Life Sciences Commons^™

The Temporal Nature Of The Acute Stress Response And Its Impact On Explicit Learning, Steven B. Hutchinson

Electronic Theses and Dissertations

Acute stress is commonly experienced by many throughout their lives. Given the demanding lifestyle of many career paths, it's important to gauge the influence of these stressors upon cognitive performance. The present dissertation focus' upon explicit learning in attempts to explore one avenue of the stress-cognition relationship. The Trier Social Stress Test (TSST) was used as a lab stressor for Experiments 1 and 2, in which participants are asked to give a speech and complete a difficult math task in front of 2 evaluators trained to monitor non-verbal behavior. Experiment 1 investigates the dynamic stress response during the minutes following …

Training A New Trick Using No-Reward Markers: Effects On Dogs’ Performance And Stress Behaviors, Naomi Rotenberg

Theses and Dissertations

This study explored using no-reward markers (NRMs). Dogs were taught a novel trick. In the IG group dogs’ errors were ignored; in the NRM group they elicited a tone. Performance and stress were evaluated. IG dogs reached higher levels of performance, with no difference in the frequency of stress behaviors.

Exploring And Training Spatial Reasoning Via Eye Movements: Implications On Performance, Victoria A. Roach

Electronic Thesis and Dissertation Repository

This dissertation sought to determine if eye movements could serve as an indicator of success in spatial reasoning, and if eye movements associated with successful completion could be applied to strategically improve spatial reasoning.

Using the line images of Shepard and Metzler, an electronic test of mental rotations ability (EMRT) was designed. Two versions of the test were created, allowing for both a timed (6 seconds per question) and untimed testing environment. Four experiments were designed and completed to relate mental rotation ability (MRA) scores from the EMRT, to patterns in chrononumeric and visual salience data. In each experiment, participants …

The Role Of Valproic Acid, A Histone Deacetylase Inhibitor, In Reducing Anxiety Levels In Rats: An Epigenetics Study, Juliet Buteme

Honors College Theses

Rats, like humans, show personality traits: they are born with different anxiety levels (i.e., high (HAn) or low anxiety (LAn) levels). In this study, we investigated (1) if treatment with valproic acid (VPA) can lower anxiety level in trait anxiety rats and (2) how VPA may interact with environment (e.g., enriched (EE), standard (SE) and isolated environments (IE)). VPA is a deacetylase inhibitor that increases Histone 3 acetylation, a known epigenetic mechanism that interacts with stress response proteins, and treats epilepsy and mood disorders. Since rats reared in IE exhibit heightened anxiety levels as compared to those in EE, we …

Functionally Distinct Pools Of Calcineurin Contribute To Depotentiation-Like Synaptic Changes In The Lateral Amygdala During Auditory Fear Extinction, Elena Kay Rotondo

Theses and Dissertations

Until recently, auditory fear extinction was not thought to modify substrates involved in the storage of the original auditory fear memory. Evidence now suggests that extinction results in the reversal of the fear conditioning-induced potentiation of thalamic inputs to the lateral amygdala. However, little is known about the molecular mechanisms that support this depotentiation of synaptic strength. Here we present behavioral and molecular evidence in support of the contribution of two distinct pools of the protein phosphatase calcineurin to depotentiation-like changes in lateral amygdala AMPA receptor trafficking during auditory fear extinction. Calcineurin protein that exists prior to the onset of …

Same-Sex Socio-Sexual Interactions Among A Group Of Captive Bottlenose Dolphins (Tursiops Truncatus), Natalia Botero Acosta

Master's Theses

Bottlenose dolphins (Tursiops truncatus) frequently engage in non-reproductive sexual behavior, including homosexual encounters. In order to better understand the nature and function of these interactions, a longitudinal study of the patterns of association and the dynamics of initiator/recipient role exchange was conducted. Underwater video footage of a colony of bottlenose dolphins housed at the Roatan Institute for Marine Sciences (RIMS), collected between March of 2010 and May of 2013, was analyzed. Associations occurring during homosexual interactions were transitory for most individuals. Nonetheless, subsequent analyses allowed the rejection of the null hypothesis of random association, suggesting the existence of …

