisa Hartle Ms, Cns, Rn, Katharine Szubski Bsn, Rn, Toreend Enecio, Ima Garcia, Nadia Spawn Msn, Katherine Jones Masterton

Joseph D Tariman PhD, RN, ANP-BC, FAAN

Objectives: This study aimed to develop a scale that can measure the role competency of oncology nurses during shared decision-making process. Methods: A total of 226 oncology nurses who actively provide direct care to patients from inpatient and outpatient oncology units in the Midwest and Pacific Northwest completed the online or mail survey. Exploratory factor analysis and parallel analysis showed the multidimensionality of the role competency scale on shared decision-making nurses. Results: The role competency scale on shared decision-making nurses revealed four dimensions: knowledge, attitudes, communication, and adaptability. The 22 items have excellent internal consistency with a Cronbach’s alpha of …


Biosimilars: Exploring The History, Science And Proogress, Joseph D. Tariman Phd Sep 2018

Biosimilars: Exploring The History, Science And Proogress, Joseph D. Tariman Phd

Joseph D Tariman PhD, RN, ANP-BC, FAAN

BACKGROUND: Biosimilars provide opportunities for improving healthcare access and outcomes and reducing overall healthcare costs for patients with cancer.
OBJECTIVES: The purpose of this article is to explore the history of biosimilars, regulatory pathways, and barriers to biosimilar approval. This article also aims to describe the patient and clinician barriers to biosimilars use and the progress that has been achieved since the first biosimilar approval in Europe in 2006 and in the United States in 2015.
METHODS: A literature search was conducted to retrieve articles that are highly relevant to the history of biosimilars development and regulatory pathways in the …


Correlation Between Investment In Sexual Traits And Valve Sexual Dimorphism In Cyprideis Species (Ostracoda), Maria Joao Fernandes Martins, Gene Hunt, Rowan Lockwood, John P. Swaddle, David J. Horne Sep 2018

Correlation Between Investment In Sexual Traits And Valve Sexual Dimorphism In Cyprideis Species (Ostracoda), Maria Joao Fernandes Martins, Gene Hunt, Rowan Lockwood, John P. Swaddle, David J. Horne

John Swaddle

Assessing the long-term macroevolutionary consequences of sexual selection has been hampered by the difficulty of studying this process in the fossil record. Cytheroid ostracodes offer an excellent system to explore sexual selection in the fossil record because their readily fossilized carapaces are sexually dimorphic. Specifically, males are relatively more elongate than females in this superfamily. This sexual shape difference is thought to arise so that males carapaces can accommodate their very large copulatory apparatus, which can account for up to one-third of body volume. Here we test this widely held explanation for sexual dimorphism in cytheroid ostracodes by correlating investment …


Gratitude Intervention Modulates P3 Amplitude In A Temporal Discounting Task, Andrea L. Patalano, Sydney L. Lolli, Charles A. Sanislow Aug 2018

Gratitude Intervention Modulates P3 Amplitude In A Temporal Discounting Task, Andrea L. Patalano, Sydney L. Lolli, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

Gratitude has been shown to reduce economic impatience. In particular, individuals induced to experience heightened gratitude are more willing to choose delayed larger rewards over immediate smaller rewards (i.e., they have lower discounting rates) than those in a neutral condition. Using the event-related potential (ERP) method, we investigated the relation between gratitude level and neurophysiological correlates. Of interest was motivated information processing, as indexed by the P3 component. Participants were administered a gratitude or a neutral mood induction followed by a temporal discounting task (choosing between a fixed immediate reward versus a future reward that varied across trials) while electroencephalogram …


An Ethogram For Benthic Octopods (Cephalopoda: Octopodidae), Jennifer Mather, Jean S. Alupay Jun 2018

An Ethogram For Benthic Octopods (Cephalopoda: Octopodidae), Jennifer Mather, Jean S. Alupay

