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Full-Text Articles in Life Sciences

Dengue: Defining Protective Versus Pathologic Immunity, Alan Rothman Aug 2014

Dengue: Defining Protective Versus Pathologic Immunity, Alan Rothman

Alan Rothman

Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.


Transgenesis In Animal Agriculture And Zoonotic Disease Resistance, Michael Greger May 2014

Transgenesis In Animal Agriculture And Zoonotic Disease Resistance, Michael Greger

Michael Greger, M.D.

In 2009, the US Food and Drug Administration (FDA) released guidelines for the commercialization of genetically engineered (GE) farm animals. Numerous applications for approval of transgenic species are currently pending. Anthropocentric concerns raised to date have tended to neglect the impact of the physiological trade-off between production efficiency and immune function. Given animal agriculture's track record of prioritizing productivity - even at the expense of animal health - the incorporation of biotechnological tools to further stress production towards biological limits may continue to undermine immunocompetence. Regulatory schemata to avert adverse public health outcomes are discussed. Given the rising incidence of …


From The Centers For Disease Control And Prevention. Prevalence Of Penicillin-Resistant Streptococcus Pneumoniae--Connecticut, 1992-1993, E. Simpson Apr 2014

From The Centers For Disease Control And Prevention. Prevalence Of Penicillin-Resistant Streptococcus Pneumoniae--Connecticut, 1992-1993, E. Simpson

E. Hatheway Simpson

To determine the extent of antimicrobial susceptibility testing of Streptococcus pneumoniae and the prevalence of penicillin resistance among pneumococcal isolates from July 1992 through June 1993, in August 1993 the Connecticut Department of Public Health and Addiction Services (DPHAS) surveyed all 44 hospitals with clinical microbiology laboratories in Connecticut. This report summarizes the results of that survey.


Factor Structure Of The Chinese Service Quality Assessment Scale, Siu-Yin Cheung, Eddie Lam, Jia-Wen Shao, Jennifer Mak Jan 2014

Factor Structure Of The Chinese Service Quality Assessment Scale, Siu-Yin Cheung, Eddie Lam, Jia-Wen Shao, Jennifer Mak

Jennifer Y Mak

The quality of service has been the major subject of interest for business and academia. The aims of this study were to investigate the service quality of fitness clubs in Hong Kong and Guangzhou and to examine the underlying factor structure of the Service Quality Assessment Scale (SQAS; Lam, Zhang, & Jensen, 2005) in the Chinese context.


Effects Of Polychlorinated Biphenyl (Pcb) On Response Perseveration And Ultrasonic Vocalization Emission In Rat During Development, Howard Cromwell Dec 2013

Effects Of Polychlorinated Biphenyl (Pcb) On Response Perseveration And Ultrasonic Vocalization Emission In Rat During Development, Howard Cromwell

Howard Casey Cromwell

The 3 major symptoms of autistic spectrum disorders include 1) social behavioral alterations, 2) problems in communication and 3) higher-order motoric deficits of perseveration and stereotyped movements. Previous work has shown that early developmental exposure to polychlorinated biphenyls (PCBs) alters rat pup social motivation and juvenile rat social recognition/investigation. The present work extends this previous research by examining how perinatal PCB exposure alters motoric functions and communication abilities at different stages of development. Action perseveration was examined using performance measures from a T-maze environment. Communication abilities were evaluated by monitoring ultrasound emission in rat pups during a brief isolation from …


Ankle Plantarflexion Strength In Rearfoot And Forefoot Runners: A Novel Clusteranalytic Approach, Dominik Liebl, Steffen Willwacher, Joseph Hamill, Gert-Peter Brüggemann Dec 2013

Ankle Plantarflexion Strength In Rearfoot And Forefoot Runners: A Novel Clusteranalytic Approach, Dominik Liebl, Steffen Willwacher, Joseph Hamill, Gert-Peter Brüggemann

Joseph Hamill

The purpose of the present study was to test for differences in ankle plantarflexion strengths of habitually rearfoot and forefoot runners. In order to approach this issue, we revisit the problem of classifying different footfall patterns in human runners. A dataset of 119 subjects running shod and barefoot (speed 3.5 m/s) was analyzed. The footfall patterns were clustered by a novel statistical approach, which is motivated by advances in the statistical literature on functional data analysis. We explain the novel statistical approach in detail and compare it to the classically used strike index of Cavanagh and Lafortune (1980). The two …