The Lived Experiences Of An Injured Athlete And Members Of A Performance Management Team During Injury Rehabilitation: An Interpretative Phenomenological Analysis, Courtney Wynne Hess

Theses and Dissertations

In response to an ever growing understanding of the biopsychosocial nature of health and well-being, multidisciplinary and interdisciplinary approaches to rehabilitation have grown in acceptance over the past decade. Studies that have explored the effect of these two approaches have found them to be effective in improving rehabilitation outcomes (McAlister et al., 2001; Tur et al., 2003). Although they have been shown to be objectively effective, the impact that these approaches have on the lived experiences of the team employing them, and the athlete or patient they serve, is not well understood. As such, the purpose of the current study …

Are Large Dogs Smarter Than Small Dogs? Investigating Within Species Differences In Large And Small Dogs: Spatial Memory, Megan S. Broadway

Master's Theses

The study of canine cognition can be useful in understanding the ontology and selective pressures that affect the development of cognitive abilities. Dogs have undergone intensive artificial selection yielding distinctive breeds which differ both phenotypically and behaviorally. Breed based cognitive differences have not been found but some studies suggest there may be differences in broader categories such as working disposition and sex. The influence of size on canine cognition has not been thoroughly addressed despite the fact that large dogs are often perceived to be ‘smarter’ than small dogs. This preconception has only recently been addressed and supported in one …

Behavioral And Neural Mechanisms Of Impulsive Choice, Jesse Mcclure

Doctoral Dissertations

Impulsive choice is defined as the preference for a small immediate reward over a larger delayed reward. Individual variablity in impulsive choice correlates with many socially relevant behaviors. Although forms of impulsive choice have been studied in both behavioral ecology and psychology, the exchange of knowledge between these fields is just beginning. Drawing from both of these fields will improve our research methods allowing for a more detailed understanding of this complex behavior. Existing tasks to measure impulsive choice conflate the delay and quantity of the reward. To address this, I have drawn from foraging research to establish a method …

The Role Of The Vta Nmda Receptors, Vta Da Cells And Vta Terminal Regions In Reward-Related Learning, Karen Kest

Dissertations, Theses, and Capstone Projects

Reward-related learning occurs when an initially neutral stimulus acquires the capacity to elicit responses similar to an unconditioned stimulus (US) with which it is associated, in which case the stimulus now functions as a conditioned stimulus (CS). The mechanisms whereby stimuli come to function as CSs are not fully understood and comprise the theme of this dissertation. We have previously proposed that coincident signals from an unconditioned and the eventual conditioned stimulus (US and CS) signals on dopamine (DA) cells of the ventral tegmental area (VTA) leads to strengthening of CS synapses, allowing the CS to acquire the ability to …

Effects Of Nicotine On A Translational Model Of Working Memory, David Alderson Macqueen

USF Tampa Graduate Theses and Dissertations

Cognitive research with human non-smokers has demonstrated that nicotine generally enhances performance on tasks of attention but, working memory does not appear to be affected. In contrast, nicotine has been shown to produce robust enhancements of working memory in non-human animals. To address this disparity, the present study investigated the effects of nicotine (2mg, 4mg nicotine gum, and placebo) on the performance of 30 non-smokers (15 male) completing a working memory task developed for rodents (the odor span task, OST). Nicotine has been reported to enhance OST performance in rodents and the present study sought to determine whether the effect …

Neural And Behavioural Responses To Rewards And Losses In Early Development: A Functional Magnetic Resonance Imaging Study, Niki Hosseini-Kamkar

Electronic Thesis and Dissertation Repository

Functional magnetic resonance imaging (fMRI) was used to investigate the neural and behavioural correlates of learning from rewards and losses in children. Greater blood-oxygen-level dependent (BOLD) responses in the ventral striatum (VS) and the ventromedial prefrontal cortex (VMPFC) were found when participants received rewards compared to when they missed out on an opportunity to receive rewards. In contrast, greater BOLD responses in the anterior insula (AI) and the anterior cingulate cortex (ACC) were found when participants received losses compared to when they avoided losing. The BOLD response to rewards in the VS and VMPFC correlated positively with the tendency to …

Estrogen-Sensitive Learning Is Not Affected By Combination Ethinyl Estradiol And Levonorgestrel Oral Contraceptive Use, Darlene F. Ficco