Jennifer Mather, PhD

The present paper constructs a general ethogram for the actions of the flexible body as well as the skin displays of octopuses in the family Octopodidae. The actions of 6 sets of structures (mantle–funnel, arms, sucker–stalk, skin–web, head, and mouth) combine to produce behavioral units that involve positioning of parts leading to postures such as the flamboyant, movements of parts of the animal with relation to itself including head bob and grooming, and movements of the whole animal by both jetting in the water and crawling along the substrate. Muscular actions result in 4 key changes in skin display: (a) …


Cephalopod Complex Cognition, Jennifer Mather Jun 2018

Cephalopod Complex Cognition, Jennifer Mather

Jennifer Mather, PhD

Cephalopods, especially octopuses, offer a different model for the development of complex cognitive operations. They are phylogenetically distant from the mammals and birds that we normally think of as ‘intelligent’ and without the pervasive social interactions and long lives that we associate with this capacity. Additionally, they have a distributed nervous system — central brain, peripheral coordination of arm actions and a completely separate skin appearance system based on muscle-controlled chromatophores. Recent research has begun to show how these apparently separate systems are coordinated. Learning and cognition are used toward prey, in antipredator actions and in courtship. These examples show …


Mating Games Squid Play: Reproductive Behaviour And Sexual Skin Displays In Caribbean Reef Squid Sepioteuthis Sepioidea, Jennifer Mather Jun 2018

Mating Games Squid Play: Reproductive Behaviour And Sexual Skin Displays In Caribbean Reef Squid Sepioteuthis Sepioidea, Jennifer Mather

Jennifer Mather, PhD

Observation of the sexual interactions of Sepioteuthis sepioidea squid during the short reproductive stage of their lives showed a scramble competition system, with both male and female polygyny. Mature females were faithful to a specific location in the daytime, whereas males moved from group to group and formed short-term consortships with females. Males defended females from other males, particularly with an agonistic Zebra display. Male–female pairs exchanged Saddle-Stripe displays, after which males might display an on–off Flicker. There was considerable female choice. Only if a female responded to this display with a parallel Rocking action would she pair and would …


Support For The Precautionary Principle, Jennifer Mather Jun 2018

Support For The Precautionary Principle, Jennifer Mather

Jennifer Mather, PhD

The precautionary principle gives the animal the benefit of the doubt when its sentient status is not known. This is necessary for advanced invertebrates such as cephalopods because research and evidence concerning the criteria for sentience are scattered and often insufficient to give us the background for the decision.


Cephalopods Are Best Candidates For Invertebrate Consciousness, Jennifer A. Mather, Claudio Carere Jun 2018

Cephalopods Are Best Candidates For Invertebrate Consciousness, Jennifer A. Mather, Claudio Carere

Jennifer Mather, PhD

Insects might have been the first invertebrates to evolve sentience, but cephalopods were the first invertebrates to gain scientific recognition for it.


An Invertebrate Perspective On Pain, Jennifer A. Mather Jun 2018

An Invertebrate Perspective On Pain, Jennifer A. Mather

Jennifer Mather, PhD

Although Key (2016) argues that mammals feel pain and fish do not, from an invertebrate perspective, it is obvious that the pain experience is shared by animals from a number of different animal groups.


Integration Of Behavioral Health For The Treatment Of Depression In Primary Care: A Practice Improvement Project, Diane Block, Eileen Stuart-Shor, Jeanne Marston, Sarah Ludlow May 2018

Integration Of Behavioral Health For The Treatment Of Depression In Primary Care: A Practice Improvement Project, Diane Block, Eileen Stuart-Shor, Jeanne Marston, Sarah Ludlow

Diane Block

Background: Mental health is a compilation of conditions frequently managed in primary care. Approximately 8 million people in the United States are diagnosed with depression annually1. Over half of these patients are managed in primary care without intervention by behavioral health1. The recurrence of depression in patients and the volume at which this problem is being treated brings to question whether depression and mental illness should be treated with specialized care in the same collaborative manner as other health conditions.
Methods:  Methods involve close monitoring of both PHQ-2 and PHQ-9 scoring, random chart audits and both survey and interview …


