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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, Jonathan Balcombe
Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, Jonathan Balcombe
Experimentation Collection
Animal tests yield misleading results.
Animal Models Of Head Trauma, Ibolja Cernak
Animal Models Of Head Trauma, Ibolja Cernak
Biomedicine and Animal Models in Research Collection
Animal models of traumatic brain injury (TBI) are used to elucidate primary and secondary sequelae underlying human head injury in an effort to identify potential neuroprotective therapies for developing and adult brains. The choice of experimental model depends upon both the research goal and underlying objectives. The intrinsic ability to study injuryinduced changes in behavior, physiology, metabolism, the blood/tissue interface, the blood brain barrier, and/or inflammatory- and immune-mediated responses, makes in vivo TBI models essential for neurotrauma research. Whereas human TBI is a highly complex multifactorial disorder, animal trauma models tend to replicate only single factors involved in the pathobiology …
The Future Of Teratology Research Is In Vitro, Jarrod Bailey, Andrew Knight, Jonathan Balcombe
The Future Of Teratology Research Is In Vitro, Jarrod Bailey, Andrew Knight, Jonathan Balcombe
Experimentation Collection
Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable, if the agents themselves can be identified and avoided. Billions of dollars and manhours have been dedicated to animal-based discovery and characterisation methods over decades. We show here, via a comprehensive systematic review and analysis of this data, that these methods constitute questionable science and pose a hazard to humans. Mean positive and negative predictivities barely exceed 50%; discordance among the species used is substantial; reliable extrapolation from animal data to humans is impossible, and virtually all known human teratogens have so far been identified in spite …
127 Million Non-Human Vertebrates Used Worldwide For Scientific Purposes In 2005, Andrew Knight
127 Million Non-Human Vertebrates Used Worldwide For Scientific Purposes In 2005, Andrew Knight
Experimentation Collection
No abstract provided.
Ld50 Testing Of Botulinum Toxin For Use As A Cosmetic, Martin L. Stephens, Michael Balls
Ld50 Testing Of Botulinum Toxin For Use As A Cosmetic, Martin L. Stephens, Michael Balls
Experimentation Collection
In 2003, the Fund for the Replacement of Animals in Medical Experiments (FRAME) revealed that the potency of botulinum toxin for use as a popular wrinkle treatment is assessed by using the LD50 Test. The endpoint in this mouse-based testing is death through suffocation. In 2004, The Humane Society of the United States (HSUS) sought to work with Allergan, the US-based manufacturer of Botox® Cosmetic, and the U.S. Food and Drug Administration (FDA), on ways to refine, reduce, and replace this LD50 testing. This article summarises The HSUS’s campaign in the United States and provides an update on FRAME’s continuing …
Chimpanzees In Research: Past, Present, And Future, Kathleen Conlee, Sarah T. Boysen
Chimpanzees In Research: Past, Present, And Future, Kathleen Conlee, Sarah T. Boysen
State of the Animals 2005
Although the welfare of chimpanzees encompasses many issues, this chapter addresses their use in research, including their historical and current use in the United States, ethical and scientific concerns, public opinion, international legislation, and future directions.
Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey
Non-Human Primates In Medical Research And Drug Development: A Critical Review, Jarrod Bailey
Laboratory Experiments Collection
There is much current debate surrounding the use of non-human primates (NHPs) in medical research and drug development. This review, stimulated by calls for evidence from UK-based inquiries into NHP research, takes a critical view in order to provide some important balance against papers supporting NHP research and calling for it to be expanded. We show that there is a paucity of evidence to demonstrate the positive contribution or successful translation of NHP research to human medicine, that there is a great deal of often overlooked data showing NHP research to be irrelevant, unnecessary, even hazardous to human health and …