Doctoral Dissertations

Two studies were conducted to explore the cognitive effects of combination ethinyl estradiol and levonorgestrel contraceptive use during late adolescence and young adulthood. Three groups of females, naturally cycling, active pill phase, and hormone-free interval phase, were tested on a battery of estrogen-sensitive, i.e., place learning and word generation, and estrogen-insensitive, i.e., map drawing, mental rotation, digit span, story recall, and object recall, tasks. Study 2 was conducted as a means to replicate the findings observed in Study 1 and to manipulate task difficulty and sensitivity. Two measures of mood were administered, and salivary estradiol levels at time of testing …

Relationships Between Age And White Matter Integrity In Children With Phenylketonuria, Erika M. Wesonga

Arts & Sciences Electronic Theses and Dissertations

Objective: Phenylketonuria (PKU) is a hereditary metabolic disorder associated with cognitive compromise. Diffusion tensor imaging (DTI) has allowed detection of poorer microstructural white matter integrity in children with PKU, with decreased mean diffusivity (MD) in comparison with healthy children. However, very little research has been conducted to examine the trajectory of white matter development in this population. The present study investigated potential differences in the developmental trajectory of MD between children with early- and continuously-treated PKU and healthy children across a range of brain regions.

Methods: Children with PKU (n = 31, mean age = 12.2 years) were …

Relationship Between Learning-Related Synaptic And Intrinsic Plasticity Within Lateral Amygdala, Megha Sehgal

Theses and Dissertations

A central question in neuroscience is to determine the mechanisms that govern formation, storage and modulation of memories. Determining these mechanisms would allow us to facilitate new memory formation as in the case of aging-related cognitive decline or weaken preexisting pathological memories such as traumatic memories and cue-induced drug craving. Pharmacological and genetic manipulation of intrinsic neuronal excitability has been demonstrated to impact the strength of memory formation, allocation of memories, and modulation of memories through retrieval and reconsolidation-dependent processes. In addition to experimental manipulations of intrinsic excitability, intrinsic plasticity, a change in neuronal intrinsic excitability, can be brought about …

An Analysis Of The Interaction Of Methylphenidate And Nicotine In Adolescent Rats: Effects On Bdnf, Elizabeth D. Freeman

Electronic Theses and Dissertations

This investigation was an analysis of the interaction of adolescent exposure to methylphenidate (MPH; trade name: Ritalin) on nicotine sensitization and conditioned place preference (CPP) in a rodent model and underlying mechanisms of this effect. Animals were treated IP with 1 mg/kg MPH or saline using a ―school day‖ regimen of five days on, two days off, from postnatal day (P) 28-50. During the final two weeks of MPH treatment, animals were either behaviorally sensitized to nicotine (0.5 mg/kg free base) or saline for 10 days, or conditioned to nicotine or saline using the CPP behavioral paradigm. In addition, three …

The Effect Of Sleep On Perceptual Learning And Memory Consolidation, Vanessa Claire Irsik

UNLV Theses, Dissertations, Professional Papers, and Capstones

An ability to segregate speech accurately is essential given that most auditory environments contain other overlapping conversations or environmental noise. While perceiving speech among background noise can be difficult in and of itself, those with hearing impairments can experience considerable difficulty. While training has been shown to benefit perceptual segregation of trained sounds, it is unclear how such training transfers to sounds not included in a training regimen. The current study aimed to address this question by training listeners on a portion of sounds during a vowel segregation task, and subsequently testing on both the trained sounds and untrained sounds. …

Mechanisms For Social Influence, Jeremy David Auerbach

Masters Theses

Throughout the thesis, I study mathematical models that can help explain the dependency of social phenomena in animals and humans on individual traits. The first chapter investigates consensus building in human groups through communication of individual preferences for a course of action. Individuals share and modify these preferences through speaker listener interactions. Personality traits, reputations, and social networks structures effect these modifications and eventually the group will reach a consensus. If there is variation in personality traits, the time to reach consensus is delayed. Reputation models are introduced and explored, finding that those who can best estimate the average initial …

Executive Function Predictors Of Children's Talk, Jacqlyne D. Weber

Undergraduate Honors Theses

Relatively few studies have investigated the relationship between executive functioning (EF) and language development, and even fewer have researched hot and cool EF as a predictor language development. This study is an investigation into the relationship between EF and language development in preschool aged children. More specifically, the ability for hot or cool EF to predict language, this will be the focus of the study. It was found that hot EF was a better predictor of language development in preschool aged children.