Explaining China’S Wildlife Crisis: Cultural Tradition Or Politics Of Development, Peter J. Li Apr 2018

Explaining China’S Wildlife Crisis: Cultural Tradition Or Politics Of Development, Peter J. Li

Peter J. Li, PhD

This chapter is about China’s wildlife crisis. As the following sections attempt to demonstrate, abuse of and assault on wildlife in captivity and in the wild have reached an unprecedented level on the Chinese mainland in the reform era (1978–present). Shocking brutality against wildlife animals has been frequently exposed by Chinese and international media. To readers outside East Asia, they ask if the Chinese are culturally indifferent to animal suffering. Indeed, does the Chinese culture sanction cruelty to animals? Or is it the contemporary politics of economic development that is more directly responsible for the crisis?


The Shellfish Corner: Shellfish Aquaculture In The Commons, Michael A. Rice Mar 2018

The Shellfish Corner: Shellfish Aquaculture In The Commons, Michael A. Rice

Michael A Rice

The major common denominator of shellfish aquaculture in coastal or estuarine waters worldwide is that most culture operations are conducted in common or public trust waters, necessitating constant interaction in the political arena with other competing interests. As a matter of practicality, the best systems for managing aquaculture lease policy in an equitable manner are on a local enough scale to facilitate stakeholder involvement, and to allow aquaculturists to organize into professional trade organizations so that the collective interest of the industry is heard in the process.


History Of The 3rs In Toxicity Testing: From Russell And Burch To 21st Century Toxicology, Martin L. Stephens, Nina S. Mak Mar 2018

History Of The 3rs In Toxicity Testing: From Russell And Burch To 21st Century Toxicology, Martin L. Stephens, Nina S. Mak

Martin Stephens, PhD

Toxicity testing is a key part of the process of assessing the hazards, safety, or risk that chemicals and other substances pose to humans, animals, or the environment. Standardized methods for such testing, typically involving animals, began to emerge during the first half of the 20th century. In 1959, British scientists William Russell and Rex Burch proposed a framework for reducing, refining, or replacing animal use in toxicology and other forms of biomedical experimentation. This “3Rs” or “alternatives” approach emerged at a time of growing sensitivity to the use of animals in experimentation, and progress in its implementation has been …


Climate Change, Cattle, And The Challenge Of Sustainability In A Telecoupled System In Africa, Tara S. Easter, Alexander K. Killion, Neil H. Carter Mar 2018

Climate Change, Cattle, And The Challenge Of Sustainability In A Telecoupled System In Africa, Tara S. Easter, Alexander K. Killion, Neil H. Carter

Neil H. Carter

Information, energy, and materials are flowing over greater distances than in the past, changing the structure and feedbacks within and across coupled human and natural systems worldwide. The telecoupling framework was recently developed to understand the feedbacks and multidirectional flows characterizing social and environmental interactions between distant systems. We extend the application of the telecoupling framework to illustrate how flows in beef affect and are affected by social-ecological processes occurring between distant systems in Africa, and how those dynamics will likely change over the next few decades because of climate-induced shifts in a major bovine disease, trypanosomosis. The disease is …


Addressing The Challenges Of Conducting Observational Studies In Sheep Abattoirs, Elyssa Payne, Melissa Starling, Paul Mcgreevy Feb 2018

Addressing The Challenges Of Conducting Observational Studies In Sheep Abattoirs, Elyssa Payne, Melissa Starling, Paul Mcgreevy

Paul McGreevy, PhD

The competing needs of maintaining productivity within abattoirs, and maintaining high standards of animal welfare, provide fertile grounds for applied research in animal behavior. However, there are challenges involved in capturing useful behavioral data from the supply chain (from paddock to processing plant). The challenges identified in this report are based on a review of the scientific literature as well as field study observations. This article describes those challenges as they relate to collecting behavioral data on livestock-herding dogs, humans and livestock as they interact in abattoirs, and provides insights and recommendations for others embarking on animal studies in confined …


