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Combination Of Curcumin And Luteolin Synergistically Inhibits Tnf-Α-Induced Vascular Inflammation In Human Vascular Cells And Mice, Lijuan Zhang, Xiaoyong Wang, Longyun Zhang, Carlos Virgous, Hongwei Si

Human Sciences Faculty Research

Emerging evidence shows that phytochemicals, the secondary plant metabolites present in a large variety of foods, have the potential ability in reducing the risk of cardiovascular diseases. However, the dosages of phytochemicals in the cellular and animal studies are too high to reach in humans by relevant foods or dietary supplement intake. The aims of this study were to investigate whether and how combined curcumin and luteolin synergistically inhibit tumor necrosis factor-alpha (TNF-α)-induced monocytes adhesion endothelium, a crucial step of the development of endothelial dysfunction, both in human vascular cells and mouse aortic endothelium. Our results show that combined curcumin …