A Kinematic Analysis Of Visual And Haptic Contributions To Precision Grasping In A Patient With Visual Form Agnosia And In Normally-Sighted Populations, Robert Whitwell

Electronic Thesis and Dissertation Repository

Skilled arm and hand movments designed to obtain and manipulate objects (prehension) is one of the defining features of primates. According to the two visual system hypothesis (TVSH) vision can be parsed into two systems: (1) the ventral ‘stream’ of the occipital and inferotemporal cortex which services visual perception and other cognitive functions and (2) the ‘dorsal stream’ of the occipital and posterior parietal cortex which services skilled, goal-directed actions such as prehension. A cornerstone of the TVSH is the ‘perception-action’ dissociation observed in patient DF who suffers from visual form agnosia following bilateral damage to her ventral stream. DF …

Testing Visual Ecology Hypotheses In Avian Brood Parasite-Host Systems: The Role Of Uv-Light Perception And Egg-Nest Contrast In Foreign Egg Rejection, Zachary Aidala

Dissertations, Theses, and Capstone Projects

Color signals are highly important features of animal communication systems, particularly among birds, which possess exquisitely complex visual perception systems. Birds possess tetrachromatic vision, and some species are sensitive to ultraviolet (UV) wavelengths. Because human and avian visual systems dramatically differ (i.e. humans are not sensitive to UV wavelengths), biologically relevant sensory models are necessary to accurately assess the function of avian color signals. In this dissertation, I primarily use brood parasite-host interactions as a model for studying the behavioral function of avian-perceivable visual stimuli. In Chapter 1, I review the importance of employing biologically relevant sensory-perceptual visual models when …

Are There Multiple Kinds Of Episodic Memory? An Fmri Investigation Comparing Autobiographical And Recognition Memory Tasks, Hung-Yu Chen

Arts & Sciences Electronic Theses and Dissertations

What brain regions underlie retrieval from episodic memory? The bulk of research addressing this question has relied upon laboratory-based recognition memory. Another, less dominant tradition has employed autobiographical methods, whereby people recall events from their lifetime, often after being cued with words or pictures. Previous research comparing regions underlying successful memory retrieval between these two methodological approaches has shown mixed results. To examine the neural processes underlying recognition memory for materials encountered in the laboratory and autobiographical memory, we conducted a within-subject study using fMRI. We showed participants indoor and outdoor scenes under two types of instructions: In the lab-based …

The Short And Long-Term Effects Of Chronic Ketamine During Adolescence On Object Recognition Memory In Rats, William Hardin

Seton Hall University Dissertations and Theses (ETDs)

Prior research has demonstrated that ketamine causes deficits in object recognition and location memory following both acute and chronic administration (Pitsikas & Boultadakis, 2009; Venãncio et al., 2011). Although it is well established that abuse of many different kinds of drugs during the critical developmental period of adolescence can lead to impairments in cognition later in adulthood (Gilpin et al., 2012; Wagner et al., 2010), no research has investigated the effects of chronic ketamine administration during adolescence and its effects on behavior in adulthood. With recent research establishing that chronic ketamine during adolescence produces late-onset alterations in electrophysiology during adulthood …

Mixed-Species Flock Members’ Reactions To Novel And Predator Stimuli, Sheri Ann Browning

Doctoral Dissertations

Novel stimuli are ubiquitous. Few studies have examined mixed-species group reactions to novelty, although the complex social relationships that exist can affect species’ behavior. Additionally, studies rarely consider possible changes in communication. However, for social species, changes in communication, including rates, latencies, or note-types within a call, could potentially be correlated with behavioral traits. As such, this research aimed to address whether vocal behavior is correlated with mixed-species’ reactions to novel objects. I first tested the effect of various novel stimuli on the foraging and calling behavior of Carolina chickadees, Poecile carolinensis, and tufted titmice, Baeolophus bicolor. Chickadees …

Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis

Theses and Dissertations

The consolidation of fear memories is known to depend on a number of critical cellular processes including de novo protein synthesis and 26S proteasome-dependent protein degradation following auditory fear conditioning (Jarome et al., 2011; Kwapis et al., 2011). Early work has suggested that protein degradation, mediated by the ubiquitin proteasome system (UPS), may regulate the requirement for de novo protein synthesis during memory consolidation (Jarome & Helmstetter, 2014). However, the precise way in which the UPS is able to regulate mechanisms of protein synthesis remain unclear. In the present set of experiments, we investigated the role of the protein phosphatase …

Comparing Functional Motor Control And Gait Parameters In Children With Autism To Those Of Age-Matched Peers Who Are Typically Developing, Patricia Stevenson, Samantha Novotny, Jillian May, Christopher Ancell

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to compare motor performance of children with Autism Spectrum Disorder (ASD) to that of age-matched peers who are typically developing (TD) on motor control tasks plus symmetry and variability of gait parameters across four walking conditions. A sample of convenience of children with ASD (n=6) and peers who are TD (n=6) were recruited. Motor control was assessed using initiation and completion times on the Timed Up and Go (TUG) test. Gait parameters were collected using a computerized walkway under four trial conditions: 1) walking at self-selected velocity (SSV); 2) walking during a tray-carrying task …

A Descriptive Study Of The Use Of Neurofeedback In Counseling, Khwlah Jamil Al-Ansari

Graduate Theses and Dissertations

This study examines neuro-counseling in the mental health field and the concept of neurofeedback training (NFB) as an intervention in the counseling profession. Numbers of studies have indicated that NFB may be effective in the field of counseling. The purpose of this survey study is to explore the use of neurofeedback in the field of counseling.

Additionally, the study used a quantitative descriptive survey research method and descriptive statistics. The survey was sent to members of the American Counseling Association (ACA), and 93 professionals participated. The majority of the sample was licensed professional counselors, professionals with a degree in counseling, …

Functional Capacity In Schizophrenia: Relationship Among Effort, Reinforcement Learning And Self-Beliefs, Sally J. Vogel

UNLV Theses, Dissertations, Professional Papers, and Capstones

Individuals with schizophrenia exhibit a wide range of complex neurocognitive, psychiatric and behavioral impairments. Recent research suggests that this complex array of symptoms can be at least partially accounted for by dysfunction in more basic mechanisms, such as the ability to learn from positive and negative reinforcement, or the ability to exert adequate effort when completing simple tasks. Evidence also suggests that deficits in these basic mechanisms may contribute to more complex symptoms, such as functional impairment. Also, the relationship between neurocognitive deficits and functional impairment has been found to be mediated by defeatist performance beliefs. However, studies have not …

Move, Interact, And Connect Personally Barter Theatre’S Project Real Gets Implicit In Order To Learn, Megan E. Atkinson

Electronic Theses and Dissertations

Body movement, hands-on activity, embodiment, social interaction, emotions, and self-reflection allow teaching artists of Barter’s Theatre’s Project REAL to conduct a lesson with an implicit learning experience as the focus. Barter Theatre’s Project REAL exists as a theatre for education program that collaborates with regular classroom teachers on delivering the curriculum through specific theatre exercises in order to connect the material personally to the students’ lives. Theatre tools provide a human experience that enhances learning for the student by use of kinesthetic movement, social learning, emotions and interpersonal skills. To understand the effects of Barter Theatre’s Project REAL, the director …

Inverse Changes In Ghrelin And A2a Receptor Gene Expression Levels In The Hippocampus Of Heart Failure Canines Following Spinal Cord Stimulation, Benjamin E. Jewett

Undergraduate Honors Theses

Myocardial infarction (MI), often referred to as a heart attack, is a serious health issue in the United States. There is a well-documented link between MI and major depressive disorder (MDD), with a high incidence of MDD occurring after an MI. Overlapping pathologies have been observed within the hippocampus of the brain in animal models of MI and depression. These observations suggest that pathobiological cross-talk between the heart and brain could have a role in the etiology of MDD that occurs after an MI. Spinal cord stimulation (SCS) has previously been shown to have both cardioprotective and neuroprotective effects post-MI, …