Dog Behavior Co-Varies With Height, Bodyweight And Skull Shape, Paul D. Mcgreevy, Dana Georgevsky, Johanna Carrasco, Michael Valenzuela, Deborah L. Duffy, James A. Serpell Feb 2018

Dog Behavior Co-Varies With Height, Bodyweight And Skull Shape, Paul D. Mcgreevy, Dana Georgevsky, Johanna Carrasco, Michael Valenzuela, Deborah L. Duffy, James A. Serpell

Paul McGreevy, PhD

Dogs offer unique opportunities to study correlations between morphology and behavior because skull shapes and body shape are so diverse among breeds. Several studies have shown relationships between canine cephalic index (CI: the ratio of skull width to skull length) and neural architecture. Data on the CI of adult, show-quality dogs (six males and six females) were sourced in Australia along with existing data on the breeds’ height, bodyweight and related to data on 36 behavioral traits of companion dogs (n = 8,301) of various common breeds (n = 49) collected internationally using the Canine Behavioral Assessment and Research Questionnaire …


De-Identified Interviews For The Study: Data Challenges Of Biomedical Researchers In The Age Of Omics, Rolando Garcia-Milian, Denise Hersey, Milica Vukmirovic Jan 2018

De-Identified Interviews For The Study: Data Challenges Of Biomedical Researchers In The Age Of Omics, Rolando Garcia-Milian, Denise Hersey, Milica Vukmirovic

Rolando Garcia-Milian


Background: High-throughput technologies are rapidly generating large amounts of diverse omics data. Although this offers a great opportunity, it also poses great challenges as data analysis becomes more complex. The purpose of this study was to identify the main challenges researchers face in analyzing data, and how academic libraries can support them in this endeavor.
Methods: A multimodal needs assessment analysis, combined an online survey of 860 Yale-affiliated researchers and 15 in-depth one-on-one semi-structured interviews. Interviews were recorded, transcribed, and analyzed using NVivo 10® software according to the thematic analysis approach.
Results: The survey response rate was …


African Penguins Follow The Gaze Direction Of Conspecifics, Christian Nawroth, Egle Trincas, Livio Favaro Jan 2018

African Penguins Follow The Gaze Direction Of Conspecifics, Christian Nawroth, Egle Trincas, Livio Favaro

Christian Nawroth, PhD

Gaze following is widespread among animals. However, the corresponding ultimate functions may vary substantially. Thus, it is important to study previously understudied (or less studied) species to develop a better understanding of the ecological contexts that foster certain cognitive traits. Penguins (Family Spheniscidae), despite their wide interspecies ecological variation, have previously not been considered for cross-species comparisons. Penguin behaviour and communication have been investigated over the last decades, but less is known on how groups are structured, social hierarchies are established, and coordination for hunting and predator avoidance may occur. In this article, we investigated how African penguins (Spheniscus demersus) …


A Note On Pigs’ Knowledge Of Hidden Objects, Christian Nawroth, Mirjam Ebersbach, Eberhard Von Borell Jan 2018

A Note On Pigs’ Knowledge Of Hidden Objects, Christian Nawroth, Mirjam Ebersbach, Eberhard Von Borell

Christian Nawroth, PhD

Object permanence is the notion that objects continue to exist even when they are out of observer’s sight. This ability is adaptive for free ranging animals who have to cope with a dangerous and highly changeable environment and allows them to be aware of predators sneaking in their proximity or to keep track of conspecifics or food sources, even when out of sight. Farm animals might also benefit from object permanence because the ability to follow the trajectory of hidden food or objects may lead to a higher predictability of subjects’ environment, which in turn might affect the level of …


Individual Personality Differences In Goats Predict Their Performance In Visual Learning And Non-Associative Cognitive Tasks, Christian Nawroth, Pamela M. Prentice, Alan G. Mcelligott Jan 2018

Individual Personality Differences In Goats Predict Their Performance In Visual Learning And Non-Associative Cognitive Tasks, Christian Nawroth, Pamela M. Prentice, Alan G. Mcelligott

Christian Nawroth, PhD

Variation in common personality traits, such as boldness or exploration, is often associated with risk–reward trade–offs and behavioural flexibility. To date, only a few studies have examined the effects of consistent behavioural traits on both learning and cognition. We investigated whether certain personality traits (‘exploration’ and ‘sociability’) of individuals were related to cognitive performance, learning flexibility and learning style in a social ungulate species, the goat (Capra hircus). We also investigated whether a preference for feature cues rather than impaired learning abilities can explain performance variation in a visual discrimination task. We found that personality scores were consistent …


Individual Personality Differences In Goats Predict Their Performance In Visual Learning And Non-Associative Cognitive Tasks, Christian Nawroth, Pamela M. Prentice, Alan G. Mcelligott Jan 2018

Individual Personality Differences In Goats Predict Their Performance In Visual Learning And Non-Associative Cognitive Tasks, Christian Nawroth, Pamela M. Prentice, Alan G. Mcelligott

Alan G. McElligott, PhD

Variation in common personality traits, such as boldness or exploration, is often associated with risk–reward trade–offs and behavioural flexibility. To date, only a few studies have examined the effects of consistent behavioural traits on both learning and cognition. We investigated whether certain personality traits (‘exploration’ and ‘sociability’) of individuals were related to cognitive performance, learning flexibility and learning style in a social ungulate species, the goat (Capra hircus). We also investigated whether a preference for feature cues rather than impaired learning abilities can explain performance variation in a visual discrimination task. We found that personality scores were consistent …


The Shellfish Corner: Cap And Trade Systems With Shellfish May Be Good For The Economic Bottom Line, Michael A. Rice Dec 2017

The Shellfish Corner: Cap And Trade Systems With Shellfish May Be Good For The Economic Bottom Line, Michael A. Rice

Michael A Rice

The development of a traditional form of Integrated Multi-Trophic Aquaculture (IMTA) in the Dagupan City Estuary system in the Philippines is based upon different producers each focusing on individual species rather than individual producers producing multiple species with very different market values. The long-term success of such a system requires attention to local marine spatial planning and enforcement of caps on forms of feed-based (net pen or fish cage) aquaculture systems.


Heat, Disparities, And Health Outcomes In San Diego County’S Diverse Climate Zones, Kirsten Guirguis, Rupa Basu, Wael K. Al-Delaimy, Tarik Benmarhnia, Rachel Es Clemesha, Isabel Corcos, Janin Guzman-Morales, Brittany Hailey, Ivory Small, Alexander Tardy, Devesh Vashishtha, Joshua Graff Zivin, Alexander Gershunov Dec 2017

Heat, Disparities, And Health Outcomes In San Diego County’S Diverse Climate Zones, Kirsten Guirguis, Rupa Basu, Wael K. Al-Delaimy, Tarik Benmarhnia, Rachel Es Clemesha, Isabel Corcos, Janin Guzman-Morales, Brittany Hailey, Ivory Small, Alexander Tardy, Devesh Vashishtha, Joshua Graff Zivin, Alexander Gershunov

Joshua Graff Zivin

Climate variability and change are issues of growing public health importance. Numerous studies have documented risks of extreme heat on human health in different locations around the world. Strategies to prevent heat-related morbidity and reduce disparities are possible but require improved knowledge of health outcomes during hot days at a small-scale level as important within-city variability in local weather conditions, socio-demographic composition, and access to air conditioning (AC) may exist. We analyzed hospitalization data for three unique climate regions of San Diego County alongside temperature data spanning 14 years to quantify the health impact of ambient air temperature